Results 181 to 190 of about 832,143 (393)
Advanced Science, EarlyView.The chronic glutamate‐induced excitotoxicity hypothesis has profoundly informed the therapeutic strategies employed in Alzheimer’s disease (AD). This study shows pigment epithelium‐derived factor (PEDF) regulates astrocytic glutamate transporter‐1 (GLT‐1)‐mediated glutamate homeostasis and cognition. Reduced PEDF correlates with lower Mini‐Mental State
Jin‐Hui Shi +15 more
wiley +1 more source
Excessive Daytime Sleepiness in Hypertensive Patients: The Role of Major Depressive Disorder
DiagnosticsThere is a special relationship between major depressive disorder and excessive daytime sleepiness. However, given the negative impact of excessive daytime sleepiness on life quality and cardiovascular outcome in hypertensive patients, the objective of ...
Alexandre Younes +4 more
doaj +1 more source
Advanced Science, EarlyView.This study reveals that early rather than late administration of S‐ketamine can ameliorate PTSD symptoms. This phenomenon is attributed to reversing the progressive inhibition of VTADA neurons and the function of VTADA‐OFC circuit following stress. Targeted stimulation of the OFC by TI‐NIBS to enhance DA release effectively extends the therapeutic time
Ye Wang +20 more
wiley +1 more source
The mental health of children and adolescents: report on the second Australian child and adolescent survey of mental health and wellbeing [PDF]
, 2015 FOREWORD This report provides compelling reading for everyone interested in the health and wellbeing of Australian children and adolescents. Based on a survey conducted in the homes of over 6,300 families with children and/or adolescents aged 4 to 17 ...
David Lawrence +6 more
core
A double-blind, randomized parallel-group, efficacy and safety study of intramuscular S-adenosyl-L-methionine 1,4-butanedisulphonate (SAMe) versus imipramine in patients with major depressive disorder [PDF]
, 2002 P. Pancheri +2 more
openalex +1 more source
Advanced Science, EarlyView.Circardian rhythm disorder (CRD) causes abnormal expression of intestinal Period 2 (Per2) gene, which compromising intestinal barrier integrity and altering the gut microenvironment. Microbiota dysbiosis and aberrant metabolites production drive central inflammation, impair neurogenesis, and promote functional deficits, ultimately facilitating the ...
Huiliang Zhang +16 more
wiley +1 more source
Frontiers in PsychiatryObjectiveOlanzapine is already used to treat patients with major depressive disorder; however, whether complex drug–drug interaction (DDI) has an effect on the pharmacokinetics of people using olanzapine and its initial dosage remains unknown.
Cun Zhang +6 more
doaj +1 more source
Epidemiology of Adult DSM-5 Major Depressive Disorder and Its Specifiers in the United States
JAMA psychiatry, 2018 D. Hasin +7 more
semanticscholar +1 more source
A Replicable and Generalizable Neuroimaging‐Based Indicator of Pain Sensitivity Across Individuals
Advanced Science, EarlyView.Humans differ in their sensitivity to pain. With six large and diverse fMRI datasets (total N = 1046), this study finds that such individual differences in pain sensitivity can be tracked by fMRI responses to painful stimuli. A highly generalizable machine learning model is further built to predict pain sensitivity across all datasets and analgesic ...
Li‐Bo Zhang +7 more
wiley +1 more source