Results 221 to 230 of about 76,469 (250)

Metabolic Flux Analysis Reveals Cell Line‐Specific Rewiring in CHO Cells Following TCA Cycle Intermediate Feeding for Bioprocess pH Control

Biotechnology and Bioengineering, Volume 123, Issue 10, Page 2713-2728, October 2026.
ABSTRACT Chinese hamster ovary (CHO) cells are the leading host for recombinant therapeutic protein production in the biopharma industry. In this study, we investigated how feeding acidic forms of tricarboxylic acid (TCA) cycle intermediates—malic acid, succinic acid, and α‐ketoglutaric acid—affects cell culture performance and metabolism in two ...
Sarah A. Sacco, Kevin J. Ruiz‐Márquez, Rachel Moen, Irina Trenary, Xiaolin Zhang, Xiaowen Wang, Malik Padellan, Henry Lin, Jamey D. Young   +8 more
wiley   +1 more source

Comparative Effects of High-Molecular-Weight Chitosan and Chitosan Oligosaccharide Lactate on Metabolic Adjustment and Salinity Tolerance in <i>Cucumis sativus</i> L. [PDF]

Molecules
Hawrylak-Nowak B, Stasińska-Jakubas M, Sawicki J, Matraszek-Gawron R, Jarmulska W, Czelej-Wrzesień M, Dresler S.   +6 more
europepmc   +1 more source

Challenges and Future Directives of Synthetic Biology in Engineering Plant–Microbe Partnerships for Sustainable Agriculture

Biotechnology and Bioengineering, Volume 123, Issue 10, Page 2491-2519, October 2026.
ABSTRACT Synthetic biology has recently proven to be a valuable tool for enhancing agriculture even in the face of environmental and biological stresses. Understanding the challenges that militate synthetic biology will assist in ensuring safe, stable, and scalable crop production.
Ben Jesuorsemwen Enagbonma, Rebaona Reaobaka Molefe‐Madlaliso, Alaba Adewole Adebayo, Oghoye Priscilla Oyedoh, Godfrey Okainemen Oribhabor, Oluwaseun Emmanuel Shittu, Olubukola Oluranti Babalola   +6 more
wiley   +1 more source

Engineering of the glucose uptake system to increase 2,4-Dihydroxybutyric acid production in <i>Escherichia coli</i>. [PDF]

Metab Eng Commun
Nguyen TAS, Alkim C, Ihle N, Walther T, Frazão CJR.   +4 more
europepmc   +1 more source

Malate matters: disrupting bacterial-type phosphoenolpyruvate carboxylase (BTPC) rewires tomato fruit development. [PDF]

Plant Physiol
Martínez Rivas FJ, Smith MA, Zangishei Z, Alseekh S, Usadel B, Plaxton WC, Fernie AR.   +6 more
europepmc   +1 more source

Computational modeling of substrate-dependent lung mitochondrial respiration and bioenergetics in rats with different susceptibility to hyperoxia-induced ARDS. [PDF]

Am J Physiol Cell Physiol
Taheri P, Dave DD, Clough AV, Dash RK, Audi SH.   +4 more
europepmc   +1 more source

Functional In Vitro Expression of the Succinate-Acetate Transporter SatP and an Initial Screening Strategy. [PDF]

Membranes (Basel)
Yao Y, Schuster B, Vorauer-Uhl K, Mattanovich D.   +3 more
europepmc   +1 more source

Malate-aspartate shuttle inactivation drives pulmonary hypertension through glucose carbon flux rewiring and α-ketoglutarate-dependent epigenetic remodeling. [PDF]

Redox Biol
Wang Y, Liang Q, Gao Y, Geng J, Cheng X, Xin M, Guo D, Sun D, Hu L, Li Y, Jin F.   +10 more
europepmc   +1 more source

Acanthamoeba ATP synthase structure reveals the TCA cycle is tethered to OXPHOS. [PDF]

Cell
Fry MY, Luce BE, Stefely JA, Chen MZ, Deng FG, Issa TM, MitoCarta Tree of Life Consortium, Calvo SE, Samuelson J, Mootha VK, Chao LH.   +10 more
europepmc   +1 more source

Pathway and efflux engineering to utilize endogenous high isoprenoid flux in <i>Azospirillum brasilense</i> Sp7 for sesquiterpene production. [PDF]

Appl Environ Microbiol
Saranga DB, Pooja CK, Singh A, Adarsh MV, Kiran NR, Gowda CU, Kumari P, Ankita, Zehra A, Sharma PM, Mohanty RP, Pragadheesh VS, Nagegowda DA, Mishra MN.   +13 more
europepmc   +1 more source