Results 41 to 50 of about 461 (119)
A ligand-dependent hammerhead ribozyme switch for controlling mammalian gene expression.
Molecular Biosystems, 2010 The possibility to externally control gene expression is of fundamental importance in both basic and applied life sciences. Although there are some techniques available to regulate expression in mammalian cells, they rely on the presence of ligand ...
Simon Ausländer +2 more
semanticscholar +1 more source
Massively parallel RNA device engineering in mammalian cells with RNA-Seq
Nature Communications, 2019 Synthetic RNA-based genetic devices dynamically control a wide range of gene-regulatory processes across diverse cell types. However, the limited throughput of quantitative assays in mammalian cells has hindered fast iteration and interrogation of ...
Joy S. Xiang +5 more
semanticscholar +1 more source
Pr77 and L1TcRz: A dual system within the 5′-end of L1Tc retrotransposon, internal promoter and HDV-like ribozyme [PDF]
The sequence corresponding to the first 77 nucleotides of the L1Tc and NARTc non-LTR retrotransposons from Trypanosoma cruzi is an internal promoter (Pr77) that generates abundant, although poorly translatable, un-spliced transcripts.
Alonso, Carlos +4 more
core +2 more sources
CPEB3 Maintains Developmental Competence of the Oocyte
CellsMammalian oocyte development depends on the temporally controlled translation of maternal transcripts, particularly in the coordination of meiotic and early embryonic development when transcription has ceased.
L. Lamačová +9 more
semanticscholar +1 more source
Hepatita cronica delta: de la descoperire la tratamente noi [PDF]
, 2021 Nicolae TestemitanuState University of Medicine and Pharmacy of the Republic of MoldovaIntroduction. Hepatitis delta virus (HDV) is a small, defective RNA virus that is related more to plant viroids than to other human pathogens.
Turcanu, Adela, Wani, Suhaib Tahir
core
Diversity and evolution of viroids and viroid-like RNA agents [PDF]
Viroids are the smallest and simplest known pathogens. Comprised of circular noncoding RNA, these agents can cause fatal diseases in plants. Although other viroid-like agents such as satellite RNAs, ribozyviruses, and retrozymes have been discovered, the
Lee, Benjamin
core +2 more sources
Anticodon-like loop-mediated dimerization in the crystal structures of HDV-like CPEB3 ribozymes
bioRxiv, 2023 Anna Ilaria Przytula-Mally +5 more
semanticscholar +1 more source
ACS Synthetic Biology, 2019 Synthetic riboswitches based on small molecule-responsive self-cleaving ribozymes (aptazymes) embedded in the untranslated regions (UTRs) allow chemical control of gene expression in mammalian cells. In this work, we used a guanine-responsive aptazyme to
Kei Takahashi, Y. Yokobayashi
semanticscholar +1 more source
Ribozymes of the RNA World: Investigating Ancient Enzymes through Modern Self-Cleaving Ribozymes. [PDF]
, 2016 Ribozymes are RNAs that can perform catalytic functions. The discovery of ribozymes was an important milestone in science because it not only opened new avenues of research but also provided insights into the origins of life on Earth.
Mir, Aamir
core +1 more source
Advancement of scienceThe regulation of gene expression by light enables the versatile, spatiotemporal manipulation of biological function in bacterial and mammalian cells.
Georg Pietruschka +9 more
semanticscholar +1 more source