Results 51 to 60 of about 12,815,066 (390)
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
BMC Urology, 2019 Background Human sperm cryopreservation is a simple and effective approach for male fertility preservation. Methods To identify potential proteomic changes in this process, data-independent acquisition (DIA), a technology with high quantitative accuracy ...
Longlong Fu +11 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley +1 more source
Recent advances in understanding and managing male infertility
F1000Research, 2019 Infertility is a prevalent condition affecting an estimated 70 million people globally. The World Health Organization estimates that 9% of couples worldwide struggle with fertility issues and that male factor contributes to 50% of the issues.
J. Fainberg, J. Kashanian
semanticscholar +1 more source
Leadership in multi-academy trusts [PDF]
, 2017 There has been an accelerating policy shift in England towards a system led improvement process for compulsory education, based on the principle of schools having greater autonomy.
Male, T
core
A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, EarlyView.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source
Idiopathic calcinosis of scrotum: A case report and review of the literature
Heliyon, 2022 We report a case of 57-year-old male patient with extensive scrotal idiopathic calcium salt deposits with multiple masses fused into a mass occupying 2/3 of the scrotal area.
Lin Feng +6 more
doaj +1 more source
Headship or System Leadership – Which Way to the Future? [PDF]
, 2007 Headship in English maintained schools is an occupation that is proving less than attractive for the vast majority of potential applicants, leading to the probability of a recruitment crisis in the near future.
Male, T
core
Auto-spermatophore extrusion in male crickets [PDF]
, 2003 The reproductive cycle of the male cricket consists of the mating stage and the sexually refractory stage. The latter is further divided into the first refractory stage (RS1) from spermatophore extrusion in copulation to spermatophore preparation after ...
Kumashiro, Mikihiko +2 more
core +1 more source