Results 81 to 90 of about 18,378,984 (312)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
EurosurveillanceAn outbreak of severe acute hepatitis of unknown aetiology in children (HUAC) was reported by the United Kingdom (UK) in spring 2022. Within days, a corresponding increase was identified in Ireland.
on behalf of the Incident Management Team
doaj +1 more source
Work-Life Balance and Job Performance: A Mediating and Moderating Model
Market Forces, 2022 Work-life balance has become a critical issue in the service sector, especially in the banks. Given its importance, we have developed a model with four direct and two indirect hypotheses. We developed a questionnaire based on the past studies, containing
Asima Faisal +2 more
doaj
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
EurosurveillanceWe managed a complex outbreak of Shiga toxin-producing Escherichia coli (STEC) and stx-negative E. coli O157 (non-STEC) cases in four nurseries in two neighbouring towns in south-east Scotland, with epidemiological links through shared management, staff ...
on behalf of the Incident Management Team
doaj +1 more source
Irrigation management transfer: how to make it work for Africa’s smallholders? [PDF]
Water management / Privatization / Small scale systems / Small holders ...
International Water Management Institute (IWMI).
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Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Reducing soil degradation to increase resilience to climate change and strengthen livelihoods in Ethiopia. [PDF]
, 2019 Soil degradation is a major problem in Ethiopia. Depletion of soil organic matter is a cause of low agricultural productivity, as soils become less fertile and less resilient to extreme weather events, which are expected to increase with climate change ...
International Water Management Institute
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