Results 1 to 10 of about 461 (119)

Experimental Resurrection of Ancestral Mammalian CPEB3 Ribozymes Reveals Deep Functional Conservation. [PDF]

Mol Biol Evol, 2021
Self-cleaving ribozymes are genetic elements found in all domains of life, but their evolution remains poorly understood. A ribozyme located in the second intron of the cytoplasmic polyadenylation binding protein 3 gene (CPEB3) shows high sequence ...
Bendixsen DP, Pollock TB, Peri G, Hayden EJ.   +3 more
europepmc   +7 more sources

Secondary structure confirmation and localization of Mg2+ ions in the mammalian CPEB3 ribozyme. [PDF]

RNA, 2016
Most of today's knowledge of the CPEB3 ribozyme, one of the few small self-cleaving ribozymes known to occur in humans, is based on comparative studies with the hepatitis delta virus (HDV) ribozyme, which is highly similar in cleavage mechanism and ...
Skilandat M, Rowinska-Zyrek M, Sigel RK.
europepmc   +7 more sources

CPEB3 is associated with human episodic memory [PDF]

Frontiers in Behavioral Neuroscience, 2009
Cytoplasmic polyadenylation element-binding (CPEB) proteins are crucial for synaptic plasticity and memory in model organisms. A highly conserved, mammalian-specific short intronic sequence within CPEB3 has been identified as a ribozyme with self ...
Christian Vogler, Christian Vogler, Klara Spalek, Klara Spalek, Amanda Aerni, Philippe Demougin, Philippe Demougin, Ariane Müller, Ariane Müller, Kim-Dung Huynh, Kim-Dung Huynh, Andreas Papassotiropoul, Andreas Papassotiropoul, Dominique J F De Quervain, Dominique J F De Quervain   +14 more
doaj   +8 more sources

Silencing of amyloid precursor protein expression using a new engineered delta ribozyme. [PDF]

Int J Alzheimers Dis, 2012
Alzheimer′s disease (AD) etiological studies suggest that an elevation in amyloid‐β peptides (Aβ) level contributes to aggregations of the peptide and subsequent development of the disease. The major constituent of these amyloid peptides is the 1 to 40–42 residue peptide (Aβ40−42) derived from amyloid protein precursor (APP).
Ben Aissa M, April MC, Bergeron LJ, Perreault JP, Levesque G.   +4 more
europepmc   +7 more sources

The human HDV-like CPEB3 ribozyme is intrinsically fast-reacting. [PDF]

Biochemistry, 2010
Self-cleaving RNAs have recently been identified in mammalian genomes. A small ribozyme related in structure to the hepatitis delta virus (HDV) ribozyme occurs in a number of mammals, including chimpanzees and humans, within an intron of the CPEB3 gene ...
Chadalavada DM, Gratton EA, Bevilacqua PC.   +2 more
europepmc   +2 more sources

Inhibition of Cpeb3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs and enhances object location memory. [PDF]

Elife
A self-cleaving ribozyme that maps to an intron of the cytoplasmic polyadenylation element-binding protein 3 (Cpeb3) gene is thought to play a role in human episodic memory, but the underlying mechanisms mediating this effect are not known. We tested the
Chen CC, Han J, Chinn CA, Rounds JS, Li X, Nikan M, Myszka M, Tong L, Passalacqua LFM, Bredy T, Wood MA, Luptak A.   +11 more
europepmc   +2 more sources

Hepatitis delta virus: a peculiar virus. [PDF]

Adv Virol, 2013
The hepatitis delta virus (HDV) is distributed worldwide and related to the most severe form of viral hepatitis. HDV is a satellite RNA virus dependent on hepatitis B surface antigens to assemble its envelope and thus form new virions and propagate infection. HDV has a small 1.7 Kb genome making it the smallest known human virus.
Alves C, Branco C, Cunha C.
europepmc   +2 more sources

Inhibition of CPEB3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs, and enhances object location memory

bioRxiv, 2023
A self-cleaving ribozyme that maps to an intron of the cytoplasmic polyadenylation element binding protein 3 (CPEB3) gene is thought to play a role in human episodic memory, but the underlying mechanisms mediating this effect are not known. We tested the
Claire C. Chen, Joseph Han, Carlene A. Chinn, Jacob S Rounds, Xiang Li, Mehran Nikan, Marie Myszka, L. Tong, Luiz F. M. Passalacqua, T. Bredy, M. Wood, A. Lupták   +11 more
semanticscholar   +1 more source

The CPEB3 ribozyme modulates hippocampal-dependent memory

bioRxiv, 2021
A self-cleaving ribozyme mapping to an intron of the cytoplasmic polyadenylation element binding protein 3 (CPEB3) gene has been suggested to play a role in human episodic memory, but the underlying mechanisms mediating this effect are not known.
Claire C. Chen, Joseph Han, Carl Chinn, Xiang Li, Mehran Nikan, Marie Myszka, L. Tong, T. Bredy, M. Wood, A. Lupták   +9 more
semanticscholar   +1 more source

Reconstitution of Multi-Protein Complexes through Ribozyme-Assisted Polycistronic Co-Expression

ACS Synthetic Biology, 2022
In living cells, proteins often exert their functions by interacting with other proteins forming protein complexes. Obtaining homogeneous samples of protein complexes with correct fold and stoichiometry is critical for its biochemical and biophysical ...
Yan Liu, Zihan Wu, Damu Wu, N. Gao, Jinzhong Lin   +4 more
semanticscholar   +1 more source