Results 101 to 110 of about 680,654 (305)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Interaction among children with special needs in free-play situations: possibilities of development / Interação entre crianças com necessidades especiais em contexto lúdico: possibilidades de desenvolvimento

Psicologia: Reflexão e Crítica, 2008
The present study discussed the role of peer interaction, in a free-play situation, to the development of children with special needs. The interactions between visually impaired children (low vision or blindness), most of them with additional organic ...
Carolina Molina Lucenti de Souza, Cecilia Guarnieri Batista   +1 more
doaj  

Make/Believe: UK design for performance 2011 – 2015 [PDF]

Curator of selected UK work at the Prague Quadrennial, Prague, Czech Republic, 17 – 28 June ...
Burnett, K
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Models and Fiction [PDF]

, 2007
Articl
Frigg, Roman
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

An Island of Amplification in the Ocean of Acceleration

Национальный психологический журнал
Background. The idea of amplification of child development as a focus of Early Childhood Education first introduced by L. S. Vygotsky’s colleague A. V. Zaporozhets presents a logical extension of Vygotsky's concept of the Zone of Proximal Development and
Elena V. Bodrova , Deborah J. Leong
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Immersion is Attention / Becoming Immersed [PDF]

Children sometimes lose themselves in make-believe games. Actors sometimes lose themselves in their roles. Readers sometimes lose themselves in their books.
Liao, Shen-yi
core  

Children’s Television and Emotional Literacy [PDF]

, 2012
Sesame Street and Mr. Rogers’ Neighborhood both promote the social and emotional learning of preschoolers, leading to lifelong positive effects. Daniel Tiger’s Neighborhood has recently been created to replace Mr.
Williamson, Diane
core   +1 more source