The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity
FEBS Open Bio, EarlyView.We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda +9 more
wiley +1 more source
Integrative molecular subtypes of acute myeloid leukemia
Blood Cancer Journal, 2023 Qianxing Mo +7 more
doaj +1 more source
Multiple malignant neoplasms in the air and upper food passages [PDF]
, 1958 Samuel S. Epstein, H. J. Shaw
openalex +1 more source
Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo
FEBS Open Bio, EarlyView.The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu +12 more
wiley +1 more source
The Effect of Hexamethonium upon Cerebral Blood Flow and Metabolism in Patients with Premalignant and Malignant Hypertension [PDF]
, 1955 Charles W. Crumpton +4 more
openalex +1 more source
High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer
FEBS Open Bio, EarlyView.Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson +5 more
wiley +1 more source
THE SEPARATION OF CATHEPSIN FROM MALIGNANT AND NORMAL RAT TISSUE
, 1939 Mary E. Maver
openalex +1 more source
The Development of Malignant Tumours of Mouse Skin after “Initiating” and “Promoting” Stimuli. I. The Effect of a Single Application of 9, 10-Dimethyl-1, 2-Benzanthracene (DMBA), with and without Subsequent Treatment with Croton Oil [PDF]
, 1956 F. J. C. Roe
openalex +1 more source
FEBS Open Bio, EarlyView.Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto +5 more
wiley +1 more source