Results 91 to 100 of about 107,483 (325)

Family Structure and Reproductive Health Decision Making among the Ogu of Southwestern Nigeria: A Qualitative Study [PDF]

, 2003
This study examines the structure of the Ogu family and its influence on reproductive health decision-making using a qualitative approach. Data were sourced through nine focus groups organized in the study area among married men and women.
Isiugo-Abanihe, U. C., Wusu, O.
core   +1 more source

Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira, David Agorku, Andre Rosa, Julia Roosz, Lena Christ, Nicole Anderle, Ajinkya Kulkarni, Abir Hussein, Sana S. Sayedipour, Omar F. Luna, Tobias Legler, Philipp Ströbel, Fernando Albericio, Luis Cruz, Phillipp Beckhove, Peter Loskill, Frauke Alves, M. Andrea Markus, Fernanda Ramos‐Gomes   +18 more
wiley   +1 more source

Family planning attitude and practice amongst male doctors in Enugu, Eastern Nigeria

International Journal of Medicine and Health Development, 2002
Objective: To determine the disposition of medical personnel to contraception in Enugu, Eastern Nigeria. Methods: A questionnaire survey of the contraceptive attitude and practice of 386 male doctors practicing in Enugu and a comparison of these with ...
H E Onah, H U Ezegwui
doaj  

Reversible Contraceptive Potential of FDA Approved Excipient N, N-Dimethylacetamide in Male Rats

Frontiers in Physiology, 2020
Development of an effective male contraceptive agent remains a challenge. The present study evaluates the potential of N, N-Dimethylacetamide (DMA), a FDA approved excipient as a male contraceptive agent.
Nupur Khera, Nupur Khera, Chafik Ghayor, Anna K. Lindholm, Ekaterina Pavlova, Nina Atanassova, Franz E. Weber, Franz E. Weber, Franz E. Weber   +8 more
doaj   +1 more source

Male Partners Involvement in Spousal Contraceptive Use: A Perspective of a Contemporary African Setting [PDF]

, 2018
Background: Contraceptive use by women is one of the tools used for promoting family health and slowing population growth. Evidence has suggested that contraceptive use in Nigeria is below acceptable levels in spite of the fact that family planning ...
Afolaranmi, T. O. (Tolulope), Azuike, M. J. (Mackpherson), Chirdan, O. O. (Oluwabunmi), Hassan, Z. I. (Zuwaira), Misak, K. A. (Ketura), Omofolarin, O. S. (Olusoji)   +5 more
core  

Endothelial Cell‐Specific Molecule‐1 (ESM1): An Endogenous Anticoagulant and Protective Factor in Venous Thrombosis

Advanced Science, EarlyView.
This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen, Xiaojuan Ge, Dongxu Fu, Haijun Mei, Feng Lv, Chao Yang, Jiahao Lu, Xiaozhong Shen, Bowen Li, Xiaoning Wang, Dong Liu   +10 more
wiley   +1 more source

Contraceptive confidence and timing of first birth in Moldova: an event history analysis of retrospective data [PDF]

, 2014
Objectives: To test the contraceptive confidence hypothesis in a modern context. The hypothesis is that women using effective or modern contraceptive methods have increased contraceptive confidence and hence a shorter interval between marriage and first ...
Durrant, Gabriele B., Lyons-Amos, Mark, Padmadas, Sabu S.   +2 more
core   +2 more sources

Nanoparticle Immunoadjuvant Complexes Augment Germinal Center Responses to Vaccination

Advanced Science, EarlyView.
Scaffolding IL‐21 on the surface of a self‐assembling nanoparticle immunogen drives improved germinal center and humoral immune responses. These nanoparticle immunoadjuvant complexes (NICs) functionally modulate the germinal center driving improved somatic hypermutation and antibody maturation, suggesting this platform has potential utility as a ...
Nicholas J. Tursi, Colby J. Agostino, Jinwei Huang, Toshitha Kannan, Niklas Laenger, Jennifer Londregan, Katlyn Lederer, Michaela Helble, Nicole Bedanova, Cory Livingston, Ebony N. Gary, Madison McCanna, Marta Tarquis Medina, Rumi Habib, Ignacio Rodriguez Relaño, Ivan Maillard, Ami Patel, David Allman, Andrew Kossenkov, Amelia Escolano, Daniel W. Kulp, David. B. Weiner   +21 more
wiley   +1 more source

A Simplified Three‐Tailed N‐Alkyl Phosphoramidate Lipid Platform Enables Inguinal Adipose‐Accumulated mRNA Delivery for Anti‐Obesity Therapy

Advanced Science, EarlyView.
This study develops an mRNA therapy encoding a long‐acting GLP‐1/FGF21 fusion protein. A three‐tailed ionizable lipid engineered three‐component lipid nanoparticle delivers the mRNA to inguinal adipose tissue. In obese mice, this targeted, dual‐hormone treatment potently reduces body weight, fat mass, presenting a localized strategy for metabolic ...
Bin Ma, Yunxuan Liu, Huijuan Zhang, Yian Fang, Yizhe Xue, Junsheng Xue, Ziqiong Jiang, Tianyan Zhou, Yanyun Hao, Fei Xie, Lei Miao   +10 more
wiley   +1 more source

Advances in Male Contraception: When Will the Novel Male Contraception be Available?

The World Journal of Men's Health
Many contraceptive methods have been developed over the years due to high demand. However, female contraceptive pills and devices do not work for all females due to health conditions and side effects.
Jongwon Kim, Byeongchan So, Yongki Heo, Hongyun So, Jung Ki Jo   +4 more
doaj   +1 more source