Evolution and Diversity of the Human Hepatitis D Virus Genome [PDF]
Advances in Bioinformatics, Volume 2010, Issue 1, 2010., 2010 Human hepatitis delta virus (HDV) is the smallest RNA virus in genome. HDV genome is divided into a viroid‐like sequence and a protein‐coding sequence which could have originated from different resources and the HDV genome was eventually constituted through RNA recombination.
Chi-Ruei Huang +2 more
wiley +4 more sources
RNA sequence to structure analysis from comprehensive pairwise mutagenesis of multiple self-cleaving ribozymes. [PDF]
Elife, 2023 Self-cleaving ribozymes are RNA molecules that catalyze the cleavage of their own phosphodiester backbones. These ribozymes are found in all domains of life and are also a tool for biotechnical and synthetic biology applications.
Roberts JM +4 more
europepmc +4 more sources
Hepatitis Delta Virus (HDV) and Delta-Like Agents: Insights Into Their Origin. [PDF]
Front Microbiol, 2021 Hepatitis delta virus (HDV) is a human pathogen, and the only known species in the genus Deltavirus. HDV is a satellite virus and depends on the hepatitis B virus (HBV) for packaging, release, and transmission.
Netter HJ +3 more
europepmc +3 more sources
Solution structure and metal ion binding sites of the human CPEB3 ribozyme’s P4 domain [PDF]
JBIC Journal of Biological Inorganic Chemistry, 2014 Three ribozymes are known to occur in humans, the CPEB3 ribozyme, the CoTC ribozyme, and the hammerhead ribozyme. Here, we present the NMR solution structure of a well-conserved motif within the CPEB3 ribozyme, the P4 domain.
M. Skilandat +2 more
semanticscholar +2 more sources
Hidden ribozymes in eukaryotic genome sequence. [PDF]
F1000 Biol Rep, 2010 The small self-cleaving ribozymes fold into complex tertiary structures to promote autocatalytic cleavage or ligation at a precise position within their sequence. Until recently, relatively few examples had been identified.
Ryder SP.
europepmc +3 more sources
Identification of HDV-like theta ribozymes involved in tRNA-based recoding of gut bacteriophages. [PDF]
Nat CommunTrillions of microorganisms, collectively known as the microbiome, inhabit our bodies with the gut microbiome being of particular interest in biomedical research. Bacteriophages, the dominant virome constituents, can utilize suppressor tRNAs to switch to
Kienbeck K +5 more
europepmc +3 more sources
Chemistry and Biology of Self-Cleaving Ribozymes. [PDF]
Trends Biochem Sci, 2015 Jimenez RM, Polanco JA, Lupták A.
europepmc +2 more sources
Improved Computational Prediction of Function and Structural Representation of Self-Cleaving Ribozymes with Enhanced Parameter Selection and Library Design [PDF]
, 2022 Biomolecules could be engineered to solve many societal challenges, including disease diagnosis and treatment, environmental sustainability, and food security.
Beck, James D.
core +2 more sources
Characterization of the trans Watson-Crick GU base pair located in the catalytic core of the antigenomic HDV ribozyme. [PDF]
PLoS One, 2012 The HDV ribozyme’s folding pathway is, by far, the most complex folding pathway elucidated to date for a small ribozyme. It includes 6 different steps that have been shown to occur before the chemical cleavage.
Lévesque D, Reymond C, Perreault JP.
europepmc +5 more sources
RNA-Puzzles Round V: blind predictions of 23 RNA structures. [PDF]
Nat MethodsRNA-Puzzles is a collective endeavor dedicated to the advancement and improvement of RNA three-dimensional structure prediction. With agreement from structural biologists, RNA structures are predicted by modeling groups before publication of the ...
Bu F +98 more
europepmc +3 more sources