Results 101 to 110 of about 461 (119)

New Insights into the Dependence of CPEB3 Ribozyme Cleavage on Mn2+ and Mg2.

Journal of Physical Chemistry Letters
CPEB3 ribozyme is a self-cleaving RNA that occurs naturally in mammals and requires divalent metal ions for efficient activity. Ribozymes exhibit preferences for specific metal ions, but the exact differences in the catalytic mechanisms of various metal ...
Yaoyao Zhang, Jing Zhang, Hengjia Wan, Ziwei Wu, Huangtao Xu, Zhe Zhang, Yujuan Wang, Junfeng Wang   +7 more
semanticscholar   +1 more source

Cell-Specific Control of Mammalian Gene Expression Using DNA Repair Inducible Ribozyme Switches.

Angewandte Chemie
The ability to control gene expression is vital for elucidating gene functions and developing next-generation therapeutics. Current techniques are challenged by the lack of cell-specific control designs or immunogenicity risk from foreign proteins.
Jieling Hong, Zhen Jiang, Zhenkun Wu, Jian-Hui Jiang   +3 more
semanticscholar   +1 more source

Hydrolytic endonucleolytic ribozyme (HYER) is programmable for sequence-specific DNA cleavage

Science
Ribozymes are catalytic RNAs with diverse functions including self-splicing and polymerization. This work aims to discover natural ribozymes that behave as hydrolytic and sequence-specific DNA endonucleases, which could be repurposed as DNA manipulation ...
Zi-Xian Liu, Shouyue Zhang, Hanmo Zhu, Zhi-Hang Chen, Yun Yang, Long-Qi Li, Yuan Lei, Yun Liu, Danyuan Li, Ao Sun, Cheng-Ping Li, Shun-Qing Tan, Gao-Li Wang, Jie-Yi Shen, Shuai Jin, Caixia Gao, J. Liu   +16 more
semanticscholar   +1 more source

Ribozyme-activated mRNA trans-ligation enables large gene delivery to treat muscular dystrophies.

Science
Ribozymes are small catalytic RNA sequences capable of nucleotide-specific self-cleavage found widespread in nature. Ribozyme cleavage generates distinct 2',3'-phosphate and 5'-hydroxyl termini that resemble substrates for recently characterized RNA ...
Sean R Lindley, K. C. Subbaiah, Fnu Priyanka, Pornthida Poosala, Yijie Ma, Leila Jalinous, Jason A West, William A Richardson, Tamlyn N Thomas, Douglas M Anderson   +9 more
semanticscholar   +1 more source

Mapping the fibril core of the prion subdomain of the mammalian CPEB3 that is involved in long term memory retention.

Journal of Molecular Biology, 2021
Dhanya S. Reselammal, Faina Pinhero, Rahul Sharma, O. H. Muhammed Shafeek, S. Srinivasula, Vinesh Vijayan   +5 more
semanticscholar   +1 more source

A Genomewide Search for Ribozymes Reveals an HDV-Like Sequence in the Human CPEB3 Gene

Science, 2006
K. Salehi-Ashtiani, A. Lupták, A. Litovchick, J. Szostak   +3 more
semanticscholar   +1 more source

Title Role of CPEB3 ribozyme in memory formation

, 2020
Claire C. Chen
semanticscholar   +1 more source

The first crystal structure of the human and the chimp CPEB3 ribozyme: a snapshot of the catalytic core reveals an unexpected fold of the HDV-like ribozymes

, 2020
Anna Ilaria Przytula-Mally
semanticscholar   +1 more source

The 5′‐AG5CC‐3′ Fragment from the Human CPEB3 Ribozyme Forms an Ultrastable Parallel RNA G‐Quadruplex

ChemBioChem, 2017
Katharina Kulikov, Senada Nožinović, S. Kath‐Schorr   +2 more
semanticscholar   +1 more source

Engineering Aptazyme Switches for Conditional Gene Expression in Mammalian Cells Utilizing an In Vivo Screening Approach.

Methods in molecular biology, 2021
Charlotte Rehm, Benedikt Klauser, M. Finke, J. Hartig   +3 more
semanticscholar   +1 more source