Results 211 to 220 of about 3,692,753 (275)

<i>Bacillus</i>-Based Biocontrol Agents Mediate Pathogen Killing by Biodegradable Antimicrobials from Macrolactin Family. [PDF]

open access: yesInt J Mol Sci
Guglya EB   +20 more
europepmc   +1 more source

Drivers of decision making in pain diagnosis and treatment: Findings from an ethnographic study of veterinary practice

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Poor pain management in horses is a welfare concern. The ‘diagnosis’ of pain cannot be separated from the broader set of interactions through which it emerges. The interactions that take place during veterinary consultations shape the ways in which, or whether, pain management is discussed.
Rebecca Smith   +3 more
wiley   +1 more source

Outbreak of poisoning by sodium hydrogen methylarsonate (MSMA)—an arsenic‐based herbicide—in horses in Brazil

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Arsenic poisoning in horses is rarely reported in the literature. However, arsenic compounds can be present in rodenticides, pesticides, and herbicides, representing a potential source of accidental exposure for horses. Objective To describe the epidemiological, clinical, and laboratory findings from a herd of 31 horses exposed to ...
Gabriella Faria Pereira   +7 more
wiley   +1 more source

Investigating the molecular mechanisms underlying the anti‐CRISPR function of AcrIIA13b protein

open access: yesThe FEBS Journal, EarlyView.
Anti‐CRISPR protein AcrIIA13b inhibits CRISPR–Cas9 function by preventing target DNA engagement. The Cas9–sgRNA ribonucleoprotein (RNP) normally recognizes the protospacer adjacent motif (PAM) duplex to initiate DNA cleavage. AcrIIA13b binding to the PAM‐interacting WED–PI domain blocks this recognition, leaving the target DNA intact.
So Yeon Lee, Hyun Ho Park
wiley   +1 more source

Dimerization‐dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH signalling inhibitors

open access: yesThe FEBS Journal, EarlyView.
NOTCH signalling is indispensable for tissue homeostasis and, consequently, corruption of its normal function promotes numerous diseases, including cancer. However, the development of targeted therapies has been hampered by inefficacy and overt toxicity. Here, we show that NOTCH receptor dimerization is necessary for receptor transactivation, which has
Xinxin Liu   +9 more
wiley   +1 more source

Anemia‐associated mutations disrupt the CDIN1‐Codanin1 complex in inherited congenital dyserythropoietic anemia I (CDA‐I) disease

open access: yesThe FEBS Journal, EarlyView.
Congenital dyserythropoietic anemia type I (CDA‐I) arises from mutations in Codanin1 and CDIN1. Using quantitative biophysical approaches, we show that disease‐associated mutations disrupt the CDIN1‐Codanin1 complex. Our findings provide critical insights into the molecular mechanism that links protein dysfunction to disturbing chromatin arrangement ...
Martin Stojaspal   +8 more
wiley   +1 more source

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