Results 71 to 80 of about 213,931 (342)

Site-selective protein modification via disulfide rebridging for fast tetrazine/trans-cyclooctene bioconjugation [PDF]

, 2020
An inverse electron demand Diels–Alder reaction between tetrazine and trans-cyclooctene (TCO) holds great promise for protein modification and manipulation.
Chudasama, V., Kuan, S., Nogueira, J., Raabe, M., Weil, T., Xu, L., Zegota, M.   +6 more
core   +1 more source

The Uppsala APP Mutation Promotes Wild‐Type Amyloid‐β Aggregation and Deposition In Vivo

Advanced Science, EarlyView.
We investigated in vivo cross‐seeding of amyloid‐β (Aβ) isoforms in transgenic mice co‐expressing wild‐typeAβ and the Uppsala‐mutant Aβ variant (AβUpp), lacking six central residues. Weleveraged MALDI‐MS imaging and hyperspectral microscopy to follow spatio‐temporalAβ deposition.
Junyue Ge, María Pagnon de la Vega, Silvia Zampar, Enrica Cerilli, Srinivas Koutarapu, Ling Wu, Paul Fraser, Sertan Arkan, Vilmantas Giedraitis, Lars Lannfelt, Greta Hultqvist, Stina Syvänen, Martin Ingelsson, Jörg Hanrieder, Dag Sehlin   +14 more
wiley   +1 more source

Facile Preparation of a Poly[2]Catenane Network Using Self‐Assembled [2]Catenane Unit

Angewandte Chemie, EarlyView.
Polycatenanes show a higher degree of conformational freedom and mobility compared to covalent polymers. However, the number of its studies is far lower than that of other dynamic polymers. This may reflect the fact that the preparation of polycatenanes involves the complicated synthesis of covalent catenation.
Jinsa Li, Rui Hu, Yuxin Fu, Xiaohe Zhou, Jonathan L. Sessler, Xiaofan Ji   +5 more
wiley   +2 more sources

Identification of ticks from North of Italy by MALDI-TOF MS

Ticks and Tick-Borne Diseases
Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) has recently emerged as a promising method for arthropods identification. A total of 125 ticks collected from 2013 until 2023 in Italy either stored frozen at –20
Maria Sampieri, Adama Zan Diarra, Lionel Almeras, Annalisa Grisendi, Mara Scremin, Giulia Maioli, Philippe Parola   +6 more
doaj   +1 more source

Microéconométrie de la santé : remarques sur l'expérience française [PDF]

, 2000
Cet article analyse l'expérience française en microéconométrie de la santé à partir de quatre thèmes: le rôle de l'aléa moral dans la consommation de soins, la demande induite, la taille optimale des hôpitaux et l'effet potentiel d'une tarification par ...
Dormont, Brigitte
core   +1 more source

MALDI-TOF MS analysis of plant proanthocyanidins

Journal of Pharmaceutical and Biomedical Analysis, 2010
Proanthocyanidins or condensed tannins are among the most abundant polyphenols compounds in our diet and may play a key role in the prevention of cardiovascular and neurodegenerative diseases and cancer. These antioxidants are widely distributed in the plant kingdom both in food plants and in non-food plants.
Monagas Juan, María Josefina, Quintanilla-López, Jesús Eduardo, Gómez-Cordovés, Carmen, Bartolomé, Begoña, Lebrón-Aguilar, Rosa   +4 more
openaire   +3 more sources

A Cationic Supramolecule With Potent Antifungal Activity, Single‐Species Selectivity, and Strong Synergy With Echinocandins

Advanced Science, EarlyView.
We introduce a new membrane‐active antifungal design, Gua‐SMACS‐16, that exhibits high potency and single‐species selectivity for C. tropicalis while sparing other close species in the Candida genus. Moreover, when combining with caspofungin, a clinical antifungal drug inhibiting 1,3‐β‐glucan synthase, they exhibit ultra‐strong synergy across a panel ...
Tianjiao Dai, Adrielle Xianwen Chen, Eve Wai Ling Chow, Li Mei Pang, Jianguo Li, Chandra Shekhar Verma, Stefan H. Oehlers, Yue Wang, Ning Li   +8 more
wiley   +1 more source

A Nonbenzenoid Nanographene Horse Saddle With Four Pentagon–Octagon Pairs

Angewandte Chemie, EarlyView.
Horse‐saddle molecule: We report herein the design and synthesis of an unprecedented saddle‐shaped non‐benzenoid Nanographene featuring a fused four‐pair pentagon–octagon core. The horse‐saddle structure of HN1 is determined by single‐crystal X‐ray diffraction.
Qiang Huang, Yubin Fu, Zongbao Zhang, Jinjin Ding, Mengyuan Yu, Xinyang Ge, Boris Borrisov, Hartmut Komber, Zhen‐Lin Qiu, Yana Vaynzof, Ji Ma, Xinliang Feng   +11 more
wiley   +2 more sources

Limitations of MALDI-TOF MS in the fungal identification: could LC-MS/MS be a solution? [PDF]

, 2016
Fungal polyphasic identification aims the integration of different taxonomic characters. By using numerous techniques, it is assumed the level of variation in the technique can be reduced, although variation in the fungal specimen remains.
Godoy, Patricio, Lima, Nelson, Santos, Cledir   +2 more
core  

Review of the impact of MALDI-TOF MS in public health and hospital hygiene, 2018

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2019
Introduction MALDI-TOF MS represents a new technological era for microbiology laboratories. Improved sample processing and expanded databases have facilitated rapid and direct identification of microorganisms from some clinical samples.
B. Rodríguez-Sánchez, E. Cercenado, A. Coste, G. Greub   +3 more
semanticscholar   +1 more source