Results 151 to 160 of about 827,746 (374)

Possible association of Firmicutes in the gut microbiota of patients with major depressive disorder

Neuropsychiatric Disease and Treatment, 2018
Background Gut microbiota can affect human behavior and mood in many ways. Several studies have shown that patients with depression were also accompanied with gut microbiota disorder, in which Firmicutes are related to the protective function of ...
Yichen Huang, Xing Shi, Zhiyong Li, Yang Shen, Xinxin Shi, Liying Wang, Gaofei Li, Ye Yuan, Jixiang Wang, Yongchao Zhang, Lei Zhao, Meng Zhang, Yu Kang, Ying Liang   +13 more
semanticscholar   +1 more source

hESCs‐derived Organoids Achieve Liver Zonation Features through LSEC Modulation

Advanced Science, EarlyView.
This article addresses the absence of zonation features in current organoid models by co‐culturing human embryonic stem cell‐derived hepatocytes with liver sinusoidal endothelial cells exhibiting distinct zonal characteristics. It demonstrates that differential WNT2 signaling from endothelial cells modulates hepatocyte zonation and metabolic functions,
Yuying Zhang, Chenyan Huang, Lei Sun, Lyu Zhou, Yudi Niu, Kaini Liang, Bingjie Wu, Peng Zhao, Zhiqiang Liu, Xiaolin Zhou, Peng Zhang, Jianchen Wu, Jie Na, Yanan Du   +13 more
wiley   +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

Cornu Ammonis Changes Are at the Core of Hippocampal Pathology in Depression

Chronic Stress, 2019
Commentary on: Roddy DW, Farrell C, Doolin K, Roman E, Tozzi L, Frodl T, O'Keane V, O'Hanlon E. The Hippocampus in Depression: More Than the Sum of Its Parts? Advanced Hippocampal Substructure Segmentation in Depression. Biol Psychiatry. 2019 Mar 15;85(6)
Darren Roddy, Veronica O’Keane
doaj   +1 more source

Treatment of Major Depressive Disorder in Pediatric Populations

Diseases, 2018
Major depressive disorder (MDD) is a severe illness that afflicts about 16.6% of people over their lifetime. MDD is highly correlated with suicidality, and often first presents in adolescence.
Drew R. Neavin, Jeremiah Joyce, Cosima Swintak   +2 more
doaj   +1 more source

Recognition and Treatment of Cognitive Dysfunction in Major Depressive Disorder

Frontiers in Psychiatry, 2018
Major Depressive Disorder (MDD) is a prevalent, chronic, disabling, and multidimensional mental disorder. Cognitive dysfunction represents a core diagnostic and symptomatic criterion of MDD, and is a principal determinant of functional non-recovery ...
Hannah Zuckerman, Z. Pan, Caroline Park, E. Brietzke, Natalie Musial, Aisha S. Shariq, M. Iacobucci, Samantha J. Yim, L. Lui, Carola Rong, R. McIntyre   +10 more
semanticscholar   +1 more source

Implantable Self‐Powered Systems for Electrical Stimulation Medical Devices

Advanced Science, EarlyView.
In this paper, the design strategy and clinical application of ISS are discussed in depth from four aspects: the design and optimization of the energy collection module, the selection and preparation of adaptive electrode materials, the innovation of system design strategy, and the biological effect of electrical stimulation of ISS.
Xi Cui, Li Wu, Chao Zhang, Zhou Li
wiley   +1 more source

Understanding the dynamics of support seeking in women with lived experience of non‐physical intimate partner violence (IPV) and the service responses—A qualitative study

Australian Journal of Social Issues, Volume 57, Issue 4, Page 861-879, December 2022., 2022
Abstract Non‐physical abuse is a form of intimate partner violence (IPV), which negatively impacts physical and mental well‐being. The study objectives were to understand the process of support seeking amongst women who experience non‐physical IPV. Interviews were conducted with women who have experience of non‐physical IPV and support workers.
Karishma Doolabh, Colleen Fisher, Melissa O'Donnell   +2 more
wiley   +1 more source

High level of pattern glare in major depressive disorder

BMC Psychiatry, 2019
Background Visual deficits have been reported in abundance by recent studies on major depressive disorder. Pattern glare manifests as visual distortions, such as the symptoms of headache, glare, eyestrain, illusions of shapes, colors, and motion when ...
Xiongwei Qi, Huanhuan Fan, Xiao Yang, Yayun Chen, Wei Deng, Wanjun Guo, Qiang Wang, Eric Chen, Tao Li, Xiaohong Ma   +9 more
doaj   +1 more source

Machine learning approaches in Detecting the Depression from Resting-state Electroencephalogram (EEG): A Review Study [PDF]

arXiv, 2019
In this paper, we aimed at reviewing several different approaches present today in the search for more accurate diagnostic and treatment management in mental healthcare. Our focus is on mood disorders, and in particular on the major depressive disorder (MDD). We are reviewing and discussing findings based on neuroimaging studies (MRI and fMRI) first to
arxiv