Results 31 to 40 of about 4,248,796 (240)

UCtracker: A Deep Learning–Based DNA Methylation Model for Noninvasive Diagnosis and Recurrence Surveillance of Urothelial Carcinoma in a Prospective Study

Advanced Science, EarlyView.
We developed UCtracker, a urine DNA methylation–based deep learning model, for noninvasive diagnosis and postoperative surveillance of urothelial carcinoma. UCtracker demonstrates high diagnostic accuracy, robustness at ultralow sequencing depth, early recurrence detection, and dynamic risk‐stratified monitoring of molecular residual disease ...
Shengwei Xiong, Gaojie Li, Yucai Wu, Yuan Liang, Heng Guo, Yu Zhang, Gengyan Xiong, Long Tian, Xin Zhang, Ye Tian, Zhengguo Ji, Bin Guo, Yue Shi, Jian Fan, Zhihua Li, Yanqing Gong, Shiming He, Xuesong Li, Weimin Ci, Liqun Zhou   +19 more
wiley   +1 more source

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li, Yong Wei, Yongshan Li, Yuxiang Dong, Jiancheng Lv, Mingzhi Yuan, Ao Shen, Fuyang Liu, Yetao Zhang, Youjian Li, Ruixi Yu, Yang Liu, Tong Zhao, Jun Wang, Kai Zhou, Zongyao Fan, Manning Wang, Jun Xu, Mulong Du, Min Gu, Bing Yao, Qingyi Zhu   +21 more
wiley   +1 more source

Large verrucous penis cancer in a young patient in the Brazilian Amazon: Case report and discussion on the region's reality

Urology Case Reports, 2019
Introduction: Penile cancer is a rare malignant tumour top in urology, especially in developed countries or in a favourable cultural habit. However, in developing countries or with a low socio-economic population, the incidence increases considerably, as
Francisco Marcos da Silva Barroso, Cristiano Silveira Paiva, Flavio Antunes de Sousa, Gualter Ferreira de Andrade Júnior, Roger Arthur da Cunha Alves, Ketlen Gomes da Costa, Rafaelle Taynah Soares da Silva, Juan Eduardo Rios Rodriguez, Evandro Aulice de Peder Júnior   +8 more
doaj   +1 more source

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

Advanced Science, EarlyView.
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang, Shihui Lin, Tianyu Wu, Zhixin Zhang, Hong Zhou, Xue Hong, Youhua Liu   +6 more
wiley   +1 more source

Contemporary urologic minilaparoscopy: indications, techniques, and surgical outcomes in a multi-institutional European cohort [PDF]

, 2014
OBJECTIVES: To provide an analytical overview of contemporary indications, techniques, and outcomes of urologic minilaparoscopy (ML) in multiple European centers.
Damiano R, Porpiglia, F, Bertolo, R, Rassweiler, J, Bertolo, Riccardo, Gozen, AS, Greco, F, Autorino, Riccardo, Saita, Alberto, Saita, A, Gozen, Ali Serdar, Saita A, Falsaperla, Mario, Zacchero, Monica, Rassweiler, J., PAGLIARULO, VINCENZO, De Sio, Marco, Fiori, C, Porpiglia F, Terrone C, Rassweiler J., Autorino R, De Sio, M, Fiori, Cristian, Greco, Francesco, Breda, A, Cicione, Antonio, Porpiglia, Francesco, Celia, A, Autorino, R, Falsaperla, M, Pagliarulo V, Cicione A, Zacchero M, Celia A, Bertolo R, Volpe, Alessandro, Rassweiler, Jens, Cicione, A, Volpe A, Terrone, Carlo, De Sio M, Greco F, Lima, Estêvão Augusto Rodrigues de, Celia, Antonio, Gozen AS, Damiano, R, Terrone, C, Falsaperla M, Breda A, Lima, E, Fiori C, Damiano, Rocco, Volpe, A, Pagliarulo, V, Zacchero, M, Lima E, Breda, Alberto, Lima, Estevao   +58 more
core   +3 more sources

A Scoping Review of Emerging and Established Surgical Robotic Platforms With Applications in Urologic Surgery

, 2021
Objectives: Since the introduction of the first master–slave robotic platform for surgical procedures, there have been ongoing modifications and development of new platforms, but there is still a paucity of commercially available systems.
Maylynn Ding, Anil Kapoor, Jason Lee, Jason Y. Lee, Braden Millan, Shavy Nagpal   +5 more
core   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

A 10-Year Multicentre Experience of Australian Penile Fracture Repair Outcomes

Société Internationale d’Urologie Journal
Objectives and Methods: Penile fractures are a urologic emergency involving the rupture of the tunica albuginea of the corpora cavernosum. Geography is known to impact fracture aetiology, and higher impact aetiology is thought to predispose patients to ...
Matthew Yii, Chrisdan Gan, Kirby R. Qin, Damien Bolton, Gideon Blecher   +4 more
doaj   +1 more source

Enhancing surgical efficiency: predicting same-day cancellations in urologic procedures [PDF]

World Journal of Urology
Pablo Suarez, David Bayne
exaly   +2 more sources

Prognostic Impact of Circumferential Resection Margin in Minimally Invasive Surgery for Locally Advanced Rectal Cancer: A Multicenter Prospective Study

Annals of Gastroenterological Surgery, EarlyView.
This multicenter prospective study provides the first Japanese evidence that circumferential resection margin positivity after minimally invasive surgery is associated with poorer long‐term outcomes in locally advanced rectal cancer. As the cohort predominantly included patients treated with upfront surgery, these findings provide important evidence to
Atsushi Hamabe, Masaaki Ito, Shigeo Toda, Yusuke Suwa, Suguru Hasegawa, Masanori Kotake, Masafumi Inomata, Kazuki Ueda, Atsushi Ogura, Kiichi Sugimoto, Kei Kimura, Koki Otsuka, Tatsuki Noguchi, Koya Hida, Yasumitsu Hirano, Kazushige Kawai, Shigeru Yamagishi, Takeshi Naitoh, Ichiro Takemasa, on behalf of Japan Society of Laparoscopic Colorectal Surgery   +19 more
wiley   +1 more source