Results 71 to 80 of about 105,857 (310)

Polysaccharide Adjuvants as Innate Immune Trainers: Bridging Pattern Recognition Receptor (PRR) Activation and Metabolic Reprogramming for Synthetic Vaccine Design

open access: yesAdvanced Science, EarlyView.
Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Jeong Hyun Moon   +8 more
wiley   +1 more source

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

open access: yesAdvanced Science, EarlyView.
Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen   +8 more
wiley   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

open access: yesAdvanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang   +15 more
wiley   +1 more source

Family Planning Market in India [PDF]

open access: yes, 2017
This literature review captures existing knowledge across a range of products and players in India's family planning market. The product scope covers condoms, oral contraceptive pills, injectable contraceptives, intra-uterine devices, and male and female
Laura Amaya   +2 more
core  

Kontribusi Penggunaan Kontrasepsi Hormonal terhadap Perbedaan Prevalensi Hipertensi Perempuan dan Lelaki di Indonesia : Perspektif Jender Riskesdas 2013 [PDF]

open access: yes, 2016
Gender perspective has point of view that female and male share equal risk in health. In-equal health status between female and male is not only due to biological aspect, but also social construction, norms and role in the society.
Isfandari, S. (Siti)   +3 more
core   +2 more sources

Safety and Efficacy of Adoptive Transfer of Stem Cell Memory Enriched Virus Specific T Cells against CMV and EBV

open access: yesAdvanced Science, EarlyView.
This study finds that CD8⁺ TSCM cells exhibit superior self‐renewal, differentiation, and antiviral activity. Transcriptome and epigenome analyses highlight MAPK cascade regulation in TSCM cells. In vivo, virus‐specific TSCM cells show enhanced persistence and tumor protection.
Xun‐Hong Cao   +13 more
wiley   +1 more source

Antifertility effects of furazolidone in Adult male rats [PDF]

open access: yesJournal of Kerman University of Medical Sciences, 1999
Although various contraceptive methods and medications have been devised so far,there is no ideal male contraceptive agent,free from side effects and without adverse effects on secondary sexual  characterestics and sexual behaviour.in this study the ...
H.R Sadeghipour- Rodsari   +2 more
doaj  

Contraceptive Sabotage [PDF]

open access: yes, 2014
This Article responds to the alarm recently sounded by the American College of Obstetricians and Gynecologists over “birth control sabotage”—the “active interference [by one partner] with [the other] partner’s contraceptive methods in an attempt to ...
Plunkett, Leah A.
core   +1 more source

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

open access: yesAdvanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong   +6 more
wiley   +1 more source

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