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Paget’s disease of bone is the most common metabolic bone disease after osteoporosis and affects 2-4% of adults over 55 years of age. Its etiology is only partly understood and includes both genetic and environmental factors.
Bertoldi, I. +11 more
core +1 more source
A Case of Paget’s Disease with Scapula Involvement [PDF]
Paget’s disease is a common bone disorder which is characterized by excessive bone turnover. This condition rarely involves sternum, patella, scapula, hand, foot and facial bones. A 65-year-old male patient was admitted to our outpatient clinic with the
Duygu Geler Külcü +3 more
core +1 more source
Murine amniotic fluid stem cells contribute mesenchymal but not epithelial components to reconstituted mammary ducts [PDF]
Introduction: Amniotic fluid harbors cells indicative of all three germ layers, and pluripotent fetal amniotic fluid stem cells (AFSs) are considered potentially valuable for applications in cellular therapy and tissue engineering.
Bernd Groner +5 more
core +1 more source
In the original study by Rakha et al., the authors proposed that high‐grade EPC should be considered within an invasive framework regardless of hormone receptor status. In the present study, we adopted a more selective definition of EPC‐A, restricted to tumours showing more adverse features, including high‐grade morphology together with triple‐negative
Milena Stevanovic +9 more
wiley +1 more source
Differentiating Inflammatory Breast Cancer From Lactational Mastitis: A Diagnostic Challenge
Abstract Inflammatory breast cancer (IBC) is a rare but aggressive form of cancer; hence, early diagnosis is essential. Although predominantly occurring in older women, it can occur during pregnancy and lactation, making the diagnosis especially challenging.
Irena Zakarija‐Grković
wiley +1 more source
Cancer Cell Metastasis: From Molecular Mechanisms to Therapeutic Strategies
The schematic representation of intrinsic and extrinsic influences of cancer cell metastasis. Genomic evolution of metastatic tumor cells (MTCs) promotes their metastatic phenotypes and reconstruct the primary tumor microenvironment. During MTCs migration along different routes (blood circulation, lymphatic vessels, and perineuronal spaces), the ...
Yupeng Zhao +7 more
wiley +1 more source
ß1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli [PDF]
Integrins are cell adhesion receptors which mediate interactions between the extracellular matrix and the actin cytoskeleton. They are heterodimers composed of α and β subunits. As adhesion receptors, integrins are important for cell-cell and cell-matrix
Li, Na
core +1 more source
Role of Extracellular Vesicles in Shaping Immune Responses in the Lymph Node Microenvironment
Functional alliances of stromal, innate and adaptive immune cells in EV immunity in the lymph node. EV reflect the phenotype of their mother cell and cluster material from their surroundings. In the lymph node, EV preserve valuable context information between multiple cellular effectors to coordinate immunity in adaption to change.
Alicia Charrier +4 more
wiley +1 more source
Fragmented skeletonised remains: Paget’s disease as a method of biological profiling using radiography [PDF]
Background: This study presents the incidental finding of Paget’s disease within archaeological skeletal remains using radiography. The remains of a late medieval (14th-15th century AD) adult male were excavated in 2017 from St Albans Monks’ Graveyard ...
Teoaca, A. +4 more
core +1 more source
Mamary Paget's disease presents with subtle and insidious symptoms leading to late diagnosis that poses medical challenges. This uncommon pathology often has underlying ductal breast cancer, including in situ or invasive breast cancer, which makes early ...
Sawitri Darmiati, MD +2 more
doaj +1 more source

