Mathematical Modeling of the Role of Cytokines in Sindbis Virus Treatment of Glioblastoma. [PDF]
ABSTRACT Oncolytic viruses, specifically Sindbis virus (SINV), combined with cytokines show promising results in slowing glioma progression, but a quantitative understanding of their effects remains limited. In this study, we use an ordinary differential equation (ODE) model to examine the effect of adding cytokines to oncolytic SINV therapy.
Makam S, Dobrovolny HM.
europepmc +2 more sources
Post-Traumatic Diaphragmatic Hernia Presenting as Bowel Obstruction 12 Years After a Chest Gunshot Wound: A Rare Delayed Diagnosis. [PDF]
Post‐traumatic diaphragmatic hernia (PTDH) is defined as the migration of intra‐abdominal organs into the chest through a pathological defect in the diaphragm caused by trauma. PTDH is a rare condition, occurring in 3%–7% of all thoracoabdominal injuries. Approximately 14.6% of PTDH cases present months to years after the initial trauma.
Faye PM +12 more
europepmc +2 more sources
tPA-GFP is a reliable probe for detecting compound exocytosis in human pancreatic β-cells. [PDF]
Tissue plasminogen activator tagged to GFP (tPA‐GFP) specifically enables the labelling of insulin granules, a type of large dense‐core vesicle of the pancreatic β cells. When compared to other markers widely used to understand the behavior of insulin granules, tPA enabled the detection of the most number of simple (blue arrow) and compound exocytotic (
Makam AA +5 more
europepmc +2 more sources
Molecular Hybrids of Quinoline and Sulfonamide: Design, Synthesis and in Vitro Anticancer Studies. [PDF]
Diversely functionalized molecular hybrids of quinoline and sulfonamide are designed. Interestingly, all the molecules have exhibited IC50 value >50 against the non‐cancer cells (MRC‐5 and BJ), which indicates the promising non‐cytotoxic nature of the molecules.
Panduranga P +5 more
europepmc +2 more sources
Multienzyme (3-in-1)-Mimicking a Single Nucleobase-Derived Bionanozyme for Versatile Environmental and Biomedical Applications. [PDF]
This study reports the development of bioinspired 2D crystalline Bionanozyme derived from a single nucleobase. It effectively mimics multienzyme activity to detect and remove phenolic pollutants, identify disease biomarkers with high sensitivity, and protect cells from oxidative stress.
Vishwakarma S +8 more
europepmc +2 more sources
Design of a bioaugmented soil aquifer treatment for efficient removal of p‐nitrophenol
Abstract Secondary effluent reclamation and reuse is an effective solution to the water shortage problem, and the safety of reused water is a matter of increasing concern. p‐Nitrophenol (PNP), a common secondary effluent pollutant, can be efficiently removed using the eco‐friendly bioaugmented soil aquifer treatment (SAT) system at the laboratory scale.
Min Shi +4 more
wiley +1 more source
The pleasures of ambiguity: pedagogy and musical apprenticeship in an Istanbul art studio
Abstract ‘Dealing with ambiguity’ has become a pressing concern in many spheres of contemporary life, often presented as a ‘survival skill’ in an uncertain world. Working with ambiguity also plays a crucial role in the musical pedagogy of the Ottoman‐Turkish ney (Sufi reed flute), the playing of which I discuss in this article. Rather than a constraint
Banu Şenay
wiley +1 more source
Abstract Randomized controlled trials (RCTs) remain the gold standard to evaluate clinical interventions, producing the highest level of evidence while minimizing potential bias. Inadequate recruitment is a commonly encountered problem that undermines the completion and generalizability of RCTs—and is even more challenging when enrolling amidst a ...
Kelly Hu +11 more
wiley +1 more source
Abstract Heavy metals have been widely applied in industry, agriculture, and other fields because of their outstanding physics and chemistry properties. However, heavy metal pollution is inevitable in the process of mass production and emission.
Guangda Xu, Peng Song, Lixin Xia
wiley +1 more source
A computational analysis of Turkish makam music based on a probabilistic characterization of segmented phrases [PDF]
This study targets automatic analysis of Turkish makam music pieces on the phrase level. While makam is most simply defined as an organization of melodic phrases, there has been very little effort to computationally study melodic structure in makam music
Baron, Jody L +7 more
core +6 more sources

