Results 131 to 140 of about 976,240 (379)

Exploration and Characterization of the Antimalarial Activity of Pyrimidine‐2,4‐Diamines for which Resistance is Mediated by the ABCI3 Transporter

open access: yesChemMedChem, EarlyView.
Investigation of the structure‐activity relationship on W482 (1) with a pyrimidine‐2,4‐diamine scaffold culminated in analog 51 with enhanced anti‐plasmodial activity. Forward genetics and phenotypic examination revealed the ABCI3 transporter protein as a putative resistance mechanism.
Mahta Mansouri   +14 more
wiley   +1 more source

RTS,S/AS02 and the quest of the Holy Grail [PDF]

open access: yes, 2002
High-profile programs under the WHO/Roll Back Malaria initiative, in addition to unravelling the human and malaria parasite genomes, have ensured that malaria vaccine research and development are enjoying an unprecedented boom. So far, the development of
Reithinger, R
core  

The Gates Malaria Partnership: a consortium approach to malaria research and capacity development.

open access: yes, 2012
Recently, there has been a major increase in financial support for malaria control. Most of these funds have, appropriately, been spent on the tools needed for effective prevention and treatment of malaria such as insecticide-treated bed nets, indoor ...
Bhasin, Amit   +2 more
core   +1 more source

Imported malaria in the UK, 2005 to 2016: estimates from primary care electronic health records [PDF]

open access: yes, 2018
Objective To investigate trends in the incidence of imported malaria in the UK between 2005 and 2016. Design Analysis of longitudinal electronic health records (EHRs) in The Health Improvement Network (THIN) primary care database.
Bastaki, Hamad   +3 more
core   +3 more sources

Pathway to Deployment of Gene Drive Mosquitoes as a Potential Biocontrol Tool for Elimination of Malaria in Sub-Saharan Africa: Recommendations of a Scientific Working Group † [PDF]

open access: hybrid, 2018
Stephanie L. James   +14 more
openalex   +1 more source

Validation of a candidate international harmonisation protocol‐compliant measurement procedure for reticulocyte counting using an erythrocyte gating strategy excluding the platelet component

open access: yesCytometry Part B: Clinical Cytometry, EarlyView.
Abstract The International Harmonisation Protocol (IHP) for Reticulocyte Percentage (%Retic) in CLSI‐H44‐A2 is a microscopic procedure performed on a new‐methylene‐blue‐stained blood film (NMB‐IHP). However, IHP‐compliant Measurement Procedures (MPs) based on flow cytometry (FCM) are recommended for practical and accurately assigned reference values ...
Yutaka Nagai   +9 more
wiley   +1 more source

Influence of education and knowledge on perceptions and practices to control malaria in Southeast Nigeria.

open access: yes, 2006
The study was undertaken in southeastern Nigeria to investigate whether the people's level of education and what they know about malaria affects how they seek treatment and prevention for the disease.
Dike, Nkem   +5 more
core   +1 more source

Circumsporozoite proteins of malaria parasites contain a single immunodominant region with two or more identical epitopes. [PDF]

open access: hybrid, 1983
Fidel Zavala   +4 more
openalex   +1 more source

Malaria, malaria and more malaria

open access: yesParasitology Today, 1997
'The proliferation of intemational meetrags focusing on malaria ~s, in part, a reflection of the increased awareness of the scientifc commu,-,ity of the extent of the problem which, despite them significant successes, malaria continues to present. European Commissionsupported researchers have been in the vanguard of recent developments in international
Mons, B.   +2 more
openaire   +2 more sources

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons   +17 more
wiley   +1 more source

Home - About - Disclaimer - Privacy