Results 121 to 130 of about 38,489 (227)

Expanding the MRPS34 Genotype–Phenotype Correlation: Two Novel Cases and a Cohort Review

JIMD Reports, Volume 67, Issue 4, July 2026.
ABSTRACT MRPS34 encodes a mitoribosomal protein essential for mitochondrial translation. Biallelic pathogenic variants in MRPS34 cause Combined Oxidative Phosphorylation Deficiency 32 (COXPD32), a rare mitochondrial disorder within the Leigh syndrome spectrum (LSS), ranging from fatal in infancy to adult survival.
Alberte Aspaas Lundquist, Sumit Parikh, Thomas van Overeem Hansen, Flemming Wibrand, Elsebet Østergaard   +4 more
wiley   +1 more source

Hypothalamic malate dehydrogenase 2 modulates systemic glucose metabolism through oxytocin-mediated thermogenesis. [PDF]

Cell Rep Med
Yao T, Wu G, Zeng Y, Xie Y, Cui X, Zhang Q, Yan C, Cui Z, Gong H, Xiong T, Liang X, Zhang Y, Zheng R, Wang H, Gao M, Zhang P, Wang R, Zhao X, Feng Z, Xiao L, Liu T, Zhang Z.   +21 more
europepmc   +1 more source

Structure–activity relationship study shows versatility in substrate specificity for heterodisulfide reductase in methanogenic archaea

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Hydrogenotrophic methanogens are anaerobic archaea that convert carbon dioxide and hydrogen into methane. Central to this process is the heterodisulfide reductase (Hdr), which catalyzes the reduction of the heterodisulfide made of coenzyme M and coenzyme B. In vivo, Hdr functions in association with electron‐donating modules such as the [NiFe]‐
Mahdi Faal Maleki, Joakim Bøgelund Jakobsen, Eva Danielle Schuiten, Tristan Wagner, André Luis Alves Neves, Lennart Bunch   +5 more
wiley   +1 more source

Large deletions in the DNA primase large subunit PRIM2 are associated with NADP-malate dehydrogenase activity in a porcine F₂ cross. [PDF]

Anim Genet
Falker-Gieske C, Blaj I, Krizanac AM, Kilic I, Reich P, Bennewitz J, Tetens J.   +6 more
europepmc   +1 more source

Triheptanoin - Novel therapeutic approach for the ultra-rare disease mitochondrial malate dehydrogenase deficiency. [PDF]

Mol Genet Metab Rep, 2021
Laemmle A, Steck AL, Schaller A, Kurth S, Perret Hoigné E, Felser AD, Slavova N, Salvisberg C, Atencio M, Mochel F, Nuoffer JM, Gautschi M.   +11 more
europepmc   +1 more source

Advancing Malic Acid Production of Aspergillus oryzae: Combined Process Optimization and Application of Various Substrates

Biotechnology and Bioengineering, Volume 123, Issue 6, Page 1634-1647, June 2026.
ABSTRACT In light of climate change and growing resource scarcity, microbial production of organic acids offers a sustainable alternative to fossil‐based chemical synthesis. In this study, malic acid production by Aspergillus oryzae was optimized through cultivation temperature adjustment and biotin supplementation, while organic acid formation from ...
Lukas Hartmann, Anke Neumann, Dirk Holtmann, Björn Vater, Thomas Hahn, Susanne Zibek, Katrin Ochsenreither   +6 more
wiley   +1 more source

β-Hydroxybutyrate enhances malate dehydrogenase 2 β-hydroxybutyrylation to alleviate hepatic steatosis in MASLD. [PDF]

Cell Mol Life Sci
Cai J, Li W, Wu C, Ni H, Ran H, Huang Y, Tang X, He W, Gu Y, You Y, Li J, Xiao X, Ma L.   +12 more
europepmc   +1 more source

Inhibition of Malate Dehydrogenase-2 Protects Renal Tubular Epithelial Cells from Anoxia-Reoxygenation-Induced Death or Senescence. [PDF]

Biomolecules, 2022
Eleftheriadis T, Pissas G, Golfinopoulos S, Efthymiadi M, Liakopoulos V, Stefanidis I.   +5 more
europepmc   +1 more source

Measuring Calcium Efflux in Isolated Primary Mitochondria

Current Protocols, Volume 6, Issue 6, June 2026.
Abstract Mitochondrial calcium (mCa2+) homeostasis promotes oxidative metabolism within the physiological range; however, dysregulation can trigger necrotic cell death in diseases such as cardiac ischemia‐reperfusion injury, muscular dystrophy, and neurodegenerative disorders, including Alzheimer's disease.
Ta'Aliyah M. Jones, Stephen Hurst, Michael J. Bround   +2 more
wiley   +1 more source

Novel Dual-Coenzyme Specificity and Thermostability of Malate Dehydrogenase Identified in the Cyanobacterium <i>Microcystis aeruginosa</i> PCC7806. [PDF]

Int J Mol Sci
Ge Y, Wu Y, Zhou B, Wu X, Ren Y, Zhu J, Ge Y.   +6 more
europepmc   +1 more source