Results 201 to 210 of about 1,104 (244)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

PHLOWER leverages single-cell multimodal data to infer complex, multi-branching cell differentiation trajectories. [PDF]

open access: yesNat Methods
Cheng M   +11 more
europepmc   +1 more source

Major construction entails major demolition

Developmental Cell, 2022
Embryonic cells of the early mouse embryo become hypersensitive to apoptotic stimuli before gastrulation. In this issue of Developmental Cell, Pernaute et al. show that this switch in sensitivity is a result of a change in mitochondrial dynamics and mitophagy levels controlled by DRP1, a regulator of mitochondrial fission.
Korotkevich, Ekaterina, Hiiragi, Takashi
openaire   +2 more sources

Callisthene major var. major var. major

2022
1.1. Callisthene major var. major Na área de estudo esta espécie foi coletada em regiões de matas de encosta. Material selecionado: BRASIL, GOIÁS, Corumbá de Goiás, levantamento do Santuário do Morro do Cabeludo, 12.IX.1991, est., P.E.A.M. de Oliveira 1613 (HEPH); Pirenópolis, Serra dos Pireneus, local denominado Casa dos Reis no alto do morro, 15° 47’
Teixeira, Rayna Chaves   +1 more
openaire   +1 more source

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