Results 151 to 160 of about 137,891 (245)

C1′‐Branched Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium Falciparum 6‐Oxopurine Phosphoribosyltransferase

ChemMedChem, Volume 20, Issue 19, October 6, 2025.
Novel C1'‐branched acyclic nucleoside phosphonates were synthesized. The compounds are inhibitors of Plasmodium falciparum and human 6‐oxopurine phosphoribosyltransferases with Ki values as low as 0.4 µM and 0.7 µM, respectively. A phosphonodiamidate prodrug exhibited IC50 = 4.3 µM against a drug‐sensitive strain of P.
Jan Frydrych, Dianne T. Keough, Haojun Xia, Lenka Poštová Slavětínská, Martin Dračínský, Michal Česnek, Jye Travis, Marina Chavchich, Michael Edstein, Dana Hocková, Luke W. Guddat, Zlatko Janeba   +11 more
wiley   +1 more source

Translation of a Human‐Based Malaria‐on‐a‐Chip Phenotypic Disease Model for In Vivo Applications

Advanced Science, Volume 12, Issue 38, October 13, 2025.
Inoculation of the Malaria‐on‐a‐Chip model with human erythrocytes infected with Plasmodium falciparum can support the entire intraerythrocytic lifecycle for 7 days in vitro. Utilizing this human‐based, serum‐free model provides an alternative to animal testing by introducing a human‐based, preclinical alternative for antimalarial therapeutic delivery.
Michael J. Rupar, Hannah M. Hanson, Brianna L. Botlick, Narasimhan Sriram, Stephanie Rogers, Justin Zuniga, Zhanhe Liu, Steven J. Trimmer, Joseph M. Ciurca, Christopher J. Long, Christopher W. McAleer, Stephan Schmidt, Paola Favuzza, Philip Lowe, Nathalie Gobeau, James J. Hickman   +15 more
wiley   +1 more source

Neopterin as a Tool for Primate Ecoimmunology: Current Knowledge, Practical Application, and New Directions From Captivity to the Wild

American Journal of Primatology, Volume 87, Issue 10, October 2025.
Neopterin is a sensitive and specific biomarker of intracellular pathogen infection and chronic inflammation, and affected by environmental, life‐history, and sex‐contextual factors. This review offers best‐practice guidelines and practical advice on sample collection, storage, and analysis in primates when used for ecoimmunological conservation and ...
Verena Behringer, Caroline Deimel
wiley   +1 more source

Immunofluorescence study of cytoskeleton in endothelial cells induced with malaria sera

Malaria Journal
Background Endothelial cells (ECs) play a major role in malaria pathogenesis, as a point of direct contact of parasitized red blood cells to the blood vessel wall.
Mathusorn Wongsawat, Supattra Glaharn, Charit Srisook, Wilanee Dechkhajorn, Urai Chaisri, Chuchard Punsawad, Tachpon Techarang, Kesinee Chotivanich, Srivicha Krudsood, Parnpen Viriyavejakul   +9 more
doaj   +1 more source

Oligochitosan Conjugates of the Antimalarials Dihydroartemisinin and Lumefantrine: Synthesis, Stability, Cell Viability, and Antiplasmodial Studies

Applied Research, Volume 4, Issue 5, October 2025.
Schematic representation of orally administered antimalarial–oligochitosan conjugates. The mucoadhesive properties of oligochitosan facilitate enhanced drug absorption across the intestinal epithelium (Image created in BioRender.com & Microsoft 365 PowerPoint).
William Matshe, Sindisiwe Mvango, Rudzani Malabi, Asongwe Tantoh, Charlene Andraos, Ibukun Famuyide, Lyndy McGaw, Sooraj Baijnath, Lynne Pilcher, Mohammed Balogun   +9 more
wiley   +1 more source

Falciparum malaria in ICU [PDF]

Critical Care, 2000
A Aaron, B Avinash
openaire   +2 more sources

Generalized Tetanus Associated With Malaria and Probable Meningitis in a 4‐Year‐Old Patient: A Case Report in Limbe Regional Hospital, Cameroon

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Tetanus is a life‐threatening disease preventable by immunization through vaccines. In resource‐limited settings, its association with other acute infections should be managed cautiously. A 4‐year‐old unvaccinated male was referred from a nearby hospital for better management of severe malaria and probable enteric fever, after presenting there
Christian Damien Tchuisseu Ngapjang, Christian Fotso, Ronald Gobina, Philippe Albert Lingo, Quincy‐Jones Shumbang Tchumukong, Bertold Brecht Kouam, Marc Effila, Emelinda Berinyuy Nyuydzefon, Verla Vincent Siysi   +8 more
wiley   +1 more source

Malaria in Pregnancy and Predisposing Factors in Jor District of Gambella Region, Southwest Ethiopia: A Cross‐Sectional Study

Health Science Reports, Volume 8, Issue 10, October 2025.
ABSTRACT Background and Aims Malaria in pregnancy remains a major public health concern in Ethiopia, particularly in high‐endemic regions like Gambella. Despite the high burden, no peer‐reviewed published study exists on its prevalence and associated risk factors among pregnant women in Jor District, Gambella region.
Okwom Oguta, Jemal Mohammed, Ukash Umer, Ephrem Tefera Solomon   +3 more
wiley   +1 more source

Unstained Blood Smear Analysis: A Review of Rule‐Based, Machine Learning, and Deep Learning Techniques

Journal of Biophotonics, Volume 18, Issue 10, October 2025.
Bright‐field images of unstained smears. (1) Sparse erythrocytes allow straightforward intensity‐ or phase‐based segmentation. (2) Overlapping cells blur boundaries, causing over‐ or under‐segmentation and lowering rule‐based accuracy, thus motivating overlap‐aware algorithms for reliable downstream feature extraction and classification. ABSTRACT Blood
Husnu Baris Baydargil, Thomas Bocklitz
wiley   +1 more source

Preliminary assessment of serum endocan as a biomarker of disease severity in Plasmodium falciparum and Plasmodium vivax malaria

Malaria Journal
Background Endocan, a component of endothelial glycocalyx, is a recognized biomarker of endothelial dysfunction in various inflammatory and infectious diseases.
Kwannan Nantavisai, Srisombat Puttikamonkul, Parnpen Viriyavejakul   +2 more
doaj   +1 more source