Identification of Hammerhead Ribozymes in All Domains of Life Reveals Novel Structural Variations [PDF]
, 2011 Hammerhead ribozymes are small self-cleaving RNAs that promote strand scission by internal phosphoester transfer. Comparative sequence analysis was used to identify numerous additional representatives of this ribozyme class than were previously known ...
A Khvorova +78 more
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Pr77 and L1TcRz: A dual system within the 5′-end of L1Tc retrotransposon, internal promoter and HDV-like ribozyme [PDF]
The sequence corresponding to the first 77 nucleotides of the L1Tc and NARTc non-LTR retrotransposons from Trypanosoma cruzi is an internal promoter (Pr77) that generates abundant, although poorly translatable, un-spliced transcripts.
Alonso, Carlos +4 more
core +2 more sources
Ribozymes of the RNA World: Investigating Ancient Enzymes through Modern Self-Cleaving Ribozymes. [PDF]
, 2016 Ribozymes are RNAs that can perform catalytic functions. The discovery of ribozymes was an important milestone in science because it not only opened new avenues of research but also provided insights into the origins of life on Earth.
Mir, Aamir
core +1 more source
Diversity and evolution of viroids and viroid-like RNA agents [PDF]
Viroids are the smallest and simplest known pathogens. Comprised of circular noncoding RNA, these agents can cause fatal diseases in plants. Although other viroid-like agents such as satellite RNAs, ribozyviruses, and retrozymes have been discovered, the
Lee, Benjamin
core +2 more sources
Hepatita cronica delta: de la descoperire la tratamente noi [PDF]
, 2021 Nicolae TestemitanuState University of Medicine and Pharmacy of the Republic of MoldovaIntroduction. Hepatitis delta virus (HDV) is a small, defective RNA virus that is related more to plant viroids than to other human pathogens.
Turcanu, Adela, Wani, Suhaib Tahir
core
Mining metatranscriptomes reveals a vast world of viroid-like circular RNAs. [PDF]
Cell, 2023 Lee BD +11 more
europepmc +1 more source
Automated Design and Empirical Validation of Hammerhead Ribozymes [PDF]
, 2015 Ribozymes are catalytic RNA molecules. Hammerhead ribozymes are one of a set of ribozymes capable of cleaving RNA molecules, in cis and in trans, without the help of other molecules, such as proteins.
Kharma, Nawwaf
core
Characterization of the hepatitis delta virus small antigen: intracellular localization, structure, multimerization and RNA binding ability [PDF]
, 2013 O vírus da hepatite delta (HDV) é o agente patogénico responsável por uma das formas mais severas de hepatite viral. O genoma consiste numa molécula circular de RNA de cadeia simples de polaridade negativa e apresenta uma única proteína viral, o ...
Alves, Carolina Alpalhão Mantero de Mendonça
core
Optimized expression of small therapeutic RNAs [PDF]
, 2019 RNA interference (RNAi) provides a powerful tool to elucidate gene function by silencing the expression of a specific gene at the RNA level. The recently discovered CRISPR-Cas9 bacterial immune system can be repurposed to easily create gene mutations and
Gao, Z.
core
Rapid discovery of functional RNA domains. [PDF]
Many strategies have been implemented to enrich an RNA population for a selectable function, but demarcation of the optimal functional motifs or minimal structures within longer libraries remains a lengthy and tedious process.
Cole, Kyle +3 more
core +1 more source