Results 111 to 120 of about 2,981,323 (329)

Patterns of inflammatory responses and parasite tolerance vary with malaria transmission intensity

Malaria Journal, 2017
BackgroundIn individuals living in malaria-endemic regions, parasitaemia thresholds for the onset of clinical symptoms vary with transmission intensity. The mechanisms that mediate this relationship are however, unclear.
Temitope W. Ademolue, Yaw Aniweh, K. Kusi, G. Awandare   +3 more
semanticscholar   +1 more source

Wild Animal Suffering Is Not Intractable: A Precautionary Approach to Compassionate Intervention

Journal of Applied Philosophy, EarlyView.
ABSTRACT Wild animals suffer due to human activity, yet natural factors contribute far more significantly to their suffering. In light of this, some propose that we have a pro tanto obligation to intervene in ecosystems to improve wild animal welfare.
Tristan Katz
wiley   +1 more source

Recent Advances in Thalassemia Research: A Comprehensive Assessment From Diagnostic Technologies to Clinical Treatment

Journal of Clinical Laboratory Analysis, EarlyView.
Thalassemia, a common hereditary blood disorder causing impaired globin synthesis and related complications, has seen remarkable progress in recent years due to advancements in genomics and molecular biology. Researchers have identified various gene variants related to thalassemia and improved clinical diagnostic methods, including new genetic testing ...
Chaoqiong Zhou, Ting Chen, Ying Huang, Huali Wang, Dahai He, Feng Wu, Yan Zhang, Lirui Kong   +7 more
wiley   +1 more source

Population modification of Anopheline species to control malaria transmission

Pathogens and Global Health, 2017
Vector control strategies based on population modification of Anopheline mosquitoes may have a significant role in the malaria eradication agenda. They could consolidate elimination gains by providing barriers to the reintroduction of parasites and ...
R. Carballar-Lejarazú, A. James
semanticscholar   +1 more source

Vδ2+ T cell response to malaria correlates with protection from infection but is attenuated with repeated exposure. [PDF]

, 2017
Vδ2+ γδ T cells are semi-innate T cells that expand markedly following P. falciparum (Pf) infection in naïve adults, but are lost and become dysfunctional among children repeatedly exposed to malaria.
Bowen, Katherine, Boyle, Michelle J, Budker, Rachel, Dorsey, Grant, Farrington, Lila A, Feeney, Margaret E, Greenhouse, Bryan, Jagannathan, Prasanna, Kamya, Moses R, Katureebe, Agaba, Lutwama, Fredrick, McIntyre, Tara I, Musinguzi, Kenneth, Nalubega, Mayimuna, Naluwu, Kate, Nankya, Felistas, Rek, John, Sikyomu, Esther   +17 more
core   +2 more sources

Media‐dependent performance of rabies virus‐like particle production under low oxygen tension in baculovirus‐infected Sf9 cells

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Rabies continues to pose a major public health threat, causing approximately 59 000 deaths each year, especially in regions with limited resources where high costs restrict vaccine access. Safer and scalable vaccine platforms, such as virus‐like particles, are promising alternatives, but their production is highly sensitive to ...
Júlia Públio Rabello, Milena Miyu Teruya, Fernanda Angela Correia Barrence, Thaissa Consoni Bernardino, Jaci Leme, Luis Giovani de Oliveira Guardalini, Noemi Nosomi Taniwaki, Soraia Attie Calil Jorge, Eutimio Gustavo Fernández Núñez   +8 more
wiley   +1 more source

Europe's contribution to the evaluation of the use of systemic antimicrobials in the treatment of periodontitis

Periodontology 2000, EarlyView., 2023
Abstract This narrative review celebrates Europe's contribution to the current knowledge on systemically administered antimicrobials in periodontal treatment. Periodontitis is the most frequent chronic noncommunicable human disease. It is caused by dysbiotic bacterial biofilms and is commonly treated with subgingival instrumentation.
David Herrera, Arie Jan van Winkelhoff, Paula Matesanz, Katalina Lauwens, Wim Teughels   +4 more
wiley   +1 more source

Age-patterns of malaria vary with severity, transmission intensity and seasonality in sub-Saharan Africa: a systematic review and pooled analysis.

PLoS ONE, 2010
BackgroundThere is evidence that the age-pattern of Plasmodium falciparum malaria varies with transmission intensity. A better understanding of how this varies with the severity of outcome and across a range of transmission settings could enable locally ...
Ilona Carneiro, Arantxa Roca-Feltrer, Jamie T Griffin, Lucy Smith, Marcel Tanner, Joanna Armstrong Schellenberg, Brian Greenwood, David Schellenberg   +7 more
doaj   +1 more source

Effect of transmission intensity on hotspots and micro-epidemiology of malaria in sub-Saharan Africa

BMC Medicine, 2017
Background Malaria transmission intensity is heterogeneous, complicating the implementation of malaria control interventions. We provide a description of the spatial micro-epidemiology of symptomatic malaria and asymptomatic parasitaemia in multiple ...
Polycarp Mogeni, Irene Omedo, Christopher Nyundo, Alice Kamau, Abdisalan Noor, Philip Bejon, on behalf of The Hotspot Group Authors   +6 more
doaj   +1 more source

High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission

Cell Host and Microbe, 2016
Summary Preventing transmission is an important element of malaria control. However, most of the current available methods to assay for malaria transmission blocking are relatively low throughput and cannot be applied to large chemical libraries. We have
David M. Plouffe, Melanie Wree, Alan Y. Du, S. Meister, Fengwu Li, K. Patra, Aristea A. Lubar, S. Okitsu, E. Flannery, Nobutaka Kato, Olga Tanaseichuk, Eamon Comer, Bin Zhou, K. Kuhen, Yingyao Zhou, D. Leroy, S. Schreiber, Christina A Scherer, J. Vinetz, E. Winzeler   +19 more
semanticscholar   +1 more source