Results 81 to 90 of about 2,904 (195)

Inhibition of Jak/STAT signaling reduces the activation of pancreatic stellate cells in vitro and limits caerulein-induced chronic pancreatitis in vivo

Scientific Reports, 2017
Chronic pancreatitis (CP) is a fibro-inflammatory disease leading to pain, maldigestion, and pancreatic insufficiency. No therapeutic options exist due to a limited understanding of the biology of CP pathology.
Hannah M. Komar, Gregory Serpa, Claire Kerscher, Erin Schwoegl, Thomas A. Mace, Ming Jin, Ming-Chen Yang, Ching-Shih Chen, Mark Bloomston, Michael C. Ostrowski, Phil A. Hart, Darwin L. Conwell, Gregory B. Lesinski   +12 more
doaj   +1 more source

Maldigestion associated with exocrine pancreatic insufficiency: implications of gastrointestinal physiology and properties of enzyme preparations for a cause-related and patient-tailored treatment

, 1995
Clinical conditions in which secondary maldigestion associated with exocrine pancreatic insufficiency occur include chronic pancreatitis, cystic fibrosis, pancreatic cancer, partial or total gastrectomy, and pancreatic resection.
Bruno, M. J., van Leeuwen, D. J., Haverkort, E. B., Tytgat, G. N.   +3 more
core  

Comparative Investigation of pH–Dependent Availability of Pancreatic Enzyme Preparations In Vitro

Pharmaceuticals
This study aimed to compare different pancreatic enzyme preparations (PEPs) available in Germany regarding particle geometry and size, and to evaluate enzyme activity under physiologically relevant conditions in vitro.
Amy Todd, Emma Bennett-Huntley, Jonas Rosendahl, Jürgen Schnekenburger, Waldemar Uhl   +4 more
doaj   +1 more source

Celiac disease

Orphanet Journal of Rare Diseases, 2006
Celiac disease is a chronic intestinal disease caused by intolerance to gluten. It is characterized by immune-mediated enteropathy, associated with maldigestion and malabsorption of most nutrients and vitamins.
Holtmeier Wolfgang, Caspary Wolfgang F
doaj   +1 more source

Micronutrientes en cirugía bariátrica Micronutrients in bariatric surgery

Nutrición Hospitalaria, 2012
La obesidad mórbida es una enfermedad crónica con prevalencia creciente y que asocia una importante morbimortalidad. La cirugía bariátrica es el tratamiento más eficaz para conseguir una reducción ponderal mantenida en el tiempo y una disminución en las ...
M.ª J. Amaya García, F. J. Vilchez López, C. Campos Martín, P. Sánchez Vera, J. L. Pereira Cunill   +4 more
doaj  

Double-balloon jejunal perfusion to compare absorption of vitamin E and vitamin E acetate in healthy volunteers under maldigestion conditions

BACKGROUND/OBJECTIVES: The vitamin E derivative, alpha-tocopheryl acetate, is often included in formulations used in enteral nutrition. In this respect, we compared alpha-tocopherol and alpha-tocopheryl acetate absorption under 'maldigestion' conditions,
Redeuil, K., Nagy, K., Sagalowicz, L., Lobo, B., Braga-Lagache, S., Acquistapache, S., Moulin, J., Ramos, L., Holst, B., Kussmann, M., Courtet-Compondu, M-C, Santos, J., Beaumont, M., Williamson, G., Malagelada, J-R, Azpiroz, F.   +15 more
core   +1 more source

A behavioral intervention among early adolescents improves bone mass; however, lactose maldigestion is still a barrier

, 2012
A targeted behavioral intervention to improve calcium intake and bone mass was conducted at middle schools in 5 states. The primary outcomes of bone mass and dietary calcium were assessed among Asian, Hispanic, or non-Hispanic white girls between 10 -13 ...
Lee, Yu jin
core   +1 more source

Induction of artificial fat maldigestion by tetrahydrolipstatin assessed by the (13)C-hiolein breath test in healthy volunteers. A double-blind controlled pilot study.

, 2000
BACKGROUND (13)C-hiolein is a purified algal triglyceride which is synthesized with 98% of all carbon atoms of the molecule uniformly (13)C-labeled.
Meier R, Ashraf H, Hildebrand P, Beglinger C, Gyr N   +4 more
core   +1 more source

Symptoms, burden, and unmet needs of patients living with exocrine pancreatic insufficiency: a narrative review of the patient experience

BMC Gastroenterology
Exocrine pancreatic insufficiency (EPI) stems from a deficiency of functional pancreatic enzymes with consequent maldigestion and malnutrition. EPI shares clinical symptoms and manifestations with other disorders and is a considerable burden to ...
Jodie A. Barkin, Trudi B. Delk, Valerie J. Powell   +2 more
doaj   +1 more source

Characterization of a PNLIP variant identified in Amish pediatric patients with congenital pancreatic lipase deficiency

Journal of Lipid Research
Congenital pancreatic lipase deficiency (CPLD, OMIM #614338) is a rare exocrine pancreatic disorder presenting in late infancy with steatorrhea, fat-soluble vitamin deficiency, and low pancreatic lipase activity.
Grace E. Curry, Nicole L. Bertsch, Tran Quach, Rhonda Anderson, Neel Matiwala, Karlla W. Brigatti, Steven J. Wilhelm, Katie B. Williams, Mark E. Lowe, Zineb Ammous, Xunjun K. Xiao   +10 more
doaj   +1 more source