Results 101 to 110 of about 132,903 (311)

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Epidemiology of Non-Hodgkin Lymphomas in the 20th and at the beginning of the 21st century

Patologìâ, 2014
Aim: to study the dynamics of incidence, mortality, survival of patients with non-Hodgkin lymphomas in the world, Ukraine and Zaporizhzhya region in the 20th and at the beginning of the 21st century.
A. I. Shevchenko, А. M. Sidorenko, E. R. Krohmalnaya   +2 more
doaj   +1 more source

Mitoxantrone is superior to doxorubicin in a multiagent weekly regimen for patients older than 60 with high-grade lymphoma: results of a BNLI randomized trial of PAdriaCEBO versus PMitCEBO [PDF]

, 2001
A prospective, multicenter, randomized trial was undertaken to compare the efficacy and toxicity of adriamycin with mitoxantrone within a 6-drug combination chemotherapy regimen for elderly patients (older than 60 years) with high-grade non-Hodgkin ...
Cunningham, D., Gregory, W., Hancock, B., Hoskin, P., Hudson, G.V., Linch, D., MacLennan, K., Mainwaring, P.N., Norton, A.J., Smith, P.   +9 more
core   +1 more source

Risk of malignant lymphomas in patients with inflammatory bowel disease: a population-based cohort study. [PDF]

BMJ Open Gastroenterol, 2023
Yu J, Refsum E, Wieszczy P, Helsingen LM, Perrin V, Högdén A, Løberg M, Blom J, Bretthauer M, Adami HO, Ye W, Kalager M.   +11 more
europepmc   +1 more source

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Blood and skin-derived Sezary cells: differences in proliferation-index, activation of PI3K/AKT/mTORC1 pathway and its prognostic relevance [PDF]

, 2019
Sézary syndrome (SS) is a rare and aggressive variant of Cutaneous T-Cell Lymphoma characterized by neoplastic distribution mainly involving blood, skin, and lymph-node.
Benucci, Roberto, Bresin, Antonella, Cantonetti, Maria, Caprini, Elisabetta, Cristofoletti, Cristina, D’Atri, Stefania, Frezzolini, Alessandra, Helmer Citterich, Mauro, Monopoli, Alessandro, Monzo, Francesca, Narducci, Maria Grazia, Passarelli, Francesca, Picchio, Maria Cristina, Picozza, Mario, Russo, Giandomenico, Scala, Enrico   +15 more
core   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

A Case of Primary Non-Hodgkin’s Lymphoma of the External Auditory Canal

Case Reports in Otolaryngology, 2013
Lymphomas represent the second most frequent malignant tumor (incidence 2.5%) in the head and neck region. Non-Hodgkin lymphomas (NHLs) present with cervical lymph node involvement, but in 40% extranodal site could be primary involved: nasopharynx, the ...
Luca Bruschini, Andrea De Vito, Susanna Fortunato, Marco Pelosini, Giulia Cervetti, Mario Petrini, Stefano Berrettini   +6 more
doaj   +1 more source

Abdominal multivisceral transplantation [PDF]

, 1995
Under FK506-based immunosuppression, 13 abdominal multivisceral transplantations were performed in 6 children and 7 adults. Of the 13 recipients, 7 (53.8%) are alive and well with functioning grafts after 9 to 31 months.
Abu-Elmagd, K, Demetris, A, Fung, J, Furukawa, H, Nour, B, Reyes, J, Starzl, TE, Todo, S, Tzakis, A   +8 more
core   +1 more source