Results 21 to 30 of about 16,726 (54)

The AMPK-MFN2 axis regulates MAM dynamics and autophagy induced by energy stresses

Autophagy, 2020
Energy deprivation activates the cellular energy sensor AMP-activated protein kinase (AMPK), which in turn induces macroautophagy/autophagy. The mitochondrial-associated ER membrane (MAM) plays a key role in mitochondrial division and autophagy, and the ...
Yongquan Hu, Hao Chen, Luying Zhang, Xiaoying Lin, Xia Li, Haixia Zhuang, Hualin Fan, Tian Meng, Zhengjie He, Haofeng Huang, Qing Gong, Dongxing Zhu, Yiming Xu, Pengcheng He, Longxuan Li, Du Feng   +15 more
semanticscholar   +1 more source

ID-MAM: A Validated Identity and Multi-Attribute Monitoring Method for Commercial Release and Stability Testing of a Bispecific Antibody.

Analytical Chemistry, 2021
Post-translational modifications (PTMs) that impact the safety or efficacy of protein therapeutics are critical quality attributes (CQAs) that need to be controlled to ensure product quality.
A. Evans, Alexander S. Hebert, Joseph J Mulholland, M. Lewis, P. Hu   +4 more
semanticscholar   +1 more source

Cal‘MAM’ity at the Endoplasmic Reticulum-Mitochondrial Interface: A Potential Therapeutic Target for Neurodegeneration and Human Immunodeficiency Virus-Associated Neurocognitive Disorders

Frontiers in Neuroscience, 2021
The endoplasmic reticulum (ER) is a multifunctional organelle and serves as the primary site for intracellular calcium storage, lipid biogenesis, protein synthesis, and quality control.
J. Proulx, I. Park, K. Borgmann
semanticscholar   +1 more source

Rab32 uses its effector reticulon 3L to trigger autophagic degradation of mitochondria-associated membrane (MAM) proteins

Biology Direct, 2021
Rab32 is a small GTPase associated with multiple organelles but is particularly enriched at the endoplasmic reticulum (ER). Here, it controls targeting to mitochondria-ER contacts (MERCs), thus influencing composition of the mitochondria-associated ...
M. Herrera-Cruz, Megan C Yap, Nasser Tahbaz, Keelie Phillips, L. Thomas, G. Thomas, T. Simmen   +6 more
semanticscholar   +1 more source

CNPY2 Aggravates Renal Tubular Cell Ferroptosis in Diabetic Nephropathy by Regulating PERK/ATF4/CHAC1 Pathway and MAM Integrity

Advancement of science
Ferroptosis is emerging as a novel mechanism for understanding renal tubular injury in diabetic nephropathy (DN). The mitochondria‐associated endoplasmic reticulum membrane (MAM) plays a crucial role in the regulation of numerous cellular processes ...
Jingfang Chen, Dongwei Liu, Lei Lei, Ting Liu, S. Pan, Hui Wang, Yong Liu, Y. Qiao, Zhangsuo Liu, Qi Feng   +9 more
semanticscholar   +1 more source

MAM kinases: physiological roles, related diseases, and therapeutic perspectives—a systematic review

Cellular & Molecular Biology Letters
Mitochondria-associated membranes (MAMs) are tethering regions amid the membranes of the endoplasmic reticulum (ER) and mitochondria. They are a lipid raft-like structure occupied by various proteins that facilitates signal transduction between the two ...
A. Mohan, P. Talwar
semanticscholar   +1 more source

Minimal ablative margin (MAM) assessment with image fusion: an independent predictor for local tumor progression in hepatocellular carcinoma after stereotactic radiofrequency ablation

European Radiology, 2020
Objectives To assess the minimal ablative margin (MAM) by image fusion of intraprocedural pre- and post-ablation contrast-enhanced CT images and to evaluate if it can predict local tumor progression (LTP) independently.
G. Laimer, P. Schullian, N. Jaschke, D. Putzer, G. Eberle, Amilcar Alzaga, B. Odisio, R. Bale   +7 more
semanticscholar   +1 more source

Mitochondria-associated endoplasmic reticulum membrane (MAM): a dark horse for diabetic cardiomyopathy treatment

Cell Death Discovery
Diabetic cardiomyopathy (DCM), an important complication of diabetes mellitus (DM), is one of the most serious chronic heart diseases and has become a major cause of heart failure worldwide.
Yong Liu, Jin-Ling Huo, Kaidi Ren, S. Pan, Hengdao Liu, Yifeng Zheng, Jingfang Chen, Y. Qiao, Yang Yang, Q. Feng   +9 more
semanticscholar   +1 more source

Yes, MAM!

Molecular & Cellular Oncology, 2021
Regulation of cell life and death by members of the BCL-2 family of proteins occurs at the mitochondria. Large portions of the mitochondria’s outer membrane are found in tight approximation with the endoplasmic reticulum (ER), known as mitochondria ...
R. Means, Samuel G Katz
semanticscholar   +1 more source

Metal Additive Manufacturing (MAM) Applications in Production of Vehicle Parts and Components—A Review

Metals
In this article, the significance of additive manufacturing techniques in the production of vehicle parts over the past several years is highlighted.
B. Sarzyński, L. Śnieżek, K. Grzelak
semanticscholar   +1 more source