Results 151 to 160 of about 193,136 (209)

The Effects of Mutations in Malate Dehydrogenase

Looking at the effects of mutating a singular amino acid in the sequence of the enzyme, Malate dehydrogenase (MDH). Determining on a molecular level, why the change in activity occurs.
Denman, Paige
core   +1 more source

Hypothalamic malate dehydrogenase 2 modulates systemic glucose metabolism through oxytocin-mediated thermogenesis. [PDF]

Cell Rep Med
Yao T, Wu G, Zeng Y, Xie Y, Cui X, Zhang Q, Yan C, Cui Z, Gong H, Xiong T, Liang X, Zhang Y, Zheng R, Wang H, Gao M, Zhang P, Wang R, Zhao X, Feng Z, Xiao L, Liu T, Zhang Z.   +21 more
europepmc   +1 more source

The assembly of tetrameric human L‐lactate dehydrogenase is regulated by ionic strength, β‐NADH binding, cyclic peptides, and long‐chain dicarboxylates

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Lactate dehydrogenases catalyze the reduction of pyruvate to lactate, the generation of which is of importance for the energetic metabolism of malignant cells. In particular, human cancer cells overexpress lactate dehydrogenase A (hLDH‐A), whose catalytic activity depends on its assembly into the corresponding homotetramer (denoted as hLDH‐5),
Alessandra Stefan, Luca Gentilucci, Alberto Giuseppe Barbiroli, Valentina Rossi, Hang Liao, Giuseppina Di Stefano, Tingting He, Alejandro Hochkoeppler   +7 more
wiley   +1 more source

Large deletions in the DNA primase large subunit PRIM2 are associated with NADP-malate dehydrogenase activity in a porcine F₂ cross. [PDF]

Anim Genet
Falker-Gieske C, Blaj I, Krizanac AM, Kilic I, Reich P, Bennewitz J, Tetens J.   +6 more
europepmc   +1 more source

Triheptanoin - Novel therapeutic approach for the ultra-rare disease mitochondrial malate dehydrogenase deficiency. [PDF]

Mol Genet Metab Rep, 2021
Laemmle A, Steck AL, Schaller A, Kurth S, Perret Hoigné E, Felser AD, Slavova N, Salvisberg C, Atencio M, Mochel F, Nuoffer JM, Gautschi M.   +11 more
europepmc   +1 more source

Metabolism of methane and propane and the role of the glyoxylate bypass enzymes in Methylocella silvestris BL2 [PDF]

Methylocella silvestris BL2 is a moderately acidophilic facultative methanotroph isolated from forest soil in 2003. Uniquely, it has the ability to grow on a wide range of multi-carbon compounds in addition to methane. An analysis of growth conditions
Crombie, Andrew
core  

Impaired Hepatic Glucose Metabolism Is Associated With Glucose Intolerance in Mice Carrying α2 Isoform Na,K‐ATPase Mutation

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim The Na,K‐ATPase is important for energy demanding cellular processes, including essential components of substrate metabolism and metabolic flexibility. Mice heterozygous for the hemiplegic migraine‐related mutation, G301R, of the Na,K‐ATPase α2 isoform (α2+/G301R) demonstrated altered metabolism in the heart.
Christian Staehr, Tue Duy Nguyen, Tina Myhre Pedersen, Mikkel Vendelbo, Hans Christian Beck, Mads Kjolby, Rajkumar Rajanathan, Elena V. Bouzinova, Niels Jessen, Per Bendix Jeppesen, Alexander V. Chibalin, Vladimir V. Matchkov   +11 more
wiley   +1 more source

β-Hydroxybutyrate enhances malate dehydrogenase 2 β-hydroxybutyrylation to alleviate hepatic steatosis in MASLD. [PDF]

Cell Mol Life Sci
Cai J, Li W, Wu C, Ni H, Ran H, Huang Y, Tang X, He W, Gu Y, You Y, Li J, Xiao X, Ma L.   +12 more
europepmc   +1 more source

Inhibition of Malate Dehydrogenase-2 Protects Renal Tubular Epithelial Cells from Anoxia-Reoxygenation-Induced Death or Senescence. [PDF]

Biomolecules, 2022
Eleftheriadis T, Pissas G, Golfinopoulos S, Efthymiadi M, Liakopoulos V, Stefanidis I.   +5 more
europepmc   +1 more source

The Crosstalk Between Diabetes and Alzheimer's Disease: A Molecular Perspective

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
Increasing evidence indicates an association between type 2 diabetes mellitus and Alzheimer’s disease, contributing to the proposed concept of AD as “type 3 diabetes.” Shared biological features such as impaired insulin signaling, chronic inflammation, mitochondrial dysfunction, and oxidative stress have been observed in both T2DM and AD.
Deniz Catakli, Ozlem Ozen‐Basoglu, Ebru Busra Tuncgovde, Gonen Ozsarlak‐Sozer   +3 more
wiley   +1 more source