Results 191 to 200 of about 265 (236)

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

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Retaining majors through the introductory sequence

Proceedings of the 38th SIGCSE technical symposium on Computer science education, 2007
Retention is an important issue for Computer Science Departments. In many cases students leave the major due to frustrations with programming in the complex languages often used in CS1 and CS2 or because they do not understand that computer science is much more than programming.
Elise H. Turner, Erik Albert, Roy M. Turner, Laurence Latour   +3 more
openaire   +1 more source

Power Majorization and Majorization of Sequences

Results in Mathematics, 1988
Let \(x,y\in R^ n_+\) be such that \(x_ 1\geq...\geq x_ n\), \(y_ 1\geq...\geq y_ n\) and \(\sum x_ i=\sum y_ i.\) We say that x is power majorized by y if \(\sum x^ p_ i\leq \sum y^ p_ i\) for all real \(p\not\in [0,1]\) and \(\sum x^ p_ i\geq \sum y^ p_ i\) for \(p\in [0,1]\). Let \(\phi\) : [0,\(\infty)\to R\) be a continuous function.
openaire   +1 more source

Sequence microheterogeneity of parvalbumin, the major fish allergen

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2013
The microheterogeneity of amino acid sequence observed in various allergens may affect immune response, but incidence of sequence microheterogeneity in allergens and its relation to their allergenicity are unclear. The occurrence of sequence microheterogeneity in major fish allergen, parvalbumin (PA), has been explored using bioinformatics approaches ...
Lapteva, Yulia S., Uversky, Vladimir N., Permyakov, Sergei E.   +2 more
openaire   +3 more sources

Determination of mouse major asialoglycoprotein receptor cDNA sequence

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1993
Hepatic lectins (asialoglycoprotein receptors) specifically recognize galactose-terminated glycoproteins and mediate endocytosis of these molecules. We now report the cloning and sequence of a cDNA encoding murine asialoglycoprotein receptor. It shows high homology with rat and human major receptor forms designated RHL-1 and HHL-1, respectively.
R, Takezawa, K, Shinzawa, Y, Watanabe, T, Akaike   +3 more
openaire   +2 more sources

Majorizing Sequences for Nonlinear Fredholm–Hammerstein Integral Equations

Studies in Applied Mathematics, 2017
AbstractWe use the method of majorizing sequences to study the applicability of Newton's method to solve nonlinear Fredholm–Hammerstein integral equations. For this, we use center convergence conditions on points different from the starting point of Newton's method, which is the point usually used by other authors until now when center conditions are ...
José A. Ezquerro, Miguel A. Hernández‐Verón   +1 more
openaire   +2 more sources