Results 81 to 90 of about 4,662,197 (248)

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

Advanced Science, EarlyView.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang, Yujing Shi, Zehua Gao, Jing Wang, Changsheng Liu   +4 more
wiley   +1 more source

Development and evaluation of social anxiety based on metacognitive beliefs and early maladaptive schemas mediating by cognitive strategies of emotion regulation in adolescent girls

مجله علوم روانشناختی, 2022
Background: social anxiety is one of the most common and debilitating disorders in the age of education, and has adverse consequences in many aspects of the lives of people with the disorder.
Bayan Ghaderi, Kamran Yazdanbakhsh, Jahangir Karami   +2 more
doaj  

Teachers’ Strategies for Managing Adolescent Students with Maladaptive Behaviours in Ghana

, 2020
Maladaptive behavior is arguably the most common disruptive behaviour among adolescents and in order to transform these students into productive members in the society, the need for quality education cannot be overrated.
Samuel Dontoh, Charles Agyei Amoah, Augustine Adjei, Barnabas Addai Amanfo   +3 more
core   +1 more source

Cloninger’s TCI associations with adaptive and maladaptive emotion regulation strategies [PDF]

, 2019
Background Cognitive emotion regulation plays a crucial role in psychopathology, resilience and well-being by regulating response to stress situations.
Danilo Garcia, Lee, Soo Jin, Soo Jin Lee, Chae, Han, Garcia, Danilo,, Han Chae, Park, Soo Hyun, Soo Hyun Park   +7 more
core   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Coping strategies of Dutch servicemembers after deployment

Military Medical Research, 2019
Background This study examines the relationship between coping strategies and symptoms of anxiety or depression among Dutch servicemembers deployed to Afghanistan. Methods Coping strategies were assessed in 33 battlefield casualties (BCs) and the control
Loes G. M. de Kruijff, Olivia R. M. Moussault, Marie-Christine J. Plat, Rigo Hoencamp, Peter van der Wurff   +4 more
doaj   +1 more source

A Photothermally Amplified Enzyme–Nitric Oxide Co‐Regulatory System Reprograms Pathological ECM–Fibroblast Crosstalk to Alleviate Hypertrophic Scarring

Advanced Science, EarlyView.
An enzyme–nitric oxide (NO) co‐regulatory strategy reprograms pathological extracellular matrix (ECM)–fibroblast crosstalk in hypertrophic scars. Enzymatic degradation of pre‐existing ECM relieves aberrant mechanical cues, while NO‐mediated fibroblast phenotypic modulation restrains excessive collagen synthesis.
Junzhe Fu, Fan Jia, Yixian Mu, Wanzhe Liu, Dingqi Tang, Qiao Jin, Jian Ji, Youxiang Wang   +7 more
wiley   +1 more source

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

Unravelling the Distinct Phenotype and Mechanosensitive Properties of Different Tendon Cell Populations

Advanced Science, EarlyView.
Tendon interfascicular and fascicular matrix cells are isolated and cultured, revealing distinct phenotypes and mechanosensitive responses. Interfascicular matrix cells exhibit marked stiffness‐dependent phenotypic plasticity, whereas fascicular matrix cells remain comparatively stable.
S. E. Grossemy, D. E. Zamboulis, N. S. Khatib, M. R. Fazal, C. C. Gains, A. Giannopoulos, T. Hopkins, C. Bevan, Y. Aggarwal, M. M. Knight, H. R. C. Screen   +10 more
wiley   +1 more source

Stress Response and Perinatal Reprogramming: Unraveling (Mal)adaptive Strategies

Neural Plasticity, 2016
Environmental stressors induce coping strategies in the majority of individuals. The stress response, involving the activation of the hypothalamic-pituitary-adrenocortical axis and the consequent release of corticosteroid hormones, is indeed aimed at ...
Laura Musazzi, Jordan Marrocco
doaj   +1 more source