Results 61 to 70 of about 12,519,177 (391)

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

The Private Lands Opportunity: The Case for Conservation Incentives [PDF]

open access: yes, 2003
Outlines a number of opportunities available for enlisting the participation of landowners as partners in conservation as part of an effort to meet the nation's conservation ...
Michael Bean   +3 more
core  

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu   +11 more
wiley   +1 more source

The Professional Induction of Headteachers in England: Findings from the IBPS project [PDF]

open access: yes, 2001
This paper reports on the data gathered through a self-completion questionnaire administered to a sample of headteachers in England who took up post in September, 2000.
Male, T
core  

Obesity impairs male fertility through long-term effects on spermatogenesis

open access: yesBMC Urology, 2018
Objective This study aimed to investigate the effect and possible underlying mechanisms of high-fat diet-induced obesity on spermatogenesis in male rats. Methods A total of 45 male rats were randomly divided into control (n = 15, normal diet) and obesity
Yan-Fei Jia   +9 more
doaj   +1 more source

Recent advances in understanding and managing male infertility

open access: yesF1000Research, 2019
Infertility is a prevalent condition affecting an estimated 70 million people globally. The World Health Organization estimates that 9% of couples worldwide struggle with fertility issues and that male factor contributes to 50% of the issues.
J. Fainberg, J. Kashanian
semanticscholar   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

The Impact of National Culture on School Leadership in England [PDF]

open access: yes, 1998
This paper reports on the survey findings of an international project to examine the impact of national culture on school leadership. The survey instrument was based on the work of Geert Hofstede, with the data collected for this paper emerging from semi-
Male, T
core  

The impact on a primary school community in England of failed inspection and subsequent academisation [PDF]

open access: yes, 2015
© 2015 Taylor & Francis. This research reports upon the impact of two concurrent processes of Special Measures and academisation applied to a primary school in the north of England as a result of an unsatisfactory inspection by the Office for Standards ...
Elton, J, Male, T
core   +1 more source

Magnetic perforation: Why we say NO to kids

open access: yesJournal of Pediatric Surgery Case Reports, 2023
Foreign body (FB) ingestion is common among children. It is alarming when it is a magnetic foreign body as it can cause interloop attraction resulting in perforation, fistulas and or volvulus.
Aishath Azna Ali   +9 more
doaj  

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