Results 71 to 80 of about 5,302,267 (293)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Hamad Medical Corporation (HMC) ambulance service major incident response guide

, 2016
Background: Qatar Hamad Medical Corporation Ambulance Service (HMCAS) major incident response guide is intended to address techniques in field operations that must be utilized in the event of a major incident.
Sami Saleh Alshorman, Mohamad Khenissi, Naven Pullian, Adel Misnad Almuhiarat, Philip Bruyn   +4 more
core   +1 more source

Patients’ safety in adult ICUs: Registered nurses’ attitudes to critical incident reporting

International Journal of Africa Nursing Sciences, 2018
Globally, patients’ safety is a major concern, with ongoing attempts to address the challenge of critical incident reporting. Patients in Intensive Care Units (ICUs) are highly dependent, more prone to unintentional harm, and could benefit from incident ...
T.M. Mjadu, M.A. Jarvis
doaj   +1 more source

Automated classification of primary care patient safety incident report content and severity using supervised machine learning (ML) approaches

Health Informatics Journal, 2020
Learning from patient safety incident reports is a vital part of improving healthcare. However, the volume of reports and their largely free-text nature poses a major analytic challenge.
Huw Prosser Evans, Athanasios Anastasiou, Adrian Edwards, Peter Hibbert, Meredith Makeham, Saturnino Luz, Aziz Sheikh, Liam Donaldson, Andrew Carson-Stevens   +8 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Rural hospital incident command leaders’ perceptions of disaster preparedness

BMC Emergency Medicine
Background Recent trends indicate that the frequency of major incidents (MIs) is increasing. Healthcare systems are vital actors in societies’ responses to MIs. Well-prepared healthcare systems may mitigate the effects of MIs.
Jason P. Murphy, Clara Bergström, Lina Gyllencruetz   +2 more
doaj   +1 more source

Aortic Calcification Onset and Progression: Association With the Development of Coronary Atherosclerosis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundThoracic aortic calcification (TAC) and coronary artery calcification (CAC) are markers of subclinical atherosclerosis and are associated with incident major cardiovascular events.
Hagen Kälsch, Nils Lehmann, Susanne Moebus, Barbara Hoffmann, Andreas Stang, Karl‐Heinz Jöckel, Raimund Erbel, Amir A. Mahabadi   +7 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Peripheral Endothelial Dysfunction Is Associated With Incident Major Depressive Disorder

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background A subset of individuals with major depressive disorder (MDD) have a high burden of cardiovascular risk factors and cerebral small‐vessel disease, implicating vascular disease in the development of depression.
Jaskanwal D. S. Sara, Nazanin Rajai, Scott Breitinger, Betsy Medina‐Inojosa, Lilach O. Lerman, Francisco Lopez‐Jimenez, Amir Lerman   +6 more
doaj   +1 more source