Results 141 to 150 of about 869,297 (419)

Critical roles of endogenous glucocorticoids for disease tolerance in malaria

, 2019
During malaria, the hypothalamic-pituitary-adrenal (HPA) axis is activated and glucocorticoid (GC) levels are increased, but their essential roles have been largely overlooked.
De Bosscher, Karolien, Opdenakker, Ghislain, Van den Steen, Philippe E., Vandermosten, Leen, Vanhorebeek, Ilse   +4 more
core   +1 more source

In Vitro Antiplasmodial Activity and Chemical Composition of Combretum aculeatum, a Medicinal Plant From Niger

Chemistry &Biodiversity, EarlyView.
Workflow of current study. ABSTRACT Malaria remains a significant public health challenge in Niger, accounting for 5.6% of global malaria‐related deaths. Local medicinal plants are frequently used as traditional treatments for malaria, although their efficacy and safety are often insufficiently investigated.
Souleymane Magagi Damé, Louis Leclercq, Catherine Vonthron‐Sénécheau, Amadou Tidjani Ilagouma, Sergio Ortiz   +4 more
wiley   +1 more source

Receipt of seasonal malaria chemoprevention by age-ineligible children and associated factors in nine implementation states in Nigeria

Malaria Journal
Background As part of implementation quality standards, community distributors are expected to ensure that only age-eligible children (aged 3–59 months) receive seasonal malaria chemoprevention (SMC) medicines during monthly campaigns.
Taiwo Ibinaiye, Kunle Rotimi, Ayodeji Balogun, Adaeze Aidenagbon, Chibuzo Oguoma, Christian Rassi, Kevin Baker, Olusola Oresanya, Chuks Nnaji   +8 more
doaj   +1 more source

Seven-Year Efficacy of RTS,S/AS01 Malaria Vaccine among Young African Children.

New England Journal of Medicine, 2016
BACKGROUND The candidate malaria vaccine RTS,S/AS01 is being evaluated in order to inform a decision regarding its inclusion in routine vaccination schedules. METHODS We conducted 7 years of follow-up in children who had been randomly assigned, at 5 to
A. Olotu, G. Fegan, J. Wambua, George Nyangweso, A. Leach, M. Lievens, D. Kaslow, P. Njuguna, K. Marsh, P. Bejon   +9 more
semanticscholar   +1 more source

Estimating the Malaria Attributable Fever Fraction Accounting for Parasites Being Killed by Fever and Measurement Error [PDF]

arXiv, 2016
Malaria is a parasitic disease that is a major health problem in many tropical regions. The most characteristic symptom of malaria is fever. The fraction of fevers that are attributable to malaria, the malaria attributable fever fraction (MAFF), is an important public health measure for assessing the effect of malaria control programs and other ...
arxiv  

A Silicon Rhodamine‐fused Glibenclamide to Label and Detect Malaria‐infected Red Blood Cells

ChemBioChem, EarlyView.
A far‐red fluorescent silicon rhodamine‐conjugated glibenclamide (SiR‐glib) is synthesized. Labeling experiments in cells reveal the endoplasmic reticulum as the primary target of SiR‐glib, and is applicable to detect malaria‐infected red blood cells.
Claudia Bastl, Cindy M. Close, Ingo Holtz, Blaise Gatin‐Fraudet, Mareike Eis, Michelle Werum, Smilla Konrad, Laura Kneller, Kilian Roßmann, Christiane Huhn, Souvik Ghosh, Julia Ast, Dorien A. Roosen, Martin Lehmann, Volker Haucke, Luc Reymond, David J. Hodson, Philip Tinnefeld, Kai Johnsson, Viktorija Glembockyte, Nicole Kilian, Johannes Broichhagen   +21 more
wiley   +1 more source

Identifying and characterizing high-risk populations in pilot malaria elimination districts in Madagascar: a mixed-methods study

Malaria Journal
Background In Madagascar, the districts of Antsirabe II, Faratsiho and Antsiranana I have relatively low malaria incidence rates and have been selected by the National Malaria Control Programme for pilot elimination strategies.
Elisabeth Gebreegziabher, Andry Raoliarison, Andrinirina Ramananjato, Andriamamonjy Fanomezana, Martin Rafaliarisoa, Sandy Ralisata, Jocelyn Razafindrakoto, Jennifer L. Smith, Jehan Ahmed, Cara Smith Gueye   +9 more
doaj   +1 more source

Prevalence of K13 mutation and Day-3 positive parasitaemia in artemisinin-resistant malaria endemic area of Cambodia: a cross-sectional study

Malaria Journal, 2017
Background The presence of artemisinin-resistant malaria parasites was confirmed in western Cambodia in 2009. In 2013, mutations in the propeller domain of the kelch protein K13 was found to be associated with artemisinin resistance.
Soy Ty Kheang, Siv Sovannaroth, Sovann Ek, Say Chy, Phally Chhun, Sokkieng Mao, Sokomar Nguon, Dy Soley Lek, Didier Menard, Neeraj Kak   +9 more
doaj   +1 more source

“Asymptomatic” Malaria: A Chronic and Debilitating Infection That Should Be Treated

PLoS Medicine, 2016
Roland Gosling and colleagues argue that "asymptomatic" malaria infections have significant health and societal consequences, and propose that they should be renamed "chronic" malaria infections.
I-.Ju Chen, S. Clarke, R. Gosling, B. Hamainza, G. Killeen, A. Magill, W. O'Meara, R. Price, E. Riley   +8 more
semanticscholar   +1 more source

Risk factors for mortality from imported falciparum malaria in the United Kingdom over 20 years: an observational study [PDF]

, 2012
Objectives To determine which travellers with malaria are at greatest risk of dying, highlighting factors which can be used to target health messages to travellers. Design Observational study based on 20 years of UK national data.
Blaze, M, Bradley, D, Checkley, AM, Chiodini, PL, Smith, A, Smith, V, Whitty, CJ   +6 more
core   +3 more sources