Cell Death and Disease, 2021 Abnormal expression of long-noncoding RNA is involved in the tumorigenesis and progression of various cancers, but the potential molecular regulatory mechanisms are unclear.
Mo Liu +14 more
doaj +1 more source
TCRP1 activated by mutant p53 promotes NSCLC proliferation via inhibiting FOXO3a
Oncogenesis, 2022 Previously, our lab explored that tongue cancer resistance-associated protein (TCRP1) plays a central role in cancer chemo-resistance and progression. Absolutely, TCRP1 was significantly increased in lung cancer. But the mechanism is far from elucidated.
Hao Liu +8 more
doaj +1 more source
Cell Communication and Signaling, 2022 Background Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer with poor prognosis and limited treatment. As a major component of the tumor microenvironment, tumor-associated macrophages (TAMs) play an important role in ...
Xiangzhou Chen +10 more
doaj +1 more source
Can malignant and inflammatory pleural effusions in dogs be distinguished using computed tomography [PDF]
, 2017 Computed tomography (CT) is the primary imaging modality used to investigate human patients with suspected malignant or inflammatory pleural effusion, but there is a lack of information about the clinical use of this test in dogs.
Aquino +35 more
core +1 more source
Cell Death Discovery, 2022 Activating mutations of epidermal growth factor receptor (EGFR) contributes to the progression of non-small cell lung cancer (NSCLC). EGFR tyrosine kinase inhibitor (TKI)-targeted therapy has become the standard treatment for NSCLC patients with EGFR ...
Jun Wang +10 more
doaj +1 more source
Mucoepidermoid carcinoma associated with osteosarcoma in a true malignant mixed tumor of the submandibular region [PDF]
, 2015 True malignant mixed tumor, also known as carcinosarcoma, is a rare tumor of the salivary gland composed of both malignant epithelial and malignant mesenchymal elements.
Cerbelli, B +4 more
core +3 more sources
Malignant melanoma of the urethra: a rare histologic subdivision of vulvar cancer with a poor prognosis [PDF]
, 2012 Malignant melanoma of the urethra is a rare tumour that is difficult to diagnose and treat, resulting in a poor prognosis. In this paper, we present the case of a 65-year-old woman who was referred to a gynaecologist because of a urethral mass that ...
Alkatout, Ibrahim +8 more
core +2 more sources
Impact of a digital manual for guidance on malignant hyperthermia: patient education
Orphanet Journal of Rare Diseases, 2022 Background Malignant hyperthermia (MH) is a rare, hereditary disease with a hypermetabolic response to volatile anesthetics/succinylcholine. Susceptible patients face difficulties due to a lack of knowledge about MH.
Gislene Rodrigues +4 more
doaj +1 more source
Frequency and significance of Ras, Tert promoter, and Braf mutations in cytologically indeterminate thyroid nodules: A monocentric case series at a tertiary-level Endocrinology unit [PDF]
, 2017 PurposeThe management of thyroid nodules of indeterminate cytology is controversial. Our study aimed to establish the frequency and significance of H-,K-,N-RAS, TERT promoter, and BRAF gene mutations in thyroid nodes of indeterminate cytology and to ...
Barollo, Susi +13 more
core +2 more sources
Bibliometric Analysis of Chimeric Antigen Receptor-Based Immunotherapy in Cancers From 2001 to 2021
Frontiers in Immunology, 2022 BackgroundChimeric antigen receptor (CAR)-based immunotherapy has shown great potential for the treatment of both hematopoietic malignancies and solid tumors.
Zhanpeng Ou +16 more
doaj +1 more source