Results 71 to 80 of about 67,841 (262)

Spatiotemporally Controlled Sequential Chemo‐Immunotherapy Activates Pyroptosis for Robust Anti‐Tumor Immunotherapy

Advanced Science, EarlyView.
A glutathione and ultrasound dual‐responsive cerasome achieves sequential co‐delivery of gemcitabine and BMS1166 in tumors. Chemotherapy priming followed by on‐demand PD‐L1 blockade synergistically amplifies anti‐tumor immunity, inhibiting primary tumor growth, distant metastasis and inducing durable immune memory.
Suhui Sun, Ruiqi Wu, Qingshuang Tang, Yunli Xu, Wanrui Shi, Mengxin Wang, Haonan Wang, Yan Luo, Cheng Ma, Xiaolong Liang   +9 more
wiley   +1 more source

Substrate‐Dependent Crosslinking by the Cytochrome P450 From Aminopyruvatide Biosynthesis

Angewandte Chemie, EarlyView.
Substitutions in the aminopyruvatide precursor peptide altered the C─C linkage formed from a YLY motif by the P450 ApyO to a N─C linkage in a WLY motif. Moreover, constitutional isomers crosslinked by C─C and C─O linkages were formed from YYY or YWY motifs. ABSTRACT Cytochrome P450s catalyze an array of reactions including crosslinking of aromatic side
Chandrashekhar Padhi, Dinh T. Nguyen, Lingyang Zhu, Lide Cha, Jesse W. Wald, Douglas A. Mitchell, Wilfred A. van der Donk   +6 more
wiley   +2 more sources

Palaeoproteomic Deconvolution of Physical and Genetic Collagen Mixtures

Advanced Science, EarlyView.
ClassiCOL_v2 uses a novel “peptide patching” framework that treats any collagen sample as a patchwork of peptide sequences derived from phylogenetically related species. This allows the algorithm to simultaneously resolve two previously intractable problems: multi‐species samples and/or database deficiencies.
Ian Engels, Tristan Dedrie, Synnøve K. Mo, Simon Van de Vyver, Thijs R. A. Vandenbroucke, Kévin Di Modíca, Jan Decher, Alice Toso, Dieter Deforce, Simon Daled, Alexandra Burnett, Grégory Abrams, Maarten Dhaenens   +12 more
wiley   +1 more source

Metal–Metal Cooperative C─F and S─F Bond Cleavage by Low‐Valent Tetracobalt Clusters and Water‐Assisted Fluoroarene Hydrodefluorination

Angewandte Chemie, EarlyView.
Self‐assembled tetrahedral CoI4 clusters supported by simple bipyridine‐based ligands undergo core rearrangement to cleave S─F and C(sp2)─F bond, forming fluoride‐bridged tetracobalt(II)‐oxo clusters, while exposure of cobalt(I) clusters to molecular oxygen yields cubane‐type cobalt(III) oxo clusters.
Hoan M. Dinh, Pavan K. Vardhanapu, Robert R. Fayzullin, Eugene Khaskin, Julia R. Khusnutdinova   +4 more
wiley   +2 more sources

Use of Maldi-Tof MS biosensor in microbial assessment of Brazilian kefir grains

Revista Ceres
The aim of this study was to evaluate the use of Maldi-Tof MS biosensor in microbial assessment of Brazilian kefir grains. Maldi-Tof MS is a new methodology for the rapid diagnosis of microorganisms.
Roberta Oliveira Viana, Karina Teixeira Magalhães-Guedes, Disney Ribeiro Dias, Rosane Freitas Schwan   +3 more
doaj   +1 more source

MALDI-TOF mass spectroscopy of yeasts and filamentous fungi for research and diagnostics in the agricultural value chain

Chemical and Biological Technologies in Agriculture, 2017
Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS; MALDI biotyping) has become a standard tool for the accurate, rapid, and economical identification of pathogens in the clinical diagnostics laboratory. The method
David Drissner, Florian M. Freimoser
doaj   +1 more source

Controlling Self‐Doping in Conjugated Polyelectrolyte Copolymers to Vary the Threshold Voltage in OECTs

Advanced Electronic Materials, EarlyView.
Two series of self‐doped conjugated polyelectrolytes are synthesized from a non‐self‐dopable building block 3MEEET and a self‐dopable building‐block 3HOT−[TMA+] or 3HOT−[SO3H] enabling precise control over the degree of self‐doping, which in turn directly governs the threshold voltage (VT) in OECTs over a wide range of 700 mV.
Julian Hungenberg, Andreas W. Erhardt, Adrian Hochgesang, John Mohanraj, Lys Sprenger, Sahar Salehi, Christopher R. McNeill, Mukundan Thelakkat   +7 more
wiley   +1 more source

Typing of clinical and reference strains of Saccharomyces cerevisiae using pulsed-field gel electrophoresis and MALDI-TOF MS

Scientific Reports
In recent years matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has emerged as a rapid and reliable tool for microbial identification and diagnosis. However, its use for molecular typing of S.
Justyna Cieślik, Zofia Bakuła, Katarzyna Roeske, Aleksandra Kuryłek, Alicja Okrasińska, Jacek Bielecki, Marta Wróblewska, Tomasz Jagielski   +7 more
doaj   +1 more source

Rapid detection of porins by matrix-assisted laser desorption/ionization-time of flight mass spectrometry

Frontiers in Microbiology, 2015
The rapid and cost-efficient determination of carbapenem resistance is an important prerequisite for the choice of an adequate antibiotic therapy. A MALDI-TOF MS-based assay was set up to detect porins in the current study.
Yanyan eHU, Jia-chang eCai, Hong-wei eZhou, Rong eZhang, Gong-Xiang eChen   +4 more
doaj   +1 more source

Backbone Engineering of Benzodifurandione‐Based n‐Type OMIECs With Antiambipolar Behavior

Advanced Electronic Materials, EarlyView.
Two novel n‐type polymeric organic mixed ionic‐electronic conductors based on an azaisatin and benzodifurandione backbone are developed to enhance aqueous electrochemical devices. This backbone modification provides organic electrochemical transistors with high ambient stability, low threshold voltages, and tunable antiambipolar behavior, opening new ...
Dilara Gunturkun, Dilara Meli, Meike Kuhn, Eva M. Herzig, Jonathan Rivnay, Christian B. Nielsen   +5 more
wiley   +1 more source