Results 171 to 180 of about 76,469 (250)

Mitochondrial haplotype and sex modulate responses to endurance exercise training

The Journal of Physiology, EarlyView.
Abstract figure legend Using OKC‐HETB/W rats we demonstrate that mitochondrial haplotype influences training responses of endurance exercise. Overall OKC‐HETW rats showed greater responses than OKC‐HETB in exercise tolerance, mitochondrial bioenergetics, mitochondrial DNA (mtDNA) mutation frequencies and motor co‐ordination.
Bumsoo Ahn, Tianhao Wei, Ryan Pettit‐Mee, Eunyoung Kim, Robert V. Musci, Jonathan Wanagat, Hoang Van M. Nguyen, Arlan Richardson, Hyunyoung Kim   +8 more
wiley   +1 more source

A cryptic allosteric pocket shapes isoform-selective inhibition of human malic enzymes. [PDF]

Protein Sci
Krinkel BA, Yosaatmadja Y, Slayton MD, Krinkel A, Copping J, Jeon JH, Eu J, Kohagen K, Ashoorzadeh A, Smaill J, Flanagan J, Walker C, Merajver SD, Loomes K, Squire CJ.   +14 more
europepmc   +1 more source

NAD replenishment restores mitochondrial function and thermogenesis in the brown adipose tissue of mice with obesity

The Journal of Physiology, EarlyView.
Abstract figure legend A high‐fat diet (HFD) induces brown adipose tissue (BAT) whitening, mitochondrial dysfunction (damaged cristae, fragmentation), reduced NAD+ levels and impaired thermogenesis, leading to lower energy expenditure and metabolic inflexibility.
Renata R. Braga, Matheus B. Rocha, Ana P. Morelli, Raul G. da Costa, Marcelo A. S. Mori, Adelino S. R. da Silva, José R. Pauli, Dennys E. Cintra, Eduardo R. Ropelle   +8 more
wiley   +1 more source

AscF in the mycobacterial CIII-CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration. [PDF]

FEBS Lett
Rile E, Diamanti R, Lundin D, Sharma S, Lissner R, Kuil CP, Högbom M, Bald D, Sjöstrand D.   +8 more
europepmc   +1 more source

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

The Journal of Physiology, EarlyView.
Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma, Marta Murgia, Sigitas Kamandulis, Stefano Gastaldello, Marius Brazaitis, Audrius Snieckus, Nerijus Eimantas, Mati Pääsuke, Sebastian Edman, William Apro, Daniel C. Andersson, Håkan Westerblad, Tomas Venckunas   +12 more
wiley   +1 more source

A fungal exudate-inspired substrate mixture elicits an emergent growth phenotype and metabolic responses in <i>Pseudomonas putida</i>. [PDF]

mSystems
Sadler N, Van Fossen E, Black G, Paurus V, Munoz N, Gao Y, Attah IK, Leach D, Kim J, Couvillion S.   +9 more
europepmc   +1 more source

Interplay between store‐operated calcium entry and mitochondrial phosphate handling modulates force and fatigue during exercise

The Journal of Physiology, EarlyView.
Abstract figure legend This study uses systems modelling to demonstrate a role of SOCE in sustained force generation during exercise. SOCE leads to two competing effects on contractile force in myofibres – increased cross‐bridge cycling due to elevated myoplasmic Ca2+$\text{Ca}^{2+}$ enhances force, whereas increased accumulation of myoplasmic ...
Emmet A. Francis, Juliette Hamid, Anusha Kumar, Padmini Rangamani   +3 more
wiley   +1 more source

Dual inhibition of respiratory complexes in <i>Mycobacterium tuberculosis</i> results in bacterial killing. [PDF]

Microbiol Spectr
Chapman CL, Cook GM, McNeil MB.
europepmc   +1 more source

Excessive training does not induce mitochondrial dysfunction or impair insulin signalling within skeletal muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Three weeks of overtraining in trained endurance athletes reduced exercise performance without impairing glucose tolerance. In skeletal muscle, overtraining was associated with increased expression of lipid metabolism‐related proteins, enhanced mitochondrial biogenesis and preserved insulin signalling, despite elevated oxidative ...
Geneviève J. DesOrmeaux, Henver S. Brunetta, Pierre‐Andre Barbeau, Alexandra M. Coates, Christopher Pignanelli, Fasih A. Rahman, Jamie F. Burr, Graham P. Holloway   +7 more
wiley   +1 more source

Abscisic Acid Lowers Postharvest Grape Acidity via PP2C-ALMT9-Dependent Malate Transport. [PDF]

Physiol Plant
Zhou Y, Cheng J, Nong Y, Ahmed N, Gao H, Zhou X, Zheng T, Zhang R, Li Y, Zhou S, Jia H.   +10 more
europepmc   +1 more source