Results 201 to 210 of about 213,931 (342)

Anemia‐associated mutations disrupt the CDIN1‐Codanin1 complex in inherited congenital dyserythropoietic anemia I (CDA‐I) disease

The FEBS Journal, EarlyView.
Congenital dyserythropoietic anemia type I (CDA‐I) arises from mutations in Codanin1 and CDIN1. Using quantitative biophysical approaches, we show that disease‐associated mutations disrupt the CDIN1‐Codanin1 complex. Our findings provide critical insights into the molecular mechanism that links protein dysfunction to disturbing chromatin arrangement ...
Martin Stojaspal, Tomas Brom, Ivona Nečasová, Tomáš Janovič, Pavel Veverka, Naina Verma, Lukáš Uhrík, Lenka Hernychova, Ctirad Hofr   +8 more
wiley   +1 more source

Rapid identification and methicillin resistance test to <i>Staphylococcus aureus</i> in cerebrospinal fluid by MALDI-TOF MS. [PDF]

Microbiol Spectr
Zhang M, Wang X, Huang W, Ma A, Qin S, Hu D, Hu H, Du X, Zhang K, Zhu S, Xu Y.   +10 more
europepmc   +1 more source

Spatially resolved mapping of histones reveals selective neuronal response in Rett syndrome

The FEBS Journal, EarlyView.
Loss of Mecp2 function is associated with Rett syndrome (RTT). MeCP2 regulates chromatin, yet its influence on histone composition and dynamics is unclear. Combining MALDI‐MSI with LCM–LC–MS/MS, we mapped histone proteoforms across the dentate gyrus, cornu ammonis, and cerebellum in two mouse models of RTT.
Frederike Schäfer, Guiseppa de Rocco, Moritz Völker‐Albert, Ignasi Forne, Nicoletta Landsberger, Axel Imhof, Shibojyoti Lahiri   +6 more
wiley   +1 more source

Integration of MALDI-TOF MS and 16S rRNA Analysis for Identification of Plant-Based Fermentation-Associated Microbiota. [PDF]

Environ Microbiol Rep
Ludwiczak A, Sibińska E, Adamczyk I, Wasicki M, Pryshchepa O, Złoch M, Grygorowicz K, Szultka-Młyńska M, Pomastowski P.   +8 more
europepmc   +1 more source

The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1

The FEBS Journal, EarlyView.
ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu, Maximilian J. L. J. Fürst, Oscar P. Kuipers   +2 more
wiley   +1 more source

Application of machine learning with MALDI-TOF MS for rapid differentiation between methicillin-susceptible and methicillin-resistant Staphylococcus aureus. [PDF]

PLoS Comput Biol
Lin YS, Wong RC, Yu J, Yang K, Wong LC, Leung HF, Cheung IY, Chow VC, Tien N, You BJ, Lai CK, Ip M.   +11 more
europepmc   +1 more source

Targeted, receptor‐mediated delivery of a masked d‐amino acid cell‐penetrating peptide for cell‐specific phototoxicity

The FEBS Journal, EarlyView.
A targeted phototoxic peptide selectively accumulates in cells expressing chemokine‐like receptor 1 (CMKLR1). Phototoxicity of the native peptide is low, but cleavage by lysosomal protease cathepsin B releases a 6‐tetramethylrhodamine (TMR) labeled nona‐ᴅ‐arginine which mediates lysosomal rupture and cell death upon irradiation.
Moritz List, Eva‐Maria Jülke, Annette G. Beck‐Sickinger   +2 more
wiley   +1 more source

Comparison of two MALDI-TOF MS platforms for identification of Trichosporon isolates from patients in a tertiary hospital in Hefei, China. [PDF]

BMC Infect Dis
Xu J, Li T, Tang L, Li Y, Wang B, Huang Y, Xu Y.   +6 more
europepmc   +1 more source

Flavobacterium oreochromis From Farmed Tambaqui (Colossoma macropomum): Insights Into Genetic, Phenotypic and Pathogenic Diversity

Journal of Fish Diseases, Volume 49, Issue 7, July 2026.
ABSTRACT Flavobacterium spp. are the etiological agents of columnaris disease. Although there is evidence that columnaris poses a significant threat to the farming of tambaqui (Colossoma macropomum), there remains a large gap in understanding the genetic and phenotypic diversities of columnaris‐causing bacteria (CCB).
Elcimara Cardoso Pereira, Mariluce dos Reis Ferreira, Suzana Kotzent, Luiz Fagner Ferreira Nogueira, Guilherme Campos Tavares, Henrique César Pereira Figueiredo, Fabiana Pilarski, Gustavo Moraes Ramos Valladão, Sílvia Umeda Gallani   +8 more
wiley   +1 more source

Prediction of KPC-producing <i>Klebsiella pneumoniae</i> by MALDI-TOF MS, ensemble learning, and spectral peak annotation. [PDF]

J Clin Microbiol
Rodriguez-Temporal D, Gutiérrez-Pareja M, Gordy GG, Nahkala EM, Rodríguez-Sánchez B, Patel R.   +5 more
europepmc   +1 more source