Advanced Science, EarlyView.The authors engineer colorectal cancer cells with reduced redundancy of UHRF1 and DNMT1, key DNA methylation maintenance factors, lowering the maintenance threshold and sensitizing cells to inhibition. They develop reporter assays driven by endogenous tumor‐suppressor gene promoters with enhanced sensitivity and dynamic range to demethylating drugs ...
Cuicui Xia +15 more
wiley +1 more source
How women and providers perceive male partner resistance to contraceptives in Western Kenya: A qualitative study. [PDF]
Sex Reprod Healthc, 2021 Britton LE +5 more
europepmc +1 more source
PAF Triggered Pyroptotic NETosis Aggravates Myocardial Ischemia/Reperfusion Injury
Advanced Science, EarlyView.Platelet activating factor (PAF) secreted by cardiomyocytes during MI/R, drives NETs formation and subsequent NETosis. PAF/NETosis signaling activation is an initiative and causal factor in driving MI/R injury. This study identifies dapagliflozin as a potent NETosis inhibitor, and demonstrates that manipulating PAF‐NETosis signal by dapagliflozin or ...
Jiawei Wu +11 more
wiley +1 more source
Male Partner Involvement in Child Feeding and Associated Factors Among Children Aged 6 to 23 Months in Hawassa City, Sidama Region, Southern Ethiopia: A Community Based Cross Sectional Study. [PDF]
Food Sci NutrBolka A, Assaye M, Phliphos A.
europepmc +1 more source
The Impact of Male Partner Circumcision on Women's Health Outcomes. [PDF]
AIDS Educ Prev, 2020 Moodley J +4 more
europepmc +1 more source
Male partner participation in maternity care and social support for childbearing women: a discussion paper. [PDF]
Philos Trans R Soc Lond B Biol Sci, 2021 Daniele MAS.
europepmc +1 more source
Advanced Science, EarlyView.TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng +9 more
wiley +1 more source
Ring-ing in the Future: Participant and Male Partner Perspectives Regarding Future Use of the Dapivirine Vaginal Ring for HIV Prevention. [PDF]
AIDS Behav, 2022 Reddy K +13 more
europepmc +1 more source
Advanced Science, EarlyView.Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng +14 more
wiley +1 more source
'I am a father but not pregnant': a qualitative analysis of the perspectives of pregnant couples on male partner role during pregnancy care in Bamenda, Cameroon. [PDF]
Reprod HealthFoglabenchi LH, Stöckl H, Marchant T.
europepmc +1 more source