Results 91 to 100 of about 869,297 (419)

Ranking malaria risk factors to guide malaria control efforts in African highlands. [PDF]

, 2009
INTRODUCTION: Malaria is re-emerging in most of the African highlands exposing the non immune population to deadly epidemics. A better understanding of the factors impacting transmission in the highlands is crucial to improve well targeted malaria ...
Baza, Dismas, Coosemans, Marc, D'Alessandro, Umberto, Protopopoff, Natacha, Speybroeck, Niko, Van Bortel, Wim, Van Geertruyden, Jean-Pierre   +6 more
core   +4 more sources

Halofuginone Disrupted Collagen Deposition via mTOR‐eIF2α‐ATF4 Axis to Enhance Chemosensitivity in Ovarian Cancer

Advanced Science, EarlyView.
COL1A1, a major component of ECM, contributes to chemoresistance and poor prognosis in ovarian cancer. Halofuginone (HF) attenuates CAF‐secreted COL1A1 through mTOR‐eIF2α‐ATF4 axis. Notably, HF disrupts collagen deposition to form the looser ECM and facilitates CD8+ T cell infiltration, partially via M2‐M1 macrophage polarization to enhance ...
Wenxin Li, Yenan Wu, Yanan Zhang, Wenyan Gao, Xin Li, Haixia Luo, Mengmeng Lu, Zhihua Liu, Aiping Luo   +8 more
wiley   +1 more source

Insect‐specific viruses used in biocontrol of mosquito‐borne diseases

Interdisciplinary Medicine, Volume 1, Issue 1, January 2023., 2023
Insect‐specific RNA viruses (ISRVs) are involved in a wide range of families including Flaviviridae, Bunyaviridae, Negeviruses, Togaviridae, Reoviridae, Mesoniviridae, and Rhabdoviridae, which cannot infect vertebrates, including humans. However, ISRVs can infect and replicate in mosquitoes, interfering with the replication of mosquito‐borne viruses ...
Jiating Chen, Shengqun Deng, Hongjuan Peng   +2 more
wiley   +1 more source

Graphene in the fight against malaria [PDF]

arXiv, 2020
Malaria infection is a major public health worldwide, with millions of new cases and creating huge direct (an indirect) economic losses annually. Thus, the availability of preventive methods and diagnostic solutions for malaria is critical to save many lives, especially in poor countries.
arxiv  

A spatial predictive model for Malaria resurgence in central Greece integrating entomological, environmental and Social data [PDF]

, 2017
Malaria constitutes an important cause of human mortality. After 2009 Greece experienced a resurgence of malaria. Here, we develop a modelbased framework that integrates entomological, geographical, social and environmental evidence in order to guide the mosquito control efforts and apply this framework to data from an entomological survey study ...
arxiv   +1 more source

End-to-end Malaria Diagnosis and 3D Cell Rendering with Deep Learning [PDF]

arXiv, 2021
Malaria is a parasitic infection that poses a significant burden on global health. It kills one child every 30 seconds and over one million people annually. If diagnosed in a timely manner, however, most people can be effectively treated with antimalarial therapy. Several deaths due to malaria are byproducts of disparities in the social determinants of
arxiv  

Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study [PDF]

, 2018
Background: Human genetic factors are important determinants of malaria risk. We investigated associations between multiple candidate polymorphisms—many related to the structure or function of red blood cells—and risk for severe Plasmodium falciparum ...
Alexander, W Macharia, Anna, Jeffreys, Bancone, G., Benjamin, Tsofa, Carolyne, M Ndila, Christina, Hubbart, Dominic, P Kwiatkowski, Gavin, Band, Geraldine, Clarke, Gideon, Nyutu, Hughes, C., John, Ojal, Kate, Rowlands, Kathryn, Maitland, Kennedy, O Awuondo, Kevin, Marsh, Kirk, A Rockett, Malariagen, Consortium, Mangano, V., Margaret, Mackinnon, Modiano, David, Mohammed, Shebe, Neema, Mturi, Norbert, Peshu, Nuno, Sepúlveda, Silvia, Kariuki, Sophie, Uyoga, Taane, G Clark, Thomas, N Williams   +28 more
core   +1 more source

Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen‐Derived Extracellular Vesicles

Aggregate, EarlyView.
Pathogen‐derived extracellular vesicle detection: theoretical insights and advanced methodologies: This review explores the theoretical foundations and practical applications of pEV detection, emphasizing the challenges and innovative strategies involving novel aggregate materials and machine learning for enhanced diagnostic accuracy.
Lihan Lai, Yun Su, Cong Hu, Zehong Peng, Wei Xue, Liang Dong, Tony Y. Hu   +6 more
wiley   +1 more source

A quasi-experimental study to estimate effectiveness of seasonal malaria chemoprevention in Aweil South County in Northern Bahr El Ghazal, South Sudan

Malaria Journal
Background Seasonal malaria chemoprevention (SMC) is an effective intervention to prevent malaria in children in locations where the burden of malaria is high and transmission is seasonal.
Jamshed Khan, Maria Suau Sans, Francis Okot, Abubaker Rom Ayuiel, Jonathan Magoola, Christian Rassi, Sikai Huang, Denis Mubiru, Craig Bonnington, Kevin Baker, Julla Ahmed, Chuks Nnaji, Sol Richardson   +12 more
doaj   +1 more source

Malaria Pathogenesis.

Cold Spring Harbor Perspectives in Medicine, 2018
In the mosquito-human life cycle, the six species of malaria parasites infecting humans (Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale wallickeri, Plasmodium ovale curtisi, Plasmodium malariae, and Plasmodium knowlesi) undergo 10 or more ...
D. Milner
semanticscholar   +1 more source