Results 61 to 70 of about 12,815,066 (390)

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

Obesity impairs male fertility through long-term effects on spermatogenesis

open access: yesBMC Urology, 2018
Objective This study aimed to investigate the effect and possible underlying mechanisms of high-fat diet-induced obesity on spermatogenesis in male rats. Methods A total of 45 male rats were randomly divided into control (n = 15, normal diet) and obesity
Yan-Fei Jia   +9 more
doaj   +1 more source

Measuring Reactive Oxygen Species in Semen for Male Preconception Care: A Scientist Perspective

open access: yesAntioxidants, 2022
Oxidative stress and elevated levels of seminal and sperm reactive oxygen species (ROS) may contribute to up to 80% of male infertility diagnosis, with sperm ROS concentrations at fertilization important in the development of a healthy fetus and child ...
Patience E. Castleton   +3 more
doaj   +1 more source

Reactive oxygen species and male reproductive hormones

open access: yesReproductive Biology and Endocrinology, 2018
Reports of the increasing incidence of male infertility paired with decreasing semen quality have triggered studies on the effects of lifestyle and environmental factors on the male reproductive potential.
M. Darbandi   +6 more
semanticscholar   +1 more source

Male great tits eavesdrop on simulated male–to–male vocal interactions [PDF]

open access: yesProceedings of the Royal Society of London. Series B: Biological Sciences, 2001
Animal communication generally occurs in the environment of a network of several potential signallers and receivers. Within a network environment, it is possible to gain relative information about conspecifics by eavesdropping on signalling interactions.
Peake, T.M.   +3 more
openaire   +3 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Kigezi local otter trap [PDF]

open access: yes, 1970
The otter belongs to the family Muslelidae of the super family Canoidea. It is a mammal related to the stoat, skunk, marten and wolverine. Its habitat is the water, and it is carnivorous in diet, feeding on fish and other water animals.
Male, M.M.
core  

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

open access: yesMolecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh   +8 more
wiley   +1 more source

Effects of Qilin pills on spermatogenesis, reproductive hormones, oxidative stress, and the TSSK2 gene in a rat model of oligoasthenospermia

open access: yesBMC Complementary Medicine and Therapies, 2020
s Background Qilin pills (QLPs), a classic Traditional Chinese Medicine (TCM) formula for treating male infertility, effectively improve semen quality in clinical trials.
Kaishu Zhang   +10 more
doaj   +1 more source

A missense variant in NCF1 is associated with susceptibility to unexplained recurrent spontaneous abortion

open access: yesOpen Life Sciences, 2022
Unexplained recurrent spontaneous abortion (URSA) is a major concern in reproductive medicine. Neutrophil cytosolic factor 1 (NCF1) polymorphisms leading to low production of reactive oxygen species (ROS) are strongly associated with autoimmune diseases.
Du Mengxuan   +9 more
doaj   +1 more source

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