Results 31 to 40 of about 461 (119)

Empirical Investigations OF RNA Fitness Landscapes: Harnessing the Power of High-Throughput Sequencing and Evolutionary Simulations [PDF]

, 2018
Fitness landscapes or adaptive landscapes represent the mapping of genotype (sequence) to phenotype (function or fitness). Originally proposed as a metaphor to envision evolutionary processes and mutational interactions, the fitness landscape has ...
Bendixsen, Devin Pratt
core   +1 more source

Abstract 3180: Suppression of the CPEB3 ribozyme modulates the progression of glioblastoma

Cancer Research
Glioblastoma multiforme (GBM) is the most aggressive primary malignant brain tumor in adults, with a poor prognosis that highlights a dire clinical need for innovative therapeutic interventions.
Claire C. Chen, Eric Wang, Lily Tong, Mehran Nikan, D. Bota, Claudia A. Benavente, A. Lupták   +6 more
semanticscholar   +1 more source

Direct screening for ribozyme activity in mammalian cells.

Chemical Communications, 2017
Engineered ribozymes are powerful tools for manipulating gene expression in living cells. However, identification of active ribozymes in mammalian cells has relied on empirical assays of a limited number of arbitrarily chosen ribozymes.
Yoko Nomura, Hsiao-Chiao Chien, Y. Yokobayashi   +2 more
semanticscholar   +1 more source

Dendritic targeting of short and long 3\u2032 UTR BDNF mRNA is regulated by BDNF or NT-3 and distinct sets of RNA-binding proteins [PDF]

, 2015
Sorting of mRNAs in neuronal dendrites relies upon inducible transport mechanisms whose molecular bases are poorly understood. We investigated here the mechanism of inducible dendritic targeting of rat brain-derived neurotrophic factor (BDNF) mRNAs as a ...
Alberto ePallavicini, Andrea eColliva, Annalisa eVicario, Antonia eRatti, Antonia eRatti, Barbara eBardoni, Claudia eColombrita, Claudia eColombrita, Enrico eTongiorgi, Gabriele eBaj, Kevin R Jones, Laetitia eDavidovic, Lucasz eGricman   +12 more
core   +5 more sources

A manganese-dependent ribozyme in the 3′-untranslated region of Xenopus Vg1 mRNA [PDF]

, 2008
The smallest catalytic RNA identified to date is a manganese-dependent ribozyme that requires only a complex between GAAA and UUU to effect site-specific cleavage.
Hartland, Emilia I., Huber, Paul W., Kolev, Nikolay G.   +2 more
core   +7 more sources

Searching genomes for ribozymes and riboswitches [PDF]

, 2007
A discussion of experimental approaches and theoretical difficulties in the identification of ribozymes with novel catalytic ...
Hammann, Christian, Westhof, Eric
core   +3 more sources

Non Coding RNAs and Viruses in the Framework of the Phylogeny of the Genes, Epigenesis and Heredity [PDF]

, 2012
The origin of genes is one of the most enigmatic events in the origin of life. It has been suggested that noncoding (nc) RNA was probably a precursor in the formation of the first polypeptide, and also at the origin of the first manifestation of life and
Ahmad, Anaka, Arora, Autran, Azzalin, Backofen, Benne, Benne, Benzer, Benzer, Berger, Berget, Blanc, Bredy, Cavalier-Smith, Cazalla, Chuang, Combelas, Crick, Daniel Frías-Lasserre, de la Peña, Diener, Diener, Dinger, Dinter-Gottlieb, Eddy, Filipowicz, Filée, Fischer, Frías, Frías, Frías, Frías, Geuking, Gilbert, Gott, Koerner, Kurakawa, la Scola, Lee, Levine, Li, Liang, Liu, Lonergan, Lu, Luciano, Martick, María, Mattick, Mattick, Mehler, Mercer, Mieczkowski, Mindell, Moreira, Munker, Navarro, Orom, Palmer, Parris, Pearson, Petronis, Pijlman, Prody, Raman, Reik, Royo, Rubio, Ryan, Salehi-Ashtiani, Satterlee, Schoeftner, Skuse, Smalheiser, Smalheiser, Smalheiser, Smalheiser, Stort, Sánchez, Taft, Taft, Tang, Teixeira, Thakur, Tian, van Blerkom, Villarreal, Villarreal, Villarreal, Villarreal, Wightman, Wilkins, Worobey, Xiong, Yanofsky, Zhang, Zheng, Zheng, Zinder, Úbeda   +100 more
core   +3 more sources

From Enigma to Revelation: Unravelling Biological Functions of Ubiquitous Small Ribozymes [PDF]

RNA, widely recognized as an information-carrier molecule, is capable of catalyzing essential biological processes through ribozymes. Despite their ubiquity, specific functions in a biological context and phenotypes based on the ribozymes' activity are ...
Johannsen, Silke, Kienbeck, Kasimir, Malfertheiner, Lukas, Sigel, Roland K. O., von Mering, Christian, Zelger-Paulus, Susann   +5 more
core   +2 more sources

Solution structure and metal ion binding sites of the human CPEB3 ribozyme's P4 domain [PDF]

, 2019
Three ribozymes are known to occur in humans, the CPEB3 ribozyme, the CoTC ribozyme, and the hammerhead ribozyme. Here, we present the NMR solution structure of a well-conserved motif within the CPEB3 ribozyme, the P4 domain.
Rowinska-Zyrek, Magdalena, Sigel, Roland, Skilandat, Miriam   +2 more
core  

Identification of Hammerhead Ribozymes in All Domains of Life Reveals Novel Structural Variations [PDF]

, 2011
Hammerhead ribozymes are small self-cleaving RNAs that promote strand scission by internal phosphoester transfer. Comparative sequence analysis was used to identify numerous additional representatives of this ribozyme class than were previously known ...
A Khvorova, A Laferriere, A Oren, A Oren, AA Rojas, AC Forster, AC Forster, Adam Roth, AR Kore, C Seehafer, CH Webb, CJ Hutchins, DA Benson, DE Draper, DE Draper, DE Ruffner, DG Eickbush, EA Davidson, EE Regulski, EP Nawrocki, F Eckstein, G Ferbeyre, G Ferbeyre, G Lennon, GA Prody, Gerardo Ferbeyre, H Bolhuis, HG Kang, J Tang, J Tang, JA Esteban, JA Nelson, JB Murray, JC Cochrane, JH Christian, JL Siefert, Jonathan Perreault, K Salehi-Ashtiani, K Salehi-Ashtiani, KJ Hertel, L Martinsen, L Rocheleau, LL Daniels, LM Epstein, M De la Pena, M De la Pena, M De la Pena, M Martick, M Martick, M Safran, MD Canny, NB Leontis, Olivia Popescu, Pascal Chartrand, PP Gardner, R Przybilski, R Przybilski, R Przybilski, RM Jimenez, Ronald R. Breaker, RR Breaker, S Ambros, S Gago, S Graf, SD Nuttall, SL Tang, T Torsvik, TJ Macke, WC Winkler, WG Scott, WL DeLano, Wyeth W. Wasserman, Y Tan, Y Tokumoto, Z Weinberg, Z Weinberg, Z Weinberg, Z Yao, Zasha Weinberg   +78 more
core   +3 more sources