Results 11 to 20 of about 154 (101)

Hepatitis Delta Virus (HDV) and Delta-Like Agents: Insights Into Their Origin. [PDF]

Front Microbiol, 2021
Hepatitis delta virus (HDV) is a human pathogen, and the only known species in the genus Deltavirus. HDV is a satellite virus and depends on the hepatitis B virus (HBV) for packaging, release, and transmission.
Netter HJ, Barrios MH, Littlejohn M, Yuen LKW.   +3 more
europepmc   +3 more sources

Hidden ribozymes in eukaryotic genome sequence. [PDF]

F1000 Biol Rep, 2010
The small self-cleaving ribozymes fold into complex tertiary structures to promote autocatalytic cleavage or ligation at a precise position within their sequence. Until recently, relatively few examples had been identified.
Ryder SP.
europepmc   +3 more sources

Identification of HDV-like theta ribozymes involved in tRNA-based recoding of gut bacteriophages. [PDF]

Nat Commun
Trillions of microorganisms, collectively known as the microbiome, inhabit our bodies with the gut microbiome being of particular interest in biomedical research. Bacteriophages, the dominant virome constituents, can utilize suppressor tRNAs to switch to
Kienbeck K, Malfertheiner L, Zelger-Paulus S, Johannsen S, von Mering C, Sigel RKO.   +5 more
europepmc   +3 more sources

Improved Computational Prediction of Function and Structural Representation of Self-Cleaving Ribozymes with Enhanced Parameter Selection and Library Design [PDF]

, 2022
Biomolecules could be engineered to solve many societal challenges, including disease diagnosis and treatment, environmental sustainability, and food security.
Beck, James D.
core   +2 more sources

Characterization of the trans Watson-Crick GU base pair located in the catalytic core of the antigenomic HDV ribozyme. [PDF]

PLoS One, 2012
The HDV ribozyme’s folding pathway is, by far, the most complex folding pathway elucidated to date for a small ribozyme. It includes 6 different steps that have been shown to occur before the chemical cleavage.
Lévesque D, Reymond C, Perreault JP.
europepmc   +5 more sources

RNA-Puzzles Round V: blind predictions of 23 RNA structures. [PDF]

Nat Methods
RNA-Puzzles is a collective endeavor dedicated to the advancement and improvement of RNA three-dimensional structure prediction. With agreement from structural biologists, RNA structures are predicted by modeling groups before publication of the ...
Bu F, Adam Y, Adamiak RW, Antczak M, de Aquino BRH, Badepally NG, Batey RT, Baulin EF, Boinski P, Boniecki MJ, Bujnicki JM, Carpenter KA, Chacon J, Chen SJ, Chiu W, Cordero P, Das NK, Das R, Dawson WK, DiMaio F, Ding F, Dock-Bregeon AC, Dokholyan NV, Dror RO, Dunin-Horkawicz S, Eismann S, Ennifar E, Esmaeeli R, Farsani MA, Ferré-D'Amaré AR, Geniesse C, Ghanim GE, Guzman HV, Hood IV, Huang L, Jain DS, Jaryani F, Jin L, Joshi A, Karelina M, Kieft JS, Kladwang W, Kmiecik S, Koirala D, Kollmann M, Kretsch RC, Kurciński M, Li J, Li S, Magnus M, Masquida B, Moafinejad SN, Mondal A, Mukherjee S, Nguyen THD, Nikolaev G, Nithin C, Nye G, Pandaranadar Jeyeram IPN, Perez A, Pham P, Piccirilli JA, Pilla SP, Pluta R, Poblete S, Ponce-Salvatierra A, Popenda M, Popenda L, Pucci F, Rangan R, Ray A, Ren A, Sarzynska J, Sha CM, Stefaniak F, Su Z, Suddala KC, Szachniuk M, Townshend R, Trachman RJ, Wang J, Wang W, Watkins A, Wirecki TK, Xiao Y, Xiong P, Xiong Y, Yang J, Yesselman JD, Zhang J, Zhang Y, Zhang Z, Zhou Y, Zok T, Zhang D, Zhang S, Żyła A, Westhof E, Miao Z.   +98 more
europepmc   +3 more sources

Improving the Ribozyme Toolbox: From Structure-Function Insights to Synthetic Biology Applications [PDF]

, 2022
Self-cleaving ribozymes are a naturally occurring class of catalytically active RNA molecules which cleave their own phosphate backbone. In nature, self-cleaving ribozymes are best known for their role in processing concatamers of viral genomes into ...
Roberts, Jessica Michelle
core   +1 more source

Dendritic targeting of short and long 3\u2032 UTR BDNF mRNA is regulated by BDNF or NT-3 and distinct sets of RNA-binding proteins [PDF]

, 2015
Sorting of mRNAs in neuronal dendrites relies upon inducible transport mechanisms whose molecular bases are poorly understood. We investigated here the mechanism of inducible dendritic targeting of rat brain-derived neurotrophic factor (BDNF) mRNAs as a ...
Alberto ePallavicini, Andrea eColliva, Annalisa eVicario, Antonia eRatti, Antonia eRatti, Barbara eBardoni, Claudia eColombrita, Claudia eColombrita, Enrico eTongiorgi, Gabriele eBaj, Kevin R Jones, Laetitia eDavidovic, Lucasz eGricman   +12 more
core   +5 more sources

Pioneering role of RNA in the early evolution of life. [PDF]

Genet Mol Biol
The catalytic, regulatory and structural properties of RNA, combined with their extraordinary ubiquity in cellular processes, are consistent with the proposal that this molecule played a much more conspicuous role in heredity and metabolism during the ...
Muñoz-Velasco I, Cruz-González A, Hernández-Morales R, Campillo-Balderas JA, Cottom-Salas W, Jácome R, Vázquez-Salazar A.   +6 more
europepmc   +4 more sources

The potential versatility of RNA catalysis [PDF]

, 2021
It is commonly thought that in the early development of life on this planet RNA would have acted both as a store of genetic information and as a catalyst.
Lilley, David, Wilson, Timothy J.
core   +2 more sources