Results 31 to 40 of about 16,726 (54)

Peripubertal mGluR2/3 Agonist Treatment Prevents Hippocampal Dysfunction and Dopamine System Hyperactivity in Adulthood in MAM Model of Schizophrenia.

Schizophrenia bulletin, 2021
Pomaglumetad methionil (POM), a group 2 metabotropic glutamate receptor (mGluR2/3) agonist, showed promise as a novel antipsychotic in preclinical research but failed to show efficacy in clinical trials, though it has been suggested that it may be ...
S. Sonnenschein, A. Grace
semanticscholar   +1 more source

The SIRT3-ATAD3A axis regulates MAM dynamics and mitochondrial calcium homeostasis in cardiac hypertrophy

International Journal on Biological Sciences
Mitochondria are energy-producing organelles that are mobile and harbor dynamic network structures. Although mitochondria and endoplasmic reticulum (ER) play distinct cellular roles, they are physically connected to maintain functional homeostasis ...
Zeyu Li, Ou Hu, Suowen Xu, Chenjia Lin, Wenjing Yu, Dinghu Ma, Jing Lu, Peiqing Liu   +7 more
semanticscholar   +1 more source

MAPK1 Mediates MAM Disruption and Mitochondrial Dysfunction in Diabetic Kidney Disease via the PACS-2-Dependent Mechanism

International Journal on Biological Sciences
Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease (ESRD). Mitochondrial dysfunction in renal tubules, occurring early in the disease, is linked to the development of DKD, although the underlying pathways remain unclear. Here, we
Shanshan Liu, Shuai Han, Cuili Wang, Hongjun Chen, Qian Xu, Shi Feng, Yu-cheng Wang, Jihong Yao, Qin Zhou, Xuanli Tang, Li Lin, Lidan Hu, Alan J. Davidson, Bing Yang, C. Ye, Fan Yang, Jianhua Mao, Chao Tong, Jianghua Chen, Hong Jiang   +19 more
semanticscholar   +1 more source

So close, yet so far away: the relationship between MAM and cardiac disease

Frontiers in Cardiovascular Medicine
Mitochondria-associated membrane (MAM) serve as crucial contact sites between mitochondria and the endoplasmic reticulum (ER). Recent research has highlighted the significance of MAM, which serve as a platform for various protein molecules, in processes ...
Bo Lu, Xiaozhe Chen, Yulong Ma, Mingtai Gui, Lei Yao, Jianhua Li, Mingzhu Wang, Xunjie Zhou, D. Fu   +8 more
semanticscholar   +1 more source

Connection Lost, MAM: Errors in ER–Mitochondria Connections in Neurodegenerative Diseases

Brain Science, 2021
Mitochondria associated membranes (MAMs), as the name suggests, are the membranes that physically and biochemically connect mitochondria with endoplasmic reticulum.
A. Johri, Abhishek Chandra
semanticscholar   +1 more source

Prepubertal Environmental Enrichment Prevents Dopamine Dysregulation and Hippocampal Hyperactivity in MAM Schizophrenia Model Rats.

Biological Psychiatry, 2020
BACKGROUND Schizophrenia (SCZ) is a neurodevelopmental disorder with a progressive, prolonged course. Early prevention for SCZ is promising but overall lacks support from preclinical evidence. Previous studies have tested environmental enrichment (EE) in
Xiyu Zhu, A. Grace
semanticscholar   +1 more source

The silence of the fats: A mam's story about Alzheimer.

Neurobiology of Disease, 2020
The discovery of contact sites was a breakthrough in cell biology. We have learned that an organelle cannot function in isolation, and that many cellular functions depend on communication between two or more organelles.
R. Agrawal, J. Montesinos, D. Larrea, E. Area-Gómez, M. Pera   +4 more
semanticscholar   +1 more source

A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease

Cell Death and Disease, 2018
In the last few years, increased emphasis has been devoted to understanding the contribution of mitochondria-associated endoplasmic reticulum (ER) membranes (MAM) to human pathology in general, and neurodegenerative diseases in particular. A major reason
E. Area-Gómez, Ad J C de Groof, E. Bonilla, J. Montesinos, K. Tanji, I. Boldogh, L. Pon, E. Schon   +7 more
semanticscholar   +1 more source

Insights on current and novel antipsychotic mechanisms from the MAM model of schizophrenia.

Neuropharmacology, 2020
Current antipsychotic drugs (APDs) act on D2 receptors, and preclinical studies demonstrate that repeated D2 antagonist administration downregulates spontaneously active DA neurons by producing overexcitation-induced inactivation of firing ...
S. Sonnenschein, A. Grace
semanticscholar   +1 more source

Swimming Differentially Affects T2DM-Induced Skeletal Muscle ER Stress and Mitochondrial Dysfunction Related to MAM

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy, 2020
Purpose Mitochondrial dysfunction and endoplasmic reticulum stress (ERS) are associated with metabolic diseases such as obesity and Type 2 diabetes mellitus (T2DM).
Zhe Zhang, D. Cui, Tan Zhang, Yi Sun, Shuzhe Ding   +4 more
semanticscholar   +1 more source