Results 91 to 100 of about 1,583,153 (391)

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Adoption of practice guidelines and assessment tools in substance abuse treatment

Substance Abuse Treatment, Prevention, and Policy, 2010
Background The gap between research and practice limits utilization of relevant, progressive and empirically validated strategies in substance abuse treatment.
McCarty Dennis, Saedi Goal, Fuller Bret E, Rieckmann Traci   +3 more
doaj   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Harm reduction services as a point-of-entry to and source of end-of-life care and support for homeless and marginally housed persons who use alcohol and/or illicit drugs: a qualitative analysis

BMC Public Health, 2012
Background Homeless and marginally housed persons who use alcohol and/or illicit drugs often have end-of-life care needs that go unmet due to barriers that they face to accessing end-of-life care services.
McNeil Ryan, Guirguis-Younger Manal, Dilley Laura B, Aubry Tim D, Turnbull Jeffrey, Hwang Stephen W   +5 more
doaj   +1 more source

Paying for Quality: Understanding and Assessing Physician Pay-for-Performance Initiatives [PDF]

, 2007
Reviews the structure, prevalence, measurement issues, perception, and impact of current quality incentive programs, and discusses how much and under what circumstances they will improve quality of care.
Jon B. Christianson, Kim Sutherland, Sheila Leatherman   +2 more
core  

Overregulation of Health Care: Musings on Disruptive Innovation Theory [PDF]

, 2006
Disruptive innovation theory provides one lens through which to describe how regulations may stifle innovation and increase costs. Basing their discussion on this theory, Curtis and Schulman consider some of the effects that regulatory controls may have ...
Dahlqvist Leinhard, Olof, Leijon, Göran, Lundberg, Peter, Lundin, Fredrik, Tisell, Anders, Tullberg, M., Wikkelso, C.   +6 more
core   +5 more sources

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Effects of the Nurse-led Program on Disability Improvement in Patients with Stroke: A Systematic Review and Meta-analysis

Journal of Disability Research
Stroke holds the third position globally as a cause of combined morbidity and mortality, presenting a dire prognosis. This study aims to investigate the hypothesis that nurse-led rehabilitation and follow-up programs offer a significant improvement in ...
Khalid Abduallah Aljohani, Hammad Ali Fadlalmola, Doaa El Sayed Fadila   +2 more
doaj   +1 more source

Children's Health Coverage Facts and Figures [PDF]

, 2009
Outlines trends in children's health insurance in California. Reviews 1997-2009 milestones in expanding coverage and examines uninsurance rates; eligibility for and enrollment in public programs; sources of coverage by income and age; and access to ...
Dana Hughes, Michael R. Cousineau
core