Experimental Resurrection of Ancestral Mammalian CPEB3 Ribozymes Reveals Deep Functional Conservation [PDF]
Molecular Biology and Evolution, 2021 Abstract Self-cleaving ribozymes are genetic elements found in all domains of life, but their evolution remains poorly understood. A ribozyme located in the second intron of the cytoplasmic polyadenylation binding protein 3 gene (CPEB3) shows high sequence conservation in mammals, but little is known about the functional conservation of ...
Devin P. Bendixsen +3 more
europepmc +5 more sources
Secondary structure confirmation and localization of Mg2+ ions in the mammalian CPEB3 ribozyme [PDF]
RNA, 2016 Most of today's knowledge of the CPEB3 ribozyme, one of the few small self-cleaving ribozymes known to occur in humans, is based on comparative studies with the hepatitis delta virus (HDV) ribozyme, which is highly similar in cleavage mechanism and probably also in structure. Here we present detailed NMR studies of the CPEB3 ribozyme in order to verify
Skilandat, Miriam +2 more
europepmc +4 more sources
CPEB3 is associated with human episodic memory [PDF]
Frontiers in Behavioral Neuroscience, 2009 Cytoplasmic polyadenylation element-binding (CPEB) proteins are crucial for synaptic plasticity and memory in model organisms. A highly conserved, mammalian-specific short intronic sequence within CPEB3 has been identified as a ribozyme with self ...
Christian Vogler +14 more
doaj +7 more sources
Hepatitis delta virus: a peculiar virus. [PDF]
Adv Virol, 2013 The hepatitis delta virus (HDV) is distributed worldwide and related to the most severe form of viral hepatitis. HDV is a satellite RNA virus dependent on hepatitis B surface antigens to assemble its envelope and thus form new virions and propagate infection. HDV has a small 1.7 Kb genome making it the smallest known human virus.
Alves C, Branco C, Cunha C.
europepmc +5 more sources
Silencing of amyloid precursor protein expression using a new engineered delta ribozyme. [PDF]
Int J Alzheimers Dis, 2012 Alzheimer′s disease (AD) etiological studies suggest that an elevation in amyloid‐β peptides (Aβ) level contributes to aggregations of the peptide and subsequent development of the disease. The major constituent of these amyloid peptides is the 1 to 40–42 residue peptide (Aβ40−42) derived from amyloid protein precursor (APP).
Ben Aissa M +4 more
europepmc +7 more sources
Evolution and Diversity of the Human Hepatitis D Virus Genome [PDF]
Advances in Bioinformatics, Volume 2010, Issue 1, 2010., 2010 Human hepatitis delta virus (HDV) is the smallest RNA virus in genome. HDV genome is divided into a viroid‐like sequence and a protein‐coding sequence which could have originated from different resources and the HDV genome was eventually constituted through RNA recombination.
Chi-Ruei Huang +2 more
wiley +4 more sources
RNA sequence to structure analysis from comprehensive pairwise mutagenesis of multiple self-cleaving ribozymes. [PDF]
Elife, 2023 Self-cleaving ribozymes are RNA molecules that catalyze the cleavage of their own phosphodiester backbones. These ribozymes are found in all domains of life and are also a tool for biotechnical and synthetic biology applications.
Roberts JM +4 more
europepmc +4 more sources
RNA target highlights in CASP15: Evaluation of predicted models by structure providers
Proteins: Structure, Function, and Bioinformatics, Volume 91, Issue 12, Page 1600-1615, December 2023., 2023 Abstract The first RNA category of the Critical Assessment of Techniques for Structure Prediction competition was only made possible because of the scientists who provided experimental structures to challenge the predictors. In this article, these scientists offer a unique and valuable analysis of both the successes and areas for improvement in the ...
Rachael C. Kretsch +15 more
wiley +1 more source
The Metabolome Weakens RNA Thermodynamic Stability and Strengthens RNA Chemical Stability. [PDF]
Biochemistry, 2022 Sieg JP +4 more
europepmc +1 more source
Predicting higher-order mutational effects in an RNA enzyme by machine learning of high-throughput experimental data. [PDF]
Front Mol Biosci, 2022 Beck JD +6 more
europepmc +1 more source