Results 41 to 50 of about 1,686,576 (303)

Community knowledge variation, bed-net coverage, the role of a district health care system and their implications for malaria control in Southern Malawi [PDF]

, 2012
This paper presents data on the pattern of knowledge of caregivers, bed-net coverage and the role of a rural district healthcare system, and their implications for malaria transmission, treatment, prevention and control in Chikhwawa, southern Malawi ...
Morse, Tracy, Masangwi, Salule Joseph, Grimason, Anthony, Kazembe, L.N., Ferguson, Neil   +4 more
core   +3 more sources

Efficacy and safety of artemether-lumefantrine (AL) and artesunate-amodiaquine (ASAQ) for the treatment of uncomplicated Plasmodium falciparum malaria among children 6–59 months in three sentinel sites of Sierra Leone, 2021–2022

Malaria Journal
Antimalarial drug resistance leads to increased treatment failures, prolonged illness, and increased mortality. The World Health Organization (WHO) recommends malaria-endemic countries regularly (ideally biennially) assess the efficacy of commonly used ...
Irene Cavros, Francisca Abanyie, Anitta Renitta Yokoe Kamara, Fay Chalobah, Nelson Fofana, Jehan Ahmed, Kwabena Larbi, Culzean Kennedy, Breanna Horton, Marko Bajic, Mashanika Richardson, Bryce Matlock, Jessica McCaffery, Santigie Kanu, David Schnabel, Temitayo S. A. Labor, Shelby Cash, Mateusz Plucinski, James P. Komeh, Musa Sillah-Kanu   +19 more
doaj   +1 more source

Malaria Policy Advisory Committee to the WHO : conclusions and recommendations of March 2013 meeting [PDF]

, 2013
The Malaria Policy Advisory Committee to the World Health Organization met in Geneva, Switzerland from 13 to 15 March, 2013. This article provides a summary of the discussions, conclusions and recommendations from that meeting.Meeting sessions included ...
WHO Malaria Policy Advisory Committee and Secretariat,, WHO Malaria Policy Advisory Committee and Secretariat   +1 more
core   +1 more source

Advances in Aptamer Drug Delivery Systems for Treatment of Glioblastoma

Advanced Science, EarlyView.
Aptamers have remarkable recognition capacity which is suitable for assisting drug delivery for GB. This review demonstrates that aptamers have great potential as targeted therapeutic carriers, conjugated to various therapeutic carriers, using a range of conjugation strategies and chemistries.
Alexandra R. Paul, Alexandra Moreno Mitchell, Dean O'Neil, Yutong Luo, Khuloud T. Al‐Jamal   +4 more
wiley   +1 more source

Mechanism‐Informed Language Modeling and Oxygenated 3D Screening Identify Berberine–Enzalutamide Synergy in Prostate Cancer Models

Advanced Science, EarlyView.
By integrating knowledge‐augmented artificial intelligence with an oxygen‐supplemented 3D screening platform, a synergistic interaction between berberine and enzalutamide is identified. The framework integrates compound mechanisms of action with disease‐relevant signaling context to prioritize candidate combinations and generate testable pathway‐based ...
Chih‐Hui Lo, Katie Shi, Lina Kafadarian, Alexandra Bermudez, Johnny Diaz, Liam Edwards, Yunqi Hong, Ziyi Chen, Hyeonji Hwang, Weihong Yan, Alan Levinson, Robert Damoiseaux, Cho‐Jui Hsieh, Tanya Stoyanova, Andrew S. Goldstein, Neil Y.C. Lin   +15 more
wiley   +1 more source

Attrition, physical integrity and insecticidal activity of long-lasting insecticidal nets in sub-Saharan Africa and modelling of their impact on vectorial capacity

Malaria Journal, 2020
Background Long-lasting insecticidal nets (LLINs) are the primary malaria prevention and control intervention in many parts of sub-Saharan Africa. While LLINs are expected to last at least 3 years under normal use conditions, they can lose effectiveness ...
Olivier Briet, Hannah Koenker, Laura Norris, Ryan Wiegand, Jodi Vanden Eng, Alex Thackeray, John Williamson, John E. Gimnig, Filomeno Fortes, Martin Akogbeto, Anges W. Yadouleton, Maurice Ombok, M. Nabie Bayoh, Themba Mzilahowa, Ana Paula Abílio, Samuel Mabunda, Nelson Cuamba, Elhadji Diouf, Lassana Konaté, Busiku Hamainza, Cecilia Katebe-Sakala, Gabriel Ponce de León, Kwame Asamoa, Adam Wolkon, Stephen C. Smith, Isabel Swamidoss, Mike Green, Salam Gueye, Jules Mihigo, Juliette Morgan, Ellen Dotson, Allen S. Craig, Kathrine R. Tan, Robert A. Wirtz, Tom Smith   +34 more
doaj   +1 more source

Splenic Tropism and Spleen‐Modulated Systemic Inflammation in Acute Plasmodium vivax Malaria

American Journal of Hematology, EarlyView.
ABSTRACT In chronic Plasmodium vivax (Pv) infection, the spleen accounts for over 98% of total‐body parasite biomass. Whether splenic tropism also occurs in acute infection and how the spleen influences pathogenesis have not been systematically explored. In Papua, Indonesia, we compared clinical and hematology data in 24 spleen‐intact and 25 previously
Steven Kho, Hasrini Rini, Noy N. Kambuaya, Syawal Satria, Freis Candrawati, Putu A. I. Shanti, King Alexander, Benediktus Andries, Aisah R. Amelia, Anjana Rai, Kim A. Piera, Agatha M. Puspitasari, Ristya Amalia, Pak Prayoga, Leo Leonardo, Maulina Hafidzah, Theo Situmorang, Dewi S. Margayani, Desandra A. Rahmayenti, Pengxing Cao, Enny Kenangalem, Leily Trianty, Damian Oyong, Julie A. Simpson, Rintis Noviyanti, Pierre A. Buffet, Jeanne R. Poespoprodjo, Nicholas M. Anstey   +27 more
wiley   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Household costs among patients hospitalized with malaria: evidence from a national survey in Malawi, 2012

Malaria Journal, 2017
Background With 71% of Malawians living on
Ian Hennessee, Jobiba Chinkhumba, Melissa Briggs-Hagen, Andy Bauleni, Monica P. Shah, Alfred Chalira, Dubulao Moyo, Wilfred Dodoli, Misheck Luhanga, John Sande, Doreen Ali, Julie Gutman, Kim A. Lindblade, Joseph Njau, Don P. Mathanga   +14 more
doaj   +1 more source

Therapeutic efficacies of artemether-lumefantrine and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum and chloroquine and dihydroartemisinin-piperaquine for uncomplicated Plasmodium vivax infection in Ethiopia

Malaria Journal, 2022
Background Routine monitoring of anti-malarial drugs is recommended for early detection of drug resistance and to inform national malaria treatment guidelines. In Ethiopia, the national treatment guidelines employ a species-specific approach.
Ashenafi Assefa, Hussein Mohammed, Anjoli Anand, Adugna Abera, Heven Sime, Anna A. Minta, Mekonnen Tadesse, Yehualashet Tadesse, Samuel Girma, Worku Bekele, Kebede Etana, Bereket Hailegiorgis Alemayehu, Hiwot Teka, Dereje Dilu, Mebrahtom Haile, Hiwot Solomon, Leah F. Moriarty, Zhiyong Zhou, Samaly Souza Svigel, Bryan Ezema, Geremew Tasew, Adugna Woyessa, Jimee Hwang, Matthew Murphy   +23 more
doaj   +1 more source