Results 141 to 150 of about 20,758,202 (342)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Fuzzy Optimal Energy Management for Fuel Cell and Supercapacitor Systems Using Neural Network Based Driving Pattern Recognition

, 2018
Ridong Zhang, Jili Tao, Huiyu Zhou
openalex   +2 more sources

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Water governance in the Mekong region: the need for more informed policy-making [PDF]

Water management / River basins / Governance / Policy making / Planning / Water law / South East Asia / China / Vietnam / Cambodia ...
International Water Management Institute (IWMI).
core  

Critical success factors for implementation of supply chain management in Indian small and medium enterprises and their impact on performance

, 2015
Ravinder Kumar, Raj Singh, Ravi Shankar
openalex   +1 more source

Biodiversity data synthesis on trees of Indian Himalayan Region: Policy and management implications

, 2023
Sajad Ahmad Wani, Muzamil Ahmad Mugal, Firdous Ahmad Dar, C. Sudhakar Reddy, Irfan Rashid, Anzar Ahmad Khuroo   +5 more
openalex   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Rapid desktop assessments of environmental flows [PDF]

Environmental flows / Calculators / Computer techniques / Rivers ...
International Water Management Institute (IWMI).
core  

Preemptive effects of etoricoxib, acetaminophen, nimesulide, and ibuprofen on postoperative pain management after single‐implant surgery: A randomized clinical trial [PDF]

, 2023
Gustavo Henrique Mattos Pereira, Rafael Paschoal Esteves Lima, Luís Otávio Miranda Cota, Rachel Alvarenga‐Brant, Fernando Oliveira Costa   +4 more
openalex   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source