Genetic Modifiers of Parkinson's Disease: A Case–Control Study
ABSTRACT Objective To examine the associations of LRRK2 p.G2019S, GBA1 p.N409S, polygenic risk scores (PRS), and APOE E4 on PD penetrance, risk, and symptoms. Methods We conducted a US‐based observational case–control study using data from the 23andMe Inc. and Fox Insight Genetic Substudy (FIGS) databases.
Matthew J. Kmiecik +15 more
wiley +1 more source
Zika virus outbreak are on the rise in India: Clinical features, complications and prevention
Aminath Waafira +5 more
doaj +1 more source
Exposure to Rivals Does Not Affect Male Mate Choice in <i>Drosophila melanogaster</i>. [PDF]
Shankar H +9 more
europepmc +1 more source
Plasma Glial Fibrillary Acidic Protein Correlates With Brain Metal Burden in Wilson's Disease
ABSTRACT Objective Neuroinflammation driven by extracellular copper contributes to neuronal damage in Wilson's disease (WD). This study investigated the relationship between brain metal burden and peripheral neuroinflammation markers in WD. Methods We conducted a cross‐sectional study involving 89 participants, including patients with WD (n = 63 ...
Sung‐Pin Fan +12 more
wiley +1 more source
Estrogen Receptor Regulates Male Satellite Cells in a Female, but Not Male, Environment. [PDF]
Shams AS +4 more
europepmc +1 more source
Assessing a Mitochondrial Disease Treatment via a Novel Statistical Technique for Accelerometer Data
ABSTRACT Objective Therapeutic development for mitochondrial diseases, rare genetic disorders with pathogenic defects of oxidative phosphorylation, is hindered by unsatisfactory outcome measures. To address this problem, we provide the first clinical application of a novel, bias‐adjusted outcome measure of acceleration across a range of subjects ...
Ian W. McKeague +8 more
wiley +1 more source
Regional Geographic Dynamics of Male Midwifery Practice: An Exploratory Study of the Perspectives of the Male Midwife in Ghana's Volta and Northern Regions. [PDF]
Adu DBB, Ani-Amponsah M, Annan E.
europepmc +1 more source
ABSTRACT Background Olfactory dysfunction is frequently observed in patients with multiple sclerosis (MS); however, its underlying mechanisms remain poorly understood. To date, no studies have directly examined the nasal mucosal microbiota in MS. This study aimed to explore potential relationships among olfactory function, nasal microbiota composition,
Zidan Gao +5 more
wiley +1 more source
Working in pairs: male-female village health volunteers supporting maternal health and community engagement in remote and ethnic communities of Lao PDR-a qualitative study. [PDF]
Uehara M +5 more
europepmc +1 more source
Biochemical adaptation as a response to exercise. 1. Effect of swimming on the levels of lactic dehydrogenase, malic dehydrogenase and phosphorylase in muscles of 8-, 11- and 15-week-old rats [PDF]
Michael Gould, W. A. Rawlinson
openalex +1 more source

