Results 241 to 250 of about 451,113 (281)

Deciphering the Impact of RAC1‐SPTAN1 in ARPKD Cystogenesis Using Multifaceted Models

Advanced Science, EarlyView.
Distal/connecting tubules expressing SLC8A1 have been suggested as a potential origin of ARPKD cysts. SPTAN1 has been identified as a key molecule in ARPKD cyst formation. Restoring SPTAN1 in PKHD1−/− organoids reduced cyst formation, normalized calcium levels, and decreased RAC1/c‐FOS expression, highlighting SPTAN1's role in ARPKD and the potential ...
Shohei Kuraoka, Yuhei Higashi, Suguru Saito, Solmaz Pourgonabadi, Honami Honjoh, Sho Ishigaki, Peter C. Harris, Lisa M. Satlin, Michifumi Yamashita, Ryuji Morizane   +9 more
wiley   +1 more source

Endometrial Epithelial Lactate Deficiency Drives CD8+ T‐Cells Dysregulation in Unexplained Recurrent Implantation Failure

Advanced Science, EarlyView.
Unexplained recurrent implantation failure (RIF) represents a significant clinical challenge. Our results demonstrate that reduced lactate production in the RIF endometrium impairs the suppression of cytotoxic CD8+ T‑cells, allowing their proliferation and thereby disrupting the local immune balance essential for successful embryo implantation.
Yuanlin He, Kang Ke, Qingxia Meng, Yichun Guan, Jichun Tan, Hong Lv, Boxian Huang, Chan Tian, Qinyan Zou, Mingxing An, Yao Gao, Jingjing Chen, Xiaoyu Wei, Xi Wang, Hongxia Ma, Yuan Lin, Feiyang Diao, Yayun Gu, Zhibin Hu   +18 more
wiley   +1 more source

Wrinkle‐Adaptive Kirigami Wearables With Anisotropic Deformability for Sleep EEG Monitoring

Advanced Science, EarlyView.
This article introduces a wrinkle‐adaptive, kirigami‐structured wearable EEG patch that personalizes electrode‐skin conformity to stabilize the interface and enable wireless, high‐quality sleep monitoring. ABSTRACT Wearable electroencephalography (EEG) devices offer a promising solution for continuous brain monitoring outside laboratory settings ...
Jungmin Kim, Ka Ram Kim, Byeongjun Lee, Cheoljeong Park, Seong J. Cho, Woon‐Hong Yeo   +5 more
wiley   +1 more source

Trained Memory of Uterine Macrophages Improves Subsequent Pregnancy Outcomes

Advanced Science, EarlyView.
This study identifies that pregnancy imprints a durable, pregnancy‐specific form of trained immune memory in uterine macrophages, marked by the emergence of LILRB3+/PIR‐B+ cells that expand across gestations, acquire a tolerogenic and metabolically rewired phenotype, and actively protect against inflammatory pregnancy loss in mice.
Jing Wang, Ning Lu, Xin‐Xiu Lin, Xu‐Hui Fang, Yi‐Hui Li, Qing‐Peng Luo, Yu‐Ting Peng, Gil Mor, Ai‐Hua Liao   +8 more
wiley   +1 more source

SETD1A Regulates Glycolysis and Senescence of Nucleus Pulposus Cells via H3K4me3–HELZ2/PPARα‐HIF1α Axis to Drive Intervertebral Disc Degeneration

Advanced Science, EarlyView.
SETD1A is a key epigenetic regulator in NPCs during IDD. In normal NPCs, it sustains H3K4me3–HELZ2/PPARα–HIF1α signaling to maintain glycolytic energy metabolism and proliferation. In degenerated NPCs, reduced SETD1A disrupts this axis, impairing glycolysis and accelerating senescence, highlighting a promising therapeutic target for IDD.
Jiawei Fu, Xue Leng, Jiang Long, Zhengao Liao, Xiaoqin An, Xuezheng Ai, Dan Long, Changqing Li, Bo Huang, Yue Zhou, Shiwu Dong, Chencheng Feng   +11 more
wiley   +1 more source

Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell Ferroptosis Through GSK3β Dependent Ubiquitin‐Mediated NRF2 Degradation

Advanced Science, EarlyView.
Lipid metabolic stress triggers ferroptosis in PDLSCs through the GSK3β/NRF2 pathway, thereby aggravating periodontal bone loss. Upregulated GSK3β promotes NRF2 ubiquitination and proteasomal degradation via β‐TrCP, suppressing NRF2 nuclear translocation and antioxidant target expression.
Yuxiao Zhang, Xiangyao Wang, Yaxin Wu, Liping Liu, Gaoshaer Nuerlan, Ahsawle Ozathaley, Xiaorui Zhang, Jinping Wang, Bowen Yang, Jing Mao, Yan Liu, Shiqiang Gong   +11 more
wiley   +1 more source

Exploring the role of carers in psychiatric home treatment: qualitative multi-method study. [PDF]

BMC Psychiatry
Kula E, Salzmann M, Waldmann T, Nikolaidis K, Längle G, Brieger P, Timm J, Fischer L, Raschmann S, Holzke M, Rout S, Hirschmeier C, Hamann J, Herwig U, Baumgardt J, Kilian R, Weinmann S, Bechdolf A, von Peter S, Schwarz J.   +19 more
europepmc   +1 more source

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Male partner involvement in reducing loss to follow‐up after cervical cancer screening in Uganda

International Journal of Gynecology & Obstetrics, 2009
AbstractObjectiveTo evaluate the efficacy of male partner involvement in reducing loss to follow‐up among women in Uganda referred for colposcopy after a positive cervical cancer‐screening test.MethodsIn 2 family‐planning/postnatal clinics at Mulago Hospital, Kampala, Uganda, 5094 women were screened for cervical lesions.
Twaha, Mutyaba, Florence, Mirembe, Sven, Sandin, Elisabete, Weiderpass   +3 more
openaire   +4 more sources

Pregnancy and childbirth: male partner involvement in Uasin Gishu, Kenya

African Journal of Midwifery and Women's Health, 2022
IntroductionIn many African countries, pregnancy and childbirth has traditionally been regarded as a woman’s affair. As a result, male partner involvement and participation in pregnancy and childbirth has been minimal, which is thought to have contributed to the high rate of maternal and neonatal morbidities and mortalities. Male partners are often key
Kamau, Tabitha, Riang’a, Roselyter Monchari, Mwanzia, Lydia, Buluku, Elizabeth, Sawe, Caroline, Wambugu, Beth, Patel, Kirtika, Mutai, Judith, Jomo, Pauline Mwenje, Kemboi, Sharon, Talam, Patricia Chepchumba, Sang, Cindy   +11 more
openaire   +2 more sources

Male partners' involvement during antenatal care in Ekiti State, southwest Nigeria

African Journal of Midwifery and Women's Health, 2022
Background/Aims Male partners' involvement in the use of antenatal care services has been evaluated as a crucial determinant in the uptake of these services. This study investigated the opinion of antenatal care attendees on male partners' role in the use of antenatal care services in Ekiti State.
Idowu Pius Ade-Ojo, Olusanya Rufus Olofinbiyi, Benedict Tolulope Adeyanju, Adebola Ayotomiwa Olajuyin, Tajudeen Oluwaseun Yusuf   +4 more
openaire   +1 more source