Solution structure and metal ion binding sites of the human CPEB3 ribozyme’s P4 domain [PDF]
, 2014 Three ribozymes are known to occur in humans, the CPEB3 ribozyme, the CoTC ribozyme, and the hammerhead ribozyme. Here, we present the NMR solution structure of a well-conserved motif within the CPEB3 ribozyme, the P4 domain.
Rowinska-Zyrek, Magdalena +2 more
core +1 more source
Intronic hammerhead ribozymes in mRNA biogenesis [PDF]
, 2012 [EN] Small self-cleaving ribozymes are a group of natural RNAs that are capable of catalyzing their own and sequence-specific endonucleolytic cleavage.
García Robles, Inmaculada +2 more
core +1 more source
Identification of an hepatitis delta virus-like ribozyme at the mRNA 5′-end of the L1Tc retrotransposon from Trypanosoma cruzi [PDF]
, 2011 L1Tc is a non-LTR LINE element from Trypanosoma cruzi that encodes its transposition machinery and bears an internal promoter. Herewith, we report the identification of an in vitro active hepatitis delta virus-like ribozyme located in the first 77 nt at ...
Alonso, Carlos +4 more
core +2 more sources
Empirical Investigations OF RNA Fitness Landscapes: Harnessing the Power of High-Throughput Sequencing and Evolutionary Simulations [PDF]
, 2018 Fitness landscapes or adaptive landscapes represent the mapping of genotype (sequence) to phenotype (function or fitness). Originally proposed as a metaphor to envision evolutionary processes and mutational interactions, the fitness landscape has ...
Bendixsen, Devin Pratt
core +1 more source
Evaluating Performance of Different RNA Secondary Structure Prediction Programs Using Self-cleaving Ribozymes [PDF]
Accurate identification of the correct, biologically relevant RNA structures is critical to understanding various aspects of RNA biology since proper folding represents the key to the functionality of all types of RNA molecules and plays pivotal roles in
Chen, Junjie +6 more
core +2 more sources
A manganese-dependent ribozyme in the 3′-untranslated region of Xenopus Vg1 mRNA [PDF]
, 2008 The smallest catalytic RNA identified to date is a manganese-dependent ribozyme that requires only a complex between GAAA and UUU to effect site-specific cleavage.
Hartland, Emilia I. +2 more
core +7 more sources
Searching genomes for ribozymes and riboswitches [PDF]
, 2007 A discussion of experimental approaches and theoretical difficulties in the identification of ribozymes with novel catalytic ...
Hammann, Christian, Westhof, Eric
core +3 more sources
Non Coding RNAs and Viruses in the Framework of the Phylogeny of the Genes, Epigenesis and Heredity [PDF]
, 2012 The origin of genes is one of the most enigmatic events in the origin of life. It has been suggested that noncoding (nc) RNA was probably a precursor in the formation of the first polypeptide, and also at the origin of the first manifestation of life and
Ahmad +100 more
core +3 more sources
Solution structure and metal ion binding sites of the human CPEB3 ribozyme's P4 domain [PDF]
, 2019 Three ribozymes are known to occur in humans, the CPEB3 ribozyme, the CoTC ribozyme, and the hammerhead ribozyme. Here, we present the NMR solution structure of a well-conserved motif within the CPEB3 ribozyme, the P4 domain.
Rowinska-Zyrek, Magdalena +2 more
core
From Enigma to Revelation: Unravelling Biological Functions of Ubiquitous Small Ribozymes [PDF]
RNA, widely recognized as an information-carrier molecule, is capable of catalyzing essential biological processes through ribozymes. Despite their ubiquity, specific functions in a biological context and phenotypes based on the ribozymes' activity are ...
Johannsen, Silke +5 more
core +2 more sources