Results 151 to 160 of about 70,212 (300)

Dual role of spreading depolarization in an epileptic focus

Epilepsia, EarlyView.
Abstract Objective Spreading depolarizations (SDs) are often associated with epileptic discharges. Although SDs are traditionally thought to contribute to postictal depression and termination of epileptic discharges, seizures may also occur during SDs or may even follow SDs, suggesting that interactions between SD and seizures are more complex.
Daria Vinokurova, Karina Tukhvatullina, Roustem Khazipov, Azat Nasretdinov   +3 more
wiley   +1 more source

Correction: Digital Phenotyping for Differential Diagnosis of Major Depressive Episode: Narrative Review. [PDF]

JMIR Ment Health, 2023
Ettore E, Müller P, Hinze J, Riemenschneider M, Benoit M, Giordana B, Postin D, Hurlemann R, Lecomte A, Musiol M, Lindsay H, Robert P, König A.   +12 more
europepmc   +1 more source

An n‐of‐1 gene‐directed drug repurposing trial for an ultrarare genetic condition

Epilepsia, EarlyView.
Abstract Objective Gain‐of‐function (GoF) variants in the KCNC1 potassium channel subunit gene (Kv3.1) cause motor/cognitive delays and hypotonia and have been associated with seizures. Fluoxetine has inhibitory effects on Kv3.1. However, open‐label nonrandomized administration is insufficient to guide clinical decision‐making in ultrarare conditions ...
Vedika Jha, Christina Tsetsos, Mark Bedford, Gregory Costain, Sunita Vohra, Juan Pablo Diaz Martinez, Elise Heon, Jacob Vorstman, Carolina Gorodetsky, Ajoy Vincent, Jesiqua Rapley, Lori Anderson, Evdokia Anagnostou, Danielle A. Baribeau   +13 more
wiley   +1 more source

Gender Differences in the Psychopathology of Mixed Depression in Adolescents with a Major Depressive Episode. [PDF]

Curr Neuropharmacol, 2023
Apicella M, Serra G, Iannoni ME, Trasolini M, Maglio G, Andracchio E, Vicari S.   +6 more
europepmc   +1 more source

Add‐on treatment with vinpocetine reduces seizure frequency and improves comorbidities in patients with loss‐of‐function γ‐aminobutyric acid type A receptor variants

Epilepsia, EarlyView.
Abstract Objective The semisynthetic compound vinpocetine has gained attention as a potential precision medicine for developmental and epileptic encephalopathies caused by loss‐of‐function (LoF) variants in γ‐aminobutyric acid type A (GABAA) receptor genes. As a positive allosteric modulator of GABAA receptors, case reports suggest that vinpocetine can
Cathrine E. Gjerulfsen, Vivian W. Y. Liao, Tomasz S. Mieszczanek, Anne V. Jakobsen, Elena Gardella, Kern Olofsson, Marina Nikanorova, Allan Bayat, Sebastian Ortiz, Sarah Weckhuysen, Cecilie Johannessen Landmark, Orrin Devinsky, Mary Chebib, Philip K. Ahring, Guido Rubboli, Rikke S. Møller   +15 more
wiley   +1 more source

Mindfulness meditation increases interictal epileptiform discharges in meditation‐naïve surgical epilepsy patients

Epilepsia, EarlyView.
Abstract Objective Meditation has widely recognized psychological and neuromodulatory benefits, yet its effects on epileptiform activity remain unclear. This study examined whether novice meditation modulates interictal epileptiform discharges (IEDs) in patients with drug‐resistant epilepsy using intracranial electroencephalography (iEEG).
Shweta Soni, Karine Brochu, Paolo Federico, Walter Hader, Julia W. Y. Kam, Fady Girgis   +5 more
wiley   +1 more source

Major Depressive Episode. Clinical and Electroencephalographic Abnormalities

, 2018
Caracterizar las anormalidades electroencefalográficas y su relación con las características clínicas en pacientes con Episodio Depresivo Mayor (EDM). Método: 31 pacientes con diagnóstico de EDM, a quienes se aplicó la escala Hamilton de Depresión para ...
Piña Mosquera, Carmen María, Macias Arismendi, Aura Carolina   +1 more
core  

Multimodal Sleep Measurement and Alignment Analysis in Outpatients With Major Depressive Episode: Observational Study. [PDF]

JMIR Mhealth Uhealth
Mahir A, Luong N, Baryshnikov I, Martikkala A, Isometsä E, Aledavood T.   +5 more
europepmc   +1 more source

Major depressive episode in hospital workers during the Covid-19 pandemic in Brazil. [PDF]

Rev Saude Publica, 2023
Flesch BD, Szortyka ALSC, Carvalho MP, Goularte LM, Delpino FM, Fassa AG.   +5 more
europepmc   +1 more source

Semiology of functional/dissociative seizures in idiopathic generalized epilepsy: An inpatient video‐electroencephalographic study

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to estimate the prevalence and characterize the semiology of co‐occurring functional/dissociative seizures (FDSs) and identify clinical features potentially associated with the development of video‐electroencephalography (video‐EEG)‐diagnosed FDSs in patients with idiopathic generalized epilepsy (IGE ...
Javier Peña‐Ceballos, Kishen Radhakrishna, Tenzin Choekyi, Clodagh O'Keeffe, Mohamed Ali, Alma O'Donnell, Tudor Munteanu, Patrick B. Moloney, Hany El Naggar, Gerard Mullins, Peter Widdess‐Walsh, Ronan D. Kilbride, Norman Delanty, Nuala McNicholas   +13 more
wiley   +1 more source