Results 81 to 90 of about 1,465 (210)

Metabolic Profiling of Circulating and Tumour‐Infiltrating T Cells Uncovers Bioenergetic Checkpoints Linked With Immune and Clinical Skewing in Melanoma Patients

Immunology, EarlyView.
In this study, we revealed the disturbed metabolic status of circulating and tumour‐infiltrating CD4+ and CD8+ T cells in melanoma patients through targeted metabolomic and lipidomic (on sorted subsets) and at single cell level using the SCENITH method.
Hugo Brouque, Kareem Mahdy, Stephane Mouret, Sylvain Henry, Camille Niveau, Mélanie Cettour‐Cave, Martin Pelosse, Florence de Fraipont, Julie Charles, Andrei Turtoi, Philippe Saas, Caroline Aspord   +11 more
wiley   +1 more source

Genomic variation drives plant flavor diversification

Journal of Integrative Plant Biology, EarlyView.
This review explains how genomic variation shapes plant flavor by altering the biosynthetic and regulatory pathways of key attributes like sweetness, acidity, bitterness, piquancy, astringency, and aroma. It also discusses how multi‐omics, AI‐assisted breeding, and gene editing can translate this knowledge into plants with improved flavor, nutrition ...
Huimin Hu, Yanwei Hao, Yiwei Zhou, Xia Zhang, Rui Xia, Pan Liao   +5 more
wiley   +1 more source

TaHDA1‐mediated histone and non‐histone deacetylation orchestrates drought tolerance in wheat

Journal of Integrative Plant Biology, EarlyView.
The histone deacetylase TaHDA1 is a key regulator linking histone and non‐histone deacetylation with drought adaptation and a potential target for improving drought resilience and grain nutritional quality in wheat. ABSTRACT Drought stress severely constrains wheat (Triticum aestivum L.) growth and productivity.
Jinpeng Li, Danyang Zhao, Xiao Peng, Xinran Wu, Chenji Zhang, Huitao An, Wei Chu, Jingchen Lin, Zehui Liu, Qun Yang, Debiao Liu, Xiaoyu Liu, Wanghongan Jia, Yi Pei, Mingming Xin, Yingyin Yao, Weilong Guo, Huiru Peng, Zhongfu Ni, Qixin Sun, Xingbei Liu, Zhaorong Hu   +21 more
wiley   +1 more source

Light signaling controls chloroplast pyruvate metabolism through the STF1/2–PKP1 module in soybean

Journal of Integrative Plant Biology, EarlyView.
In soybean, light‐responsive proteins switch on GmPKP1, which boosts chloroplast pyruvate production. This increases pigments, photosynthesis, seed oil, pod number, and yield, revealing a new way that light boosts crop productivity. ABSTRACT Light signaling coordinates plant development with metabolism, but the link between photoreceptors and ...
Faming Lin, Xiaoran Wang, Chenhao Zhao, Shaolong Yang, Jingnan Xu, Hongyi Su, Ruixiang Lei, Yilei Xu, Jike Xue, Ming Chang, Fanjiang Kong, Ran Wang   +11 more
wiley   +1 more source

Genome‐scale insights into metabolic streamlining and photosynthetic energy balance in the extremophile green alga Picocystis salinarum (Picocystophyceae, Chlorophyta)

Journal of Phycology, EarlyView.
Abstract Picocystis salinarum is an early‐diverging chlorophyte and the sole described member of the Picocystophyceae, frequently dominating hypersaline and alkaline lakes despite extreme physicochemical constraints. To elucidate the genomic foundations of its ecological success, we generated a fully annotated, chromosome‐scale nuclear genome assembly ...
Claude Lemieux, Christian Otis, Monique Turmel   +2 more
wiley   +1 more source

Regulation by the Transcriptional Regulator YdcI in E. coli and (p)ppGpp‐Dependent Activation of ydcI Expression

Molecular Microbiology, EarlyView.
YdcI, a LysR‐type transcription regulator in Escherichia coli, regulates loci like iraP and mqo. Its expression is induced by (p)ppGpp under stress conditions, and protein levels rise during mid‐exponential growth, connecting its role to stress response and metabolism control. ABSTRACT YdcI, a LysR‐type transcription regulator, has been associated with
Ria Basu Roy, Karin Schnetz
wiley   +1 more source

Transcriptome Analysis Reveals Distinct Molecular Signatures Between Erosive and Non‐Erosive Oral Lichen Planus

Oral Diseases, EarlyView.
ABSTRACT Objectives To identify molecular mechanisms distinguishing the erosive subtype of oral lichen planus (EOLP) from the non‐erosive subtype (NEOLP) through transcriptomic analysis. Methods We analysed bulk RNA‐seq data from 30 buccal mucosa samples (13 EOLP, 17 NEOLP) using differential expression, Gene Set Enrichment Analysis (GSEA ...
Kisung Sheen, Chaerim Song, Kanghyun Kwon, Seoyeon Kim, Hye‐Ji Park, Man S. Kim   +5 more
wiley   +1 more source

Gene Editing of Nicotiana benthamiana Architecture for Space‐Efficient Production of Recombinant Proteins in Closed Environments

Plant Biotechnology Journal, EarlyView.
ABSTRACT Indoor vertical farming (VF) offers practical advantages for the cultivation of plant protein bio‐factories including plant uniformity, product consistency, water/nutrient recycling and production cycles on a year‐round basis. Much progress has been achieved toward the development of innovative systems for artificial lighting, automated ...
Béatrice Giroux, Kristina LeBreux, Louis Feyzeau, Marie‐Claire Goulet, Charles Goulet, Dominique Michaud   +5 more
wiley   +1 more source

Concurrent Measurement of O2 Production and Isoprene Emission During Photosynthesis: Pros, Cons and Metabolic Implications of Responses to Light, CO2 and Temperature

Plant, Cell &Environment, EarlyView.
ABSTRACT Traditional leaf gas exchange experiments have focused on net CO2 exchange (Anet). Here, using California poplar (Populus trichocarpa), we coupled measurements of net oxygen production (NOP), isoprene emissions and δ18O in O2 to traditional CO2/H2O gas exchange with chlorophyll fluorescence, and measured light, CO2 and temperature response ...
Kolby Jeremiah Jardine, Suman Som, Luiza Beraldi Gallo, Jilian Demus, Tomas Ferreira Domingues, Christina Marie Wistrom, Lianhong Gu, Guillaume Tcherkez, Ülo Niinemets   +8 more
wiley   +1 more source

Deciphering Role of Endophytes in Plant Defences and Biotic Stress Resilience Across Families

Plant, Cell &Environment, EarlyView.
ABSTRACT Plant families generate distinct repertoires of specialised metabolites that govern their biotic interactions. Endophytes strengthen host plant defence mechanisms and tolerance to biotic challenges by upregulating metabolite biosynthesis, modifying precursor compounds into more potent forms, or by directly synthesising analogous defence ...
S. Aneeqa Noor, Kavita Verma, Nishu, Barkat Hussain, Vartika Mathur   +4 more
wiley   +1 more source