Results 121 to 130 of about 4,071,858 (310)

National stroke management plan in Uruguay: Challenges and opportunities. [PDF]

Front Neurol, 2022
Amorín I, Savia A, Gaye A, Camejo C, Triviño B, Muñoz M, Yancev S, Menendez T, Decima R.   +8 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Retracted: The Value of a Management Plan Based on Risk Factors for Cerebral Infarction Patients with Cerebral Hemorrhage. [PDF]

J Healthc Eng, 2023
Healthcare Engineering JO.
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Management plan for teachers at the Táchira Sports Talent School to promote and incorporate ICT tools into the teaching and learning process

Mundo Fesc
The study aimed to design an Information and Communication Technologies (ICT) management plan for the Táchira Sports Talent School (ETDT) to strengthen institutional management and optimize pedagogical and administrative processes.
Janeth Coromoto Ramírez Andrade, Gerardo José Sánchez Esteves, José Vicente Sánchez Frank   +2 more
doaj   +1 more source

Coastal management in Brazil from the perspective of the public policy cycle: Analysis of the "multiscale management" proposed in the National Coastal Management Plan. [PDF]

Camb Prism Coast Futur, 2023
Pinheiro GDS, Tupiassu L, Reymão AEN.
europepmc   +1 more source

Formulation of consumables management models: Test plan for the mission planning processor working model [PDF]

The test plan and test procedures to be used in the verification and validation of the software being implemented in the mission planning processor working model program are documented.
Connelly, L. C.
core   +1 more source

Resource management, plan quality and governance: A report to Government [PDF]

, 2001
This Report contains the main findings from FRST-funded research into planning under the Resource Management Act. It includes five sets of interrelated recommendations.
Berke, Philip, Crawford, Janet, Dixon, Jennifer, Ericksen, Neil   +3 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source