Results 11 to 20 of about 105,857 (310)

Tex13a Optimizes Sperm Motility via Its Potential Roles in mRNA Turnover

open access: yesFrontiers in Cell and Developmental Biology, 2021
mRNAs have been found to undergo substantial selective degradation during the late stages of spermiogenesis. However, the mechanisms regulating this biological process are unknown. In this report, we have identified Tex13a, a spermatid-specific gene that
Yinchuan Li   +10 more
doaj   +1 more source

High Throughput scRNA-Seq Provides Insights Into Leydig Cell Senescence Induced by Experimental Autoimmune Orchitis: A Prominent Role of Interstitial Fibrosis and Complement Activation

open access: yesFrontiers in Immunology, 2022
Leydig cells (Lc), located in the interstitial space of the testis between seminiferous tubules, produce 95% of testosterone in male individuals, which is pivotal for male sexual differentiation, spermatogenesis, and maintenance of the male secondary sex
Yinchuan Li   +10 more
doaj   +1 more source

Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential

open access: yesFrontiers in Physiology, 2022
In mammalian cells, 10 different adenylyl cyclases produce the ubiquitous second messenger, cyclic adenosine monophosphate (cAMP). Amongst these cAMP-generating enzymes, bicarbonate (HCO3−)-regulated soluble adenylyl cyclase (sAC; ADCY10) is uniquely ...
Thomas Rossetti   +8 more
doaj   +1 more source

Ethnomedicine Study on Justicia gendarussa for Male Contraception at the Nimboran Ethnic, Jayapura

open access: yesJurnal Farmasi dan Ilmu Kefarmasian Indonesia, 2022
Background: Justicia gendarussa from Papua has traditionally been used for the treatment of several diseases, and phytochemical studies have been carried out since 1987.
Niluh Indrawati   +3 more
doaj   +1 more source

Willingness to use novel reversible methods of male birth control: a community-based survey of cisgender men in the United States

open access: yesContraception and Reproductive Medicine, 2023
Background There is high global demand for new methods of male birth control (MBC). However, contemporary evidence regarding men’s method-specific attitudes and their determinants is sparse.
Summer L. Martins, Christy M. Boraas
doaj   +1 more source

High-throughput screening method for discovering CatSper inhibitors using membrane depolarization caused by external calcium chelation and fluorescent cell barcoding

open access: yesFrontiers in Cell and Developmental Biology, 2023
The exclusive expression of CatSper in sperm and its critical role in sperm function makes this channel an attractive target for contraception. The strategy of blocking CatSper as a male, non-hormonal contraceptive has not been fully explored due to the ...
Guillermina M. Luque   +9 more
doaj   +1 more source

Advances in Male Contraception [PDF]

open access: yesEndocrine Reviews, 2008
Despite significant advances in contraceptive options for women over the last 50 yr, world population continues to grow rapidly. Scientists and activists alike point to the devastating environmental impacts that population pressures have caused, including global warming from the developed world and hunger and disease in less developed areas.
Stephanie T, Page   +2 more
openaire   +2 more sources

An examination of the barriers to and benefits from collaborative couple contraceptive use in Rwanda

open access: yesReproductive Health, 2021
Background Supportive male involvement is strongly correlated with contraceptive use. In Rwanda, where the contraceptive prevalence rate among married women increased from 17 to 52% from 2005 to 2010, and stagnated at 53% in 2015, understanding the role ...
Hilary Schwandt   +25 more
doaj   +1 more source

'If I have only two children and they die. who will take care of me?' : a qualitative study exploring knowledge, attitudes and practices about family planning among Mozambican female and male adults [PDF]

open access: yes, 2017
Background: By focusing upon family planning counselling services, the Mozambican government has significantly enhanced the general health of female and male clients.
Capurchande, Rehana   +3 more
core   +2 more sources

Male contraception [PDF]

open access: yesFertility and Sterility, 2016
AbstractApproximately 40 to 50% of pregnancies are unintended. Contraceptive use significantly reduces the risk of unintended pregnancy. Approximately 70% of couples' contraceptive use is female and 30% is male, attributable to the reliance on condoms and vasectomies.
openaire   +3 more sources

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