Results 131 to 140 of about 3,716,942 (293)

α2,3‐Sialyltransferase (ST3Gal1) regulates endometrioid‐type epithelial ovarian cancer cell migration and invasion via VEGF‐R2/JAK2/STAT3 signaling cascades

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To investigate the role of ST3 β‐galactoside α‐2,3‐sialyltransferase 1 (ST3Gal1) and vascular endothelial growth factor receptor 2 (VEGF‐R2) in endometrioid‐type epithelial ovarian cancer (E‐OC) because aberrant α2,3‐sialylation mediated by ST3Gal1 and VEGF‐R2‐related angiogenesis is linked with tumor progression. Methods ST3Gal1 and
Wei‐Ting Chao   +5 more
wiley   +1 more source

Bioinorganic Site‐Specific Conjugation of Multi‐Arm Linkers to Create Pharmaceuticals With Targeting and Effector Functions

open access: yesJournal of the Chinese Chemical Society, EarlyView.
This Account showcases a modular, multi‐arm linker platform that decouples payload loading from antibody conjugation. By leveraging a computationally designed ACPGHA zinc‐binding motif, we demonstrate the construction of homogeneous antibody‐drug conjugates and theranostic antibody‐radionuclide conjugates with high payload loading. The multi‐arm linker
Cédric Grauffel   +2 more
wiley   +1 more source

Sulfonated Hyaluronic Acid-Based Polymers and Hydrogels Using Thiol-Ene and Thiol-Michael Reactions. [PDF]

open access: yesMacromol Biosci
Beeren IAO   +8 more
europepmc   +1 more source

‘Felt sense of anomaly’‐type transdiagnostic dissociative experiences in adolescents: Endorsed phenomenology and plausible mechanisms

open access: yesJCPP Advances, EarlyView.
Abstract Background Research indicates dissociative experiences (DE) are prevalent in adolescents. However, the exact phenomenology and underlying mechanisms of dissociation in adolescence have yet to be clarified. The current study explores the presentation of, and possible psychological factors maintaining, dissociation in this population.
Emma Černis   +4 more
wiley   +1 more source

Catalytic Triad-Inspired Nanozyme Catalysts for Ester Hydrolysis in Organic Solvent Mixtures. [PDF]

open access: yesACS Catal
Ihara H   +7 more
europepmc   +1 more source

Hidden Markov Quantile Models With Trends for Analysing Air Temperature Data

open access: yesInternational Journal of Climatology, EarlyView.
There is the question of whether climate change, expressed by time‐trends in temperature, is of a heterogeneous nature or not. Here, the time‐trend heterogeneity argument has been investigated using Hidden Markov (HM) quantile time‐trends models in temperature time series.
Georgios Tsiotas   +2 more
wiley   +1 more source

The Hidden Anatomy of Low Back Pain: Uncovering the Impact of Mamillo-Accessory Ligament Ossification. [PDF]

open access: yesJ Funct Morphol Kinesiol
Piper JA   +6 more
europepmc   +1 more source

Neighborhood Deprivation and Voice and Reflux Symptom Burden in a Tertiary Laryngology Cohort

open access: yesThe Laryngoscope, EarlyView.
ABSTRACT Objective The voice handicap index‐10 (VHI‐10) and reflux symptoms index (RSI) are validated, patient‐reported outcome measures (PROMs) commonly used in laryngology to assess the subjective impact of voice disorders and severity of symptoms associated with laryngopharyngeal reflux, respectively.
Sandra Stinnett   +6 more
wiley   +1 more source

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